Found 9617 Results / Page 477 of 481
2016 / Journal of Natural Products
Two new diterpenoid α-pyrones, named higginsianins A (1) and B (2), were isolated from the mycelium of the fungus Colletotrichum higginsianum grown… Continue reading Higginsianins A and B, Two Diterpenoid α‑Pyrones Produced by Colletotrichum higginsianum, with in Vitro Cytostatic Activity
2016 / Journal of Chemical Information and Modeling
Structurally conserved water molecules are important for biomolecular stability, flexibility, and function. X-ray crystallographic studies of Pin1 have resolved a… Continue reading Conserved Hydration Sites in Pin1 Reveal a Distinctive Water Recognition Motif in Proteins
2016 / Journal of Natural Products
Twelve new dimeric sesquiterpenoids (1–12) were isolated from the dried whole plants ofArtemisia rupestris. Their structures were determined using MS… Continue reading Nitric Oxide Inhibitory Dimeric Sesquiterpenoids from Artemisia rupestris
2016 / Journal of Natural Products
Purification of a diethyl ether extract of the Argentinian fern Elaphoglossum lindbergii afforded five new prenylated acylphloroglucinols, lindbergins E–I (1–5), of which… Continue reading Prenylated Acylphloroglucinols with Leishmanicidal Activity from the Fern Elaphoglossum lindbergii
2016 / Journal of Natural Products
Theacitrins A–C are yellow pigments of black tea that are produced by oxidative coupling of gallocatechins, i.e., flavan-3-ols with pyrogallol-type… Continue reading Stereochemistry of the Black Tea Pigments Theacitrins A and C
2015 / Chemical Research in Toxicology
The redox state of disulfide bonds is implicated in many redox control systems, such as the cysteine–cystine couple. Among proteins,… Continue reading Redox Reactivity of Cerium Oxide Nanoparticles Induces the Formation of Disulfide Bridges in Thiol-Containing Biomolecules
2015 / Inorganic Chemistry
Metalation of 6,13,20,21-tetrakis-aryl-22H-[14]tribenzotriphyrin(2.1.1) (TriPs) with PdCl2provides PdII–TriP complexes in 45–56% yields. The complexes were characterized by mass spectrometry, and UV–visible… Continue reading Synthesis and Characterization of Palladium(II) Complexes of meso-Substituted [14]Tribenzotriphyrin(2.1.1)
2015 / Inorganic Chemistry
Silver(I) is an unphysiological ion that, as the physiological copper(I) ion, shows high binding affinity for thiolate ligands; its toxicity… Continue reading XAS Investigation of Silver(I) Coordination in Copper(I) Biological Binding Sites
2015 / Journal of Physical Chemistry B
Insulin aggregation, to afford amyloidogenic polypeptide fibrils, is an energetically driven, well-studied phenomenon, which presents interesting biological ramifications. These aggregates… Continue reading Controlling in Vitro Insulin Amyloidosis with Stable Peptide Conjugates: A Combined Experimental and Computational Study
2015 / ACS Chemical Neuroscience
A variety of species express the amyloid β-protein (Aβ (the term “Aβ” refers both to Aβ40 and Aβ42, whereas “Aβ40”… Continue reading Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity
2015 / Biochemistry
Dimethyl sulfoxide (DMSO) induced destabilization of insulin fibrils has been previously studied by Fourier transform infrared spectroscopy and interpreted in… Continue reading Dimethyl Sulfoxide Induced Destabilization and Disassembly of Various Structural Variants of Insulin Fibrils Monitored by Vibrational Circular Dichroism
2015 / ACS Biomaterials Science and Engineering
Secreted frizzled-related protein 1 (SFRP1) is a natural blocker of the Wnt signaling pathway in normal adult cells but is… Continue reading Targeting Wnt Canonical Signaling by Recombinant sFRP1 Bound Luminescent Au-Nanocluster Embedded Nanoparticles in Cancer Theranostics
2016 / ACS Chemical Biology
Tristetraprolin (TTP) binds to mRNA transcripts to promote their degradation. The TTP protein family in humans includes two other proteins,… Continue reading Three Residues Make an Evolutionary Switch for Folding and RNA-Destabilizing Activity in the TTP Family of Proteins
2015 / Biomacromolecules
In this work we quantified the role of electrostatic interactions in the self-assembly of a model amphiphilic peptide (RADA 16-I)… Continue reading Contribution of Electrostatics in the Fibril Stability of a Model Ionic-Complementary Peptide
2015 / Biomacromolecules
The effectiveness of a drug may be highly dependent on its delivery to its target organ and even to specific… Continue reading Coassemblies of the Anionic Polypeptide γ‑PGA and Cationic β‑Sheet Peptides for Drug Delivery to Mitochondria
2016 / Crystal Growth and Design
Extrapallial fluid (EPF) is located between the shell and the mantle, and it is believed to play key roles in… Continue reading Influence of the Extrapallial Fluid of Pinctada fucata on the Crystallization of Calcium Carbonate and Shell Biomineralization
2016 / ACS Applied Materials and Interfaces
Nanomaterials hold potential of altering the interaction between therapeutic molecules and target cells or tissues. High aspect ratio nanomaterials in… Continue reading Spontaneous Protein Adsorption on Graphene Oxide Nanosheets Allowing Efficient Intracellular Vaccine Protein Delivery
2016 / Analytical Chemistry
To obtain insight into pH change-driven molecular dynamics, we studied the higher order structure changes of protein G′e at the molecular… Continue reading A Dynamic Model of pH-Induced Protein G′e Higher Order Structure Changes derived from Mass Spectrometric Analyses
2016 / Chemical Research in Toxicology
Frameshift mutagenesis encompasses the gain or loss of DNA base pairs, resulting in altered genetic outcomes. The NarI restriction site sequence… Continue reading Conformational Insights into the Mechanism of Acetylaminofluorene-dG-Induced Frameshift Mutations in the NarI Mutational Hotspot
2016 / Inorganic Chemistry
Three chiral ligands with variable denticity, H2L2–H2L4, conjugated by N,N′-ethylenebis[N-methyl-(S)-alanine] and an ortho-heterosubstituted aromatic amine, were newly synthesized as analogues of… Continue reading Redox-Triggered Helicity Inversion in Chiral Cobalt Complexes in Combination with H+ and NO3 − Stimuli
