We report the facile synthesis of TbIII and EuIII adducts able to elicit circularly polarized luminescence. Both the sensitization of… Continue reading Untitled
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2021 / CHemPhotoChem
Binding and/or hydrolysis of purine-based nucleotides is not required for IM30 ring formation
2021 / FEBS Letters
IM30, the inner membrane-associated protein of 30 kDa, is conserved in cyanobacteria and chloroplasts. Although its exact physiological function is… Continue reading Binding and/or hydrolysis of purine-based nucleotides is not required for IM30 ring formation
Resurrection and characterization of ancestral CYP11A1 enzymes
2021 / FEBS Journal
Mitochondrial cytochromes P450 presumably originated from a common microsomal P450 ancestor. However, it is still unknown how ancient mitochondrial P450s… Continue reading Resurrection and characterization of ancestral CYP11A1 enzymes
The Role of Peripheral Amide Groups as Hydrogen-Bonding Directors in the Tubular Self-Assembly of Dinucleobase Monomers
2021 / ChemPlusChem
Nanotubes are a fascinating kind of self-assembled structure which have a wide interest and potential in supramolecular chemistry. We demonstrated… Continue reading The Role of Peripheral Amide Groups as Hydrogen-Bonding Directors in the Tubular Self-Assembly of Dinucleobase Monomers
Characterization of recombinant β subunit of human MUC4 mucin (rMUC4β)
2021 / Scientific Reports
MUC4 is a transmembrane mucin expressed on various epithelial surfaces, including respiratory and gastrointestinal tracts, and helps in their lubrication… Continue reading Characterization of recombinant β subunit of human MUC4 mucin (rMUC4β)
Toxicity of internalized polyalanine to cells depends on aggregation
2021 / Scientific Reports
In polyalanine (PA) diseases, the disease-causing transcription factors contain an expansion of alanine repeats. While aggregated proteins that are responsible… Continue reading Toxicity of internalized polyalanine to cells depends on aggregation
Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12
2021 / Communications Biology
The synaptonemal complex (SC) is a supramolecular protein scaffold that mediates chromosome synapsis and facilitates crossing over during meiosis. In… Continue reading Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12
Peptides derived from gp43, the most antigenic protein from Paracoccidioides brasiliensis, form amyloid fibrils in vitro: implications for vaccine development
2021 / Scientific Reports
Fungal infection is an important health problem in Latin America, and in Brazil in particular. Paracoccidioides (mainly P. brasiliensis and… Continue reading Peptides derived from gp43, the most antigenic protein from Paracoccidioides brasiliensis, form amyloid fibrils in vitro: implications for vaccine development
Influence of the chirality of carbon nanodots on their interaction with proteins and cells
2021 / Nature Communications
Carbon nanodots with opposite chirality possess the same major physicochemical properties such as optical features, hydrodynamic diameter, and colloidal stability.… Continue reading Influence of the chirality of carbon nanodots on their interaction with proteins and cells
Circularly Polarized Luminescence of Some [2]Paracyclo[2](5,8)quinoliphane Derivatives with Planar and Central Chirality
2021 / CHemPhotoChem
With the aim of finding and characterizing new simple organic molecules (SOM) generating circularly polarized luminescence (CPL), we test here… Continue reading Circularly Polarized Luminescence of Some [2]Paracyclo[2](5,8)quinoliphane Derivatives with Planar and Central Chirality
Syntheses of Optically Active V-Shaped Molecules: Relationship Between their Chiroptical Properties and the Orientation of the Stacked π-Electron System
2021 / EurJOC
Two kinds of optically active V-shaped molecules were synthesized from enantiopure disubstituted and tetrasubstituted [2.2]paracyclophane as chiral building blocks. The… Continue reading Syntheses of Optically Active V-Shaped Molecules: Relationship Between their Chiroptical Properties and the Orientation of the Stacked π-Electron System
Mixed Multimetallic tris(2-pyridylmethyl)amine Based Complexes: Synthesis and Chiroptical Properties
2021 / EurJOC
Continuous intensification of reaction screening methodologies has required the development of novel high-throughput analytical technologies. This urge involves also chirality… Continue reading Mixed Multimetallic tris(2-pyridylmethyl)amine Based Complexes: Synthesis and Chiroptical Properties
Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity
2021 / ChemBioChem
Antibiotic resistance is a significant threat to human health, with natural products remaining the best source for new antimicrobial compounds.… Continue reading Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity
Giant single-crystal-to-single-crystal transformations associated with chiral interconversion induced by elimination of chelating ligands
2021 / Nature Communications
Numerous single crystals that exhibit single-crystal-to-single-crystal (SCSC) transformations have been reported, and some of them show great promise for application… Continue reading Giant single-crystal-to-single-crystal transformations associated with chiral interconversion induced by elimination of chelating ligands
N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization
2021 / Nature Communications
Synthesis of iron-sulfur (Fe/S) clusters in living cells requires scaffold proteins for both facile synthesis and subsequent transfer of clusters… Continue reading N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization
Plant LHC-like proteins show robust folding and static non-photochemical quenching
2021 / Nature Communications
Life on Earth depends on photosynthesis, the conversion of light energy into chemical energy. Plants collect photons by light harvesting… Continue reading Plant LHC-like proteins show robust folding and static non-photochemical quenching
Characterization of a G-quadruplex from hepatitis B virus and its stabilization by binding TMPyP4, BRACO19 and PhenDC3
2021 / Scientific Reports
Specific guanine rich nucleic acid sequences can form non-canonical structures, like the four stranded G-quadruplex (GQ). We studied the GQ-forming… Continue reading Characterization of a G-quadruplex from hepatitis B virus and its stabilization by binding TMPyP4, BRACO19 and PhenDC3
The effects of molecular crowding and CpG hypermethylation on DNA G-quadruplexes formed by the C9orf72 nucleotide repeat expansion
2021 / Scientific Reports
A nucleotide repeat expansion (NRE), (G4C2)n, located in a classically noncoding region of C9orf72 (C9), is the most common genetic… Continue reading The effects of molecular crowding and CpG hypermethylation on DNA G-quadruplexes formed by the C9orf72 nucleotide repeat expansion
Piperine analogs arrest c-myc gene leading to downregulation of transcription for targeting cancer
2021 / Scientific Reports
G-quadruplex (G4) structures are considered a promising therapeutic target in cancer. Since Ayurveda, Piperine has been known for its medicinal… Continue reading Piperine analogs arrest c-myc gene leading to downregulation of transcription for targeting cancer
Biophysical and functional characterization of the human TAS1R2 sweet taste receptor overexpressed in a HEK293S inducible cell line
2021 / Scientific Reports
Sweet taste perception is mediated by a heterodimeric receptor formed by the assembly of the TAS1R2 and TAS1R3 subunits. TAS1R2… Continue reading Biophysical and functional characterization of the human TAS1R2 sweet taste receptor overexpressed in a HEK293S inducible cell line