2022 / The Journal of Physical Chemistry Letters, J. Phys. Chem. Lett. 2022, 13, 34, 8010–8018
RNA plays a critical role in many biological processes, and the structures it adopts are intimately linked to those functions.… Continue reading Base-Stacking Heterogeneity in RNA Resolved by Fluorescence-Detected Circular Dichroism Spectroscopy
2023 / Scientific Reports
LI-cadherin is a member of the cadherin superfamily. LI-cadherin mediates Ca2+-dependent cell–cell adhesion through homodimerization. A previous study reported two… Continue reading Molecular Mechanism Underlying the Increased Risk of Colorectal Cancer Metastasis Caused by Single Nucleotide Polymorphisms in LI-Cadherin Gene
2023 / Scientific Reports
The kinase-inducible domain interacting (KIX) domain is an integral part of the general transcriptional coactivator CREB-binding protein, and has been… Continue reading Rational Peptide Design for Inhibition of the KIX–MLL Interaction
2023 / Nature Communications
African Trypanosomes have developed elaborate mechanisms to escape the adaptive immune response, but little is known about complement evasion particularly… Continue reading Cryo-EM Structures of Trypanosoma Brucei Gambiense ISG65 with Human Complement C3 and C3b and Their Roles in Alternative Pathway Restriction
2023 / Food Frontiers
In this study, complexes formed by sodium caseinate (CS) and different concentrations of (−)-epigallocatechin-3-gallate (EGCG) were successfully prepared. The structures… Continue reading Chemical and Thermodynamic Characterization of Antioxidant Emulsifiers: The Case of Complex of Sodium Caseinate with EGCG
2023 / Nature Communications
Multi-enzymatic cascades with enzymes arranged in close-proximity through a protein scaffold can trigger a substrate channeling effect, allowing for efficient… Continue reading Engineered Repeat Proteins as Scaffolds to Assemble Multi-Enzyme Systems for Efficient Cell-Free Biosynthesis
2023 / Scientific Reports
Liquid–liquid phase separation is a phenomenon that features the formation of liquid droplets containing concentrated solutes. The droplets of neurodegeneration-associated… Continue reading Label-Free Autofluorescence Lifetime Reveals the Structural Dynamics of Ataxin-3 inside Droplets Formed via Liquid–Liquid Phase Separation
2023 / Molecular Microbiology
Bacterial signal transduction systems are typically activated by the binding of signal molecules to receptor ligand binding domains (LBDs), such… Continue reading Study of NIT Domain-Containing Chemoreceptors from Two Global Phytopathogens and Identification of NIT Domains in Eukaryotes
2023 / Chemistry – A European Journal
Stapled peptides are a unique class of cyclic α-helical peptides that are conformationally constrained via their amino acid side-chains. They… Continue reading Development of Bifunctional, Raman Active Diyne-Girder Stapled α-Helical Peptides
2023 / Nature Communications
The 2,5-diketopiperazines are a prominent class of bioactive molecules. The nocardioazines are actinomycete natural products that feature a pyrroloindoline diketopiperazine… Continue reading Unveiling an Indole Alkaloid Diketopiperazine Biosynthetic Pathway That Features a Unique Stereoisomerase and Multifunctional Methyltransferase
2023 / Scientific Reports
Self-assembling peptides can be used for the regeneration of severely damaged skin. They can act as scaffolds for skin cells… Continue reading Release Systems Based on Self-Assembling RADA16-I Hydrogels with a Signal Sequence Which Improves Wound Healing Processes
2023 / Scientific Reports
A novel hybrid protein composed of a superoxide dismutase-active Cu(II) complex (CuST) and lysozyme (CuST@lysozyme) was prepared. The results of… Continue reading A Novel Hybrid Protein Composed of Superoxide-Dismutase-Active Cu(II) Complex and Lysozyme
2023 / ChemCatChem
Indole is a significant structural moiety and functionalization of the C?H bond in indole-containing molecules expands their chemical space, and… Continue reading Structure-Guided Mutagenesis Reveals the Catalytic Residue That Controls the Regiospecificity of C6-Indole Prenyltransferases
2023 / Nature Communications
Designing metal sites into de novo proteins has significantly improved, recently. However, identifying the minimal coordination spheres, able to encompass… Continue reading Designed Rubredoxin Miniature in a Fully Artificial Electron Chain Triggered by Visible Light
2023 / Advanced Materials Interfaces
Solid interfacing biomaterials is a crucial aspect of bionanotechnology and important for applications such as biosensing. Because of their potentially… Continue reading Flat Solenoidal Ice-Binding Proteins as Scaffolds for Solid-Binders
2023 / Nature Ecology & Evolution
Highly specific interactions between proteins are a fundamental prerequisite for life, but how they evolve remains an unsolved problem. In… Continue reading Fortuitously Compatible Protein Surfaces Primed Allosteric Control in Cyanobacterial Photoprotection
2023 / Communications Biology
The angiotensin-converting enzyme 2 (ACE2) is a viral receptor used by sarbecoviruses to infect cells. Fusion proteins comprising extracellular ACE2… Continue reading Extrinsic Stabilization of Antiviral ACE2-Fc Fusion Proteins Targeting SARS-CoV-2
2023 / Nature
General approaches for designing sequence-specific peptide-binding proteins would have wide utility in proteomics and synthetic biology. However, designing peptide-binding proteins… Continue reading De Novo Design of Modular Peptide-Binding Proteins by Superhelical Matching
2023 / Advanced NanoBiomed Research
Antibiotics are losing effectiveness as bacteria become resistant to conventional drugs. To find new alternatives, antimicrobial peptides (AMPs) are rationally… Continue reading Novel Helical Trp- and Arg-Rich Antimicrobial Peptides Locate Near Membrane Surfaces and Rigidify Lipid Model Membranes
2023 / Advanced Materials Interfaces
Ice formation on a solid surface is a major challenge in industrial applications, it causes higher energy consumption and performance… Continue reading Development and Implementation of Microbial Antifreeze Protein Based Coating for Anti-Icing
