2021 / Scientific Report
The C1q superfamily includes proteins involved in innate immunity, insulin sensitivity, biomineralization and more. Among these proteins is otolin-1, which… Continue reading Molecular mechanism of calcium induced trimerization of C1q-like domain of otolin-1 from human and zebrafish
2021 / Scientific Report
Antimicrobial peptides (AMPs) have emerged as a promising alternative to small molecule antibiotics. Although AMPs have previously been isolated in… Continue reading BING, a novel antimicrobial peptide isolated from Japanese medaka plasma, targets bacterial envelope stress response by suppressing cpxR expression
2021 / Nature Communications
Biological membranes play pivotal roles in the cellular activities. Transmembrane proteins are the central molecules that conduct membrane-mediated biochemical functions… Continue reading A synthetic ion channel with anisotropic ligand response
2021 / Scientific Report
AMPA receptors is tightly controlled by a protein group called transmembrane AMPAR regulatory proteins (TARPs). TARP γ-8 (also known as… Continue reading SNP rs10420324 in the AMPA receptor auxiliary subunit TARP γ-8 regulates the susceptibility to antisocial personality disorder
2019 / The Journal of Biological Chemistry, 2012 Mar 16;287(12):9534-46. doi: 10.1074/jbc.M111.333278. Epub 2012 Jan 19.
The inner mitochondrial membrane protein 3β-hydroxysteroid dehydrogenase 2 (3βHSD2) synthesizes progesterone and androstenedione through its dehydrogenase and isomerase activities. This… Continue reading Mitochondrial 3β-hydroxysteroid dehydrogenase enzyme activity requires reversible pH-dependent conformational change at the intermembrane space
2020 / Photochemical and Photobiological Sciences
We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion,… Continue reading Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles
2021 / Fitoterapia
Phytochemical investigation on the aerial parts of a Lamiaceous medicinal plant Perovskia scrophulariifolia collected in Uzbekistan resulted in the isolation… Continue reading Diterpenes from an Uzbek medicinal plant Perovskia scrophulariifolia: Their structures and anti-neuroinflammatory activity
2021 / Nature Communications
In living organisms, proteins are organized prevalently through a self-association mechanism to form dimers and oligomers, which often confer new… Continue reading Dimerization and oligomerization of DNA-assembled building blocks for controlled multi-motion in high-order architectures
2021 / Nature Communications
Chaperones Tapasin and TAP-binding protein related (TAPBPR) perform the important functions of stabilizing nascent MHC-I molecules (chaperoning) and selecting high-affinity… Continue reading TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap
2021 / Nature Communications
Despite great challenges, the development of new molecular structures with multiple and even conflicting characteristics are eagerly pursued for exploring… Continue reading π-Extended perylene diimide double-heterohelicenes as ambipolar organic semiconductors for broadband circularly polarized light detection
2021 / Scientific Report
The Pacific oyster, Crassostrea gigas, is a traditional food worldwide. The soft body of the oyster can easily accumulate heavy… Continue reading Identification and functional analysis of cadmium-binding protein in the visceral mass of Crassostrea gigas
2021 / Biointerface Research in applied Chemistry
Trichoderma genus fungi present great potential for the production of carbohydrate-active enzymes (CAZYmes), including glycoside hydrolase (GH) family members. From… Continue reading A novel fungal metal-dependent α-l-arabinofuranosidase of family 54 glycoside hydrolase shows expanded substrate specificity
2021 / Scientific Report
Two-component systems (TCS) are widespread signaling systems present in all domains of life. TCS typically consist of a signal receptor/transducer… Continue reading Molecular model of a sensor of two-component signaling system
2021 / Chemical Society of Japan Journals
Electronic structures and direct observation of adlayers on Au(111) of triangular expanded hemiporphyrazines that can be classified into azaporphyrinoids and… Continue reading Triangular Expanded Hemiporphyrazines: Electronic Structures and Nanoscale Characterization of Their Adlayers on Au(111)
2021 / MDPI
The aim of this study was to characterize hydrolyzable tannins in Polygonaceous plants, asonly a few plants have previously been… Continue reading Ellagitannins and Oligomeric Proanthocyanidins of ThreePolygonaceous Plants
2021 / Nature Communications
Overtemperature-protection intelligent molecular chiroptical photoswitches
2021 / Scientific Report
Protein stability limitations often hamper the exploration of proteins as drug targets. Here, we show that the application of PROSS… Continue reading A PROSS-designed extensively mutated estrogen receptor α variant displays enhanced thermal stability while retaining native allosteric regulation and structure
2021 / Scientific Report
A model legume, Medicago truncatula, has over 600 nodule-specific cysteine-rich (NCR) peptides required for symbiosis with rhizobia. Among them, NCR169,… Continue reading Structure and antimicrobial activity of NCR169, a nodule-specific cysteine-rich peptide of Medicago truncatula
2021 / Scientific Report
Evidence has suggested that major peanut allergen Ara h 1 activates dendritic cells (DCs) via interaction with DC-SIGN (dendritic cell-specific… Continue reading Human monocyte-derived type 1 and 2 macrophages recognize Ara h 1, a major peanut allergen, by different mechanisms
2021 / Scientific Report
Peroxiredoxin 6 (Prdx6), the ubiquitously expressed enzyme belonging to the family of peroxidases, namely, peroxiredoxins, exhibits a unique feature of… Continue reading pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature
