Gramicidin D is a short peptide which dimerizes to form helical pores, adopting one of two conformations in the process. These conformations… Continue reading Distinguishing gramicidin D conformers through two-dimensional infrared spectroscopy of vibrational excitons
Leah Pandiscia, PhD
July 28, 2017
Forkhead box P2 (FOXP2) is a transcription factor expressed in cardiovascular, intestinal, and neural tissues during embryonic development and is… Continue reading The effect of pH on the structure and DNA binding of the FOXP2 forkhead domain
Leah Pandiscia, PhD
July 28, 2017
Antibiotic resistance has become a major health problem. The σ70:core interface of bacterial RNA polymerase is a promising drug target.… Continue reading Surface plasmon resonance – more than a screening technology: insights in the binding mode of σ70:core RNAP inhibitors
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
We report optically active ensembles of II-VI semiconductor nanocrystals prepared via chiral phase transfer, which is initiated by exchange of… Continue reading Optically active II-VI semiconductor nanocrystals via chiral phase transfer
Leah Pandiscia, PhD
May 24, 2018
The role of Ca2+ in gelation of myosin extracted from silver carp (Hypophthalmichthys molitrix) was investigated. Compared with the control, myosin… Continue reading Ca2+ -Induced Conformational Changes of Myosin from Silver Carp (Hypophthalmichthys molitrix ) in Gelation
Leah Pandiscia, PhD
July 28, 2017
A series of chiral aryl amide compounds bearing peptide pendants have been investigated as low molecular weight gelators. A mechanistic… Continue reading Multi-stimuli-responsive chiral organogels based on peptide derivatives
Leah Pandiscia, PhD
July 28, 2017
The human (h) ZIP4 transporter is a plasma membrane protein which functions to increase the cytosolic concentration of zinc. hZIP4… Continue reading The large intracellular loop of hZIP4 is an intrinsically disordered zinc binding domain
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Folic acid has emerged as an interesting cell-targeting moiety and a number of drugs have been conjugated to folate. In… Continue reading Folate–Cyclodextrin Conjugates as Carriers of the Platinum(IV) Complex LA-12
Leah Pandiscia, PhD
July 28, 2017
A large variety of cross-linked cyclodextrin polymers exhibiting interesting properties towards various guests have been characterized. Some polymeric nanoparticles based… Continue reading Novel amino-cyclodextrin cross-linked oligomer as efficient carrier for anionic drugs: a spectroscopic and nanocalorimetric investigation
Leah Pandiscia, PhD
July 28, 2017
Novozyme435, which is a successfully commercialized biocatalyst, can efficiently catalyze the ring-opening polymerization (ROP) of lactones. However, for six-membered unsubstituted… Continue reading Coating Novozyme435 with an ionic liquid: more than just a coating for the efficient ring-opening polymerization of δ-valerolactone
Leah Pandiscia, PhD
July 28, 2017
Active surface of luminescent silicon nanoparticles was terminated by the photochemical reaction of chiral molecules, (S)- or (R)-5-allyl-2-oxabicyclo[3,3,0]oct-8-ene ((S) –… Continue reading Luminescent Silicon Nanoparticles Surface-Modified with Chiral Molecules
Leah Pandiscia, PhD
May 24, 2018
The structure and stability of biomolecules under molecular crowding conditions are of interest because such information clarifies how biomolecules behave… Continue reading Stabilization of DNA Structures with Poly(ethylene sodium phosphate)
Leah Pandiscia, PhD
July 28, 2017
A new family of nickel–lanthanide heterometallic dinuclear complexes derived from a chiral Schiff-base ligand, (R,R)-N,N′-bis(3-methoxysalicylidene)cyclohexane-1,2-diamine (H2L), namely [Ni(L)Ln(NO3)3(H2O)] (Ln = Ce (1),… Continue reading A family of nickel–lanthanide heterometallic dinuclear complexes derived from a chiral Schiff-base ligand exhibiting single-molecule magnet behaviors
Leah Pandiscia, PhD
July 28, 2017
The N-terminal amino acid 1–83 fragment of apolipoprotein A-I (apoA-I) has a strong propensity to form amyloid fibrils at physiological… Continue reading Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
To support drug discovery efforts for cyclin-dependent kinase 2 (CDK2), a moderate-throughput binding assay that can rank order or estimate… Continue reading Ligand binding affinity determined by temperature-dependent circular dichroism: Cyclin-dependent kinase 2 inhibitors
Leah Pandiscia, PhD
July 28, 2017
Immobilised enzymes are widely used in industry, but the reasons for loss of activity of such biocatalysts are usually not… Continue reading Circular dichroism studies of subtilisin Carlsberg immobilised on micron sized silica particles
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017