2022 / Smart Mat
Highly efficient second-harmonic generation (SHG) has facilitated the development of nanophotonics and sustained promising applications, ranging from electro-optical modulation, frequency… Continue reading Reversible phase transition for switchable second harmonic generation in 2D perovskite microwires
2022 / Structural biology
The Kv family of voltage-gated potassium channels regulate neuronal excitability. The biophysical characteristics of Kv channels can be matched to… Continue reading Pentameric assembly of the Kv2.1 tetramerization domain
2022 / FASEB Journal
Structural discovery of guanine nucleotide exchange factor (GEF) protein complexes is likely to become increasingly relevant with the development of… Continue reading Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma
2022 / Nature Communications
The STORR gene fusion event is considered essential for the evolution of the promorphinan/morphinan subclass of benzylisoquinoline alkaloids (BIAs) in… Continue reading A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago
2022 / Nature Communications
Chiral perovskites are being extensively studied as a promising candidate for spintronic- and polarization-based optoelectronic devices due to their interesting… Continue reading Elucidating the origin of chiroptical activity in chiral 2D perovskites through nano-confined growth
2022 / Nature Communications
BRCA2-deficient cells precipitate telomere shortening upon collapse of stalled replication forks. Here, we report that the dynamic interaction between BRCA2… Continue reading Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis
2022 / Nature Communications
Polypropylene fibres are difficult to dye using commonly used techniques due to the high crystallinity and non-polar aliphatic structure, that… Continue reading pH- and concentration-dependent supramolecular assembly of a fungal defensin plectasin variant into helical non-amyloid fibrils
2022 / Nature Chemical Biology
Protein tertiary structure mimetics are valuable tools to target large protein–protein interaction interfaces. Here, we demonstrate a strategy for designing… Continue reading A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein
2022 / Scientific Reports
The streptavidin–biotin system is known to have a very high affinity and specificity and is widely used in biochemical immunoassays… Continue reading Mirror-image streptavidin with specific binding to L-biotin, the unnatural enantiomer
2022 / Nature Communications
Protein therapeutics frequently face major challenges, including complicated production, instability, poor solubility, and aggregation. De novo protein design can readily… Continue reading A topological refactoring design strategy yields highly stable granulopoietic proteins
2022 / Nature Communications
All living organisms have the ability to sense nutrient levels to coordinate cellular metabolism. Despite the importance of nutrient-sensing pathways… Continue reading O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine
2022 / Nature Communications
The RTX (repeats-in-toxin) domain of the bacterial toxin adenylate cyclase (CyaA) contains five RTX blocks (RTX-i to RTX-v) and its… Continue reading Templated folding of the RTX domain of the bacterial toxin adenylate cyclase revealed by single molecule force spectroscopy
2022 / Nature Communications
Intimately connected to the rule of life, chirality remains a long-time fascination in biology, chemistry, physics and materials science. Chiral… Continue reading Chiral emergence in multistep hierarchical assembly of achiral conjugated polymers
2022 / Scientific Reports
The protein HSF-1 is the controlling transcription factor of the heat-shock response (HSR). Its binding to the heat-shock elements (HSEs)… Continue reading Binding of the HSF-1 DNA-binding domain to multimeric C. elegans consensus HSEs is guided by cooperative interactions
2022 / Scientific Reports
Calcium (Ca2+) is well known as a second messenger in eukaryotes, where Ca2+ signaling controls life-sustaining cellular processes. Although bacteria… Continue reading EF-hand protein, EfhP, specifically binds Ca2+ and mediates Ca2+ regulation of virulence in a human pathogen Pseudomonas aeruginosa
2022 / PROTEIN SCIENCE
Evolution minimizes the number of highly conserved amino acid residues in proteins to ensure evolutionary robustness and adaptability. The roles… Continue reading The roles of highly conserved, non-catalytic residues in class A β-lactamases
2021 / Nucleic Acids Research ,Volume 49, Issue 14, 20 August 2021, Pages 7856–7869
The MYCN gene encodes the transcription factor N-Myc, a driver of neuroblastoma (NB). Targeting G-quadruplexes (G4s) with small molecules is… Continue reading Targeting a noncanonical, hairpin-containing G-quadruplex structure from the MYCN gene
2022 / Protein science
The conformational landscape of a protein is constantly expanded by genetic variations that have a minimal impact on the function(s)… Continue reading Structural dynamics shape the fitness window of alanine:glyoxylate aminotransferase
2022 / ADVANCED SCIENCE
The chiral-induced spin selectivity effect enables the application of chiral organic materials for spintronics and spin-dependent electrochemical applications. It is… Continue reading Hybrid Chiral MoS2 Layers for Spin-Polarized Charge Transport and Spin-Dependent Electrocatalytic Applications
2022 / Engineering
Prokaryotic expression systems are widely used to produce many types of biologics because of their extreme conveniences and unmatchable cost.… Continue reading Conversion of recombinant human ferritin light chain inclusion bodies into uniform nanoparticles in Escherichia coli for facile production
