2021 / Nature Communications
Comparative genomic studies have repeatedly shown that new protein-coding genes can emerge de novo from noncoding DNA. Still unknown is… Continue reading Structural and functional characterization of a putative de novo gene in Drosophila
2021 / Nature Communications
Protein–protein interactions (PPIs) between modular binding domains and their target peptide motifs are thought to largely depend on the intrinsic… Continue reading Protein context shapes the specificity of SH3 domain-mediated interactions in vivo
2021 / Nature Communications, 12, Article number: 1530 (2021)
De novo protein design is advancing rapidly. However, most designs are for single states. Here we report a de novo… Continue reading Structural resolution of switchable states of a de novo peptide assembly
2021 / Nature Communications
Modules that switch protein-protein interactions on and off are essential to develop synthetic biology; for example, to construct orthogonal signaling… Continue reading De novo design of a reversible phosphorylation-dependent switch for membrane targeting
2021 / Nature Communications
Minichromosome maintenance protein 10 (MCM10) is essential for eukaryotic DNA replication. Here, we describe compound heterozygous MCM10 variants in patients… Continue reading Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening
2021 / Fitoterapia
Four new lignans, patulinones A−D (1–4) and three new acetophenone derivatives, patulinones E−G (5–7) were isolated from the leaves of… Continue reading New lignans and acetophenone derivatives with α-glucosidase inhibitory activity from the leaves of Melicope patulinervia
2021 / Nature Communications
Biodegradation of aromatic and heterocyclic compounds requires an oxidative ring cleavage enzymatic step. Extensive biochemical research has yielded mechanistic insights… Continue reading Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX
2021 / Communications chemistry
Molecular excitons play a central role in natural and artificial light harvesting, organic electronics, and nanoscale computing. The structure and… Continue reading Rotaxane rings promote oblique packing and extended lifetimes in DNA-templated molecular dye aggregates
2021 / Angewandte Chemie International Edition
Multinuclear Ag clusters sandwiched by Pt complex units were synthesized and characterized by single crystal X‐ray diffraction and NMR studies.… Continue reading Multinuclear Ag Clusters Sandwiched by Pt Complex Units: Fluxional Behavior and Chiral‐at‐Cluster Photoluminescence
2021 / Marine Drugs
Chemical investigation of secondary metabolites from the marine-derived fungus Aspergillus austroafricanus Y32-2 resulted in the isolation of two new prenylated… Continue reading New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2
2021 / Fitoterapia
Four new lignans, patulinones A−D (1–4) and three new acetophenone derivatives, patulinones E−G (5–7) were isolated from the leaves of… Continue reading New lignans and acetophenone derivatives with α-glucosidase inhibitory activity from the leaves of Melicope patulinervia
2021 / Nature Communications
The endoplasmic reticulum (ER) network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs.… Continue reading Mechanism of membrane-curvature generation by ER-tubule shaping proteins
2021 / Communication Biology
The thermodynamic hypothesis of protein folding, known as the “Anfinsen’s dogma” states that the native structure of a protein represents… Continue reading Breakdown of supersaturation barrier links protein folding to amyloid formation
2021 / Communication Biology
The macro domain is an ADP-ribose (ADPR) binding module, which is considered to act as a sensor to recognize nicotinamide… Continue reading Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites
2021 / Nature Communications
ATP-independent chaperones are usually considered to be holdases that rapidly bind to non-native states of substrate proteins and prevent their… Continue reading Mechanism of the small ATP-independent chaperone Spy is substrate specific
2021 / Nature Communications
Recent advances in computational methods have enabled the predictive design of self-assembling protein nanomaterials with atomic-level accuracy. These design strategies… Continue reading Complete and cooperative in vitro assembly of computationally designed self-assembling protein nanomaterials
2021 / Nature Communications
Controlling nanocarrier interactions with the immune system requires a thorough understanding of the surface properties that modulate protein adsorption in… Continue reading Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets
2021 / Nature Communications
The Hsp40/Hsp70 chaperone families combine versatile folding capacity with high substrate specificity, which is mainly facilitated by Hsp40s. The structure… Continue reading Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone
2021 / Communication Biology
In light of the recent accumulated knowledge on SARS-CoV-2 and its mode of human cells invasion, the binding of viral… Continue reading Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection
2021 / Nature Communications
Adenosine-to-inosine (A-to-I) editing of eukaryotic cellular RNAs is essential for protection against auto-immune disorders. Editing is carried out by ADAR1,… Continue reading Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions
