2022 / Nature Communications
Precise control of morphology and optical response of 3-dimensional chiral nanoparticles remain as a significant challenge. This work demonstrates chiral… Continue reading Adenine oligomer directed synthesis of chiral gold nanoparticles
2022 / Scientific Reports
The emergence of multidrug resistance coupled with shrinking antibiotic pipelines has increased the demand of antimicrobials with novel mechanisms of… Continue reading Design, characterization and structure–function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment
2022 / Scientific Reports
Copper-zinc superoxide dismutase (SOD1) has been proposed as one of the causative proteins of amyotrophic lateral sclerosis (ALS). The accumulation… Continue reading SOD1 gains pro-oxidant activity upon aberrant oligomerization: change in enzymatic activity by intramolecular disulfide bond cleavage
2022 / Advanced Optical Materials
Chirality is a desired property in functional semiconductors for optoelectronic, catalytic, and spintronic applications. Here, introducing enantiomerically-pure 3-aminobutyric acid (3-ABA)… Continue reading Strong Induced Circular Dichroism in a Hybrid Lead-Halide Semiconductor Using Chiral Amino Acids for Crystallite Surface Functionalization
2022 / Nano Micro small
Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein… Continue reading Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination
2022 / Protein Science
Parkinson’s disease (PD) is a chronic multifactorial disease, whose etiology is not completely understood. The amyloid aggregation of α-synuclein (Syn)… Continue reading 3,4-Dihydroxyphenylethanol and 3,4-dihydroxyphenylacetic acid affect the aggregation process of E46K variant of α-synuclein at different extent: Insights into the interplay between protein dynamics and catechol effect
2022 / Protein Science
Homomers are prevalent in bacterial proteomes, particularly among core metabolic enzymes. Homomerization is often key to function and regulation, and… Continue reading Evolution of homo-oligomerization of methionine S-adenosyltransferases is replete with structure–function constrains
2022 / Nature Communications
In the literature, organic materials with both aggregation-induced emission (AIE) and aggregation-caused quenching (ACQ) effects that can emit with multiple… Continue reading An unexpected dual-emissive luminogen with tunable aggregation-induced emission and enhanced chiroptical property
2022 / Scientific Reports
We report a method for the simultaneous determination of the sequence and absolute configuration of peptide amino acids using a… Continue reading Determination of sequence and absolute configuration of peptide amino acids by HPLC–MS/CD-based detection of liberated N-terminus phenylthiohydantoin amino acids
2022 / Nature Communications
The cytochrome P450 family of enzymes (CYPs) are important targets for medicinal chemistry. Recently, CYP1B1 has emerged as a key… Continue reading Ru(II) photocages enable precise control over enzyme activity with red light
2022 / Nature Communications
Sequential energy transfer is ubiquitous in natural light harvesting systems to make full use of solar energy. Although various artificial… Continue reading A bioinspired sequential energy transfer system constructed via supramolecular copolymerization
2022 / Nature Communications
Development of highly efficient and stable lateral organic circularly polarized light photodetector is a fundamental prerequisite for realization of circularly… Continue reading Organic donor-acceptor heterojunctions for high performance circularly polarized light detection
2022 / Scientific Reports
Chikungunya virus (CHIKV) is the causative agent of Chikungunya fever, an acute febrile and arthritogenic illness with no effective treatments… Continue reading Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate
2022 / Communication Chemistry
RAS oncoproteins are molecular switches associated with critical signaling pathways that regulate cell proliferation and differentiation. Mutations in the RAS… Continue reading Controlling oncogenic KRAS signaling pathways with a Palladium-responsive peptide
2022 / Scientific Reports
Numerous studies have shown that nanosized zeolitic imidazolate framework particles (ZIF-8 NPs) serve as promising vehicles for pH-responsive drug delivery.… Continue reading Mechanistic interaction studies of synthesized ZIF-8 nanoparticles with bovine serum albumin using spectroscopic and molecular docking approaches
2022 / Chirality
Protein-polymer conjugates are a blooming class of hybrid systems with high biomedical potential. Despite a plethora of papers on their… Continue reading A circular dichroism study of the protective role of polyphosphoesters polymer chains in polyphosphoester-myoglobin conjugates
2022 / ChemBioChem
Ribonuclease S (RNase S) is an enzyme that exhibits anticancer activity by degrading RNAs within cancer cells; however, the cellular… Continue reading Anticancer Activity of Reconstituted Ribonuclease S-Decorated Artificial Viral Capsid
2022 / Nature Communications
Hierarchically structured chiral luminescent materials hold promise for achieving efficient circularly polarized luminescence. However, a feasible chemical route to fabricate… Continue reading Biomimetic non-classical crystallization drives hierarchical structuring of efficient circularly polarized phosphors
2022 / Aggregate
Developing new templates to evaluate the ligand engineering effect in manipulating nanoclusters from both molecular and supramolecular aspects remains highly… Continue reading Secondary ligand engineering of nanoclusters: Effects on molecular structures, supramolecular aggregates, and optical properties
2022 / Biotechnology Journal
SARS-CoV-2 Spike is a key protein that mediates viral entry into cells and elicits antibody responses. Its importance in infection,… Continue reading Production of novel SARS-CoV-2 Spike truncations in Chinese hamster ovary cells leads to high expression and binding to antibodies
