2016 / Organic and Biomolecular Chemistry
The conformational attributes of proline can have a substantial effect on the folding of polypeptide chains into a native structure… Continue reading Replacing a single atom accelerates the folding of a protein and increases its thermostability
2016 / International Journal of Biological Macromolecules
The folding and unfolding mechanisms of a small monomeric protein, Dihydrofolate reductase (1.5.1.3.) from a new variant, Zebrafish (zDHFR) has been studied through GdnHCl… Continue reading Investigation of folding unfolding process of a new variant of dihydrofolate reductase protein from Zebrafish
2016 / Inorganica Chimica Acta
Assemblies between the pseudo-enantiomers with different π electronic systems, [Pt(bpy){Co(d-pen)2}]+ (bpy = 2,2′-bipyridine, pen = penicillaminate) and [M(phen){Co(l-pen)2}]+ (M = Pt or Pd, phen = 1,10-phenanthroline), or [Pt(bpy){Co(l-pen)2}]+ and [M(phen){Co(d-pen)2}]+, have… Continue reading Stereospecific interaction of optically active sulfur-bridged dinuclear Co(III)–Pt(II) complex with pseudo-enantiomeric Co(III)–M(II) (M: Pd or Pt) complex involving unequivalent π electronic system
2016 / Journal of Pharmaceutical and Biomedical Analysis
Monoclonal antibody (mAb) drugs constitute the largest class of protein therapeutics currently on the market. Correctly folded protein higher order… Continue reading Simple NMR methods for evaluating higher order structures of monoclonal antibody therapeutics with quinary structure
2016 / European Biophysics Journal
The formation of stable and functional surface layers (S-layers) via self-assembly of surface-layer proteins on the cell surface is a… Continue reading Analysis of self-assembly of S-layer protein slp-B53 from Lysinibacillus sphaericus
2016 / Biophysical Journal
Expansions of polyglutamine (polyQ) tracts in nine different proteins cause a family of neurodegenerative disorders called polyQ diseases. Because polyQ… Continue reading Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract
2016 / Scientific Reports
Eight highly oxygenated germacranolides (1–8) including four new ones (2–5) were isolated from the whole plant of Carpesium divaricatum. The planar… Continue reading New Highly Oxygenated Germacranolides from Carpesium divaricatum and their Cytotoxic Activity
2016 / Physical Chemistry Chemical Physics
The aggregation of amyloid-β (Aβ) on neuronal membranes is implicated in both neuronal toxicity and the progression of Alzheimer’s disease.… Continue reading Biophysical insights into the membrane interaction of the core amyloid-forming Aβ40 fragment K16–K28 and its role in the pathogenesis of Alzheimer’s disease
2016 / Molecular BioSystems
Therapeutic strategies have been reported that depend on synthetic network devices in which a urate-sensing transcriptional regulator detects pathological levels… Continue reading Histidine switch controlling pH-dependent protein folding and DNA binding in a transcription factor at the core of synthetic network devices
2016 / RSC Advances
Microenvironments have been found to play critical roles that cannot be realized in bulk reaction systems. Optically active particles, particularly… Continue reading Micelle-provided microenvironment facilitating the formation of single-handed helical polymer-based nanoparticles
2016 / Journal of Luminescence
The fluorescence quenching of human serum albumin (HSA) by diphthaloylmaslinic acid (FMA) at different pH and temperature values was investigated… Continue reading Simultaneous presence of dynamic and sphere action component in the fluorescence quenching of human serum albumin by diphthaloylmaslinic acid
2016 / Phytochemistry Letters
Five new compounds named penicillars A–E were isolated from the fermentation broth ofPenicillium sp. SCS-KFD08 associated with the marine animal Sipunculus nudus from… Continue reading Penicillars A–E from the marine animal endogenic fungusPenicillium sp. SCS-KFD08
2016 / Phytochemistry Letters
The phytochemical study on the root bark of Erythrina livingstoniana has led to the isolation of two new isoflavans namely 7-hydroxy-2′-methoxy-[6′′,6′′-dimethylpyrano (2′′,3′′:4′,5′)]isoflavan… Continue reading New isoflavans from the root bark of Erythrina livingstoniana
2016 / Marine Drugs
Three new meroterpenoids, named austalides S-U (1–3), were isolated from the culture of a sponge-derived fungus Aspergillus aureolatus HDN14-107, together with eleven… Continue reading Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107
2016 / PLoS ONE
Unlike the genomes of many mammals that have a single NK-lysin gene, the cattle genome contains a family of four genes, one… Continue reading Expression of the Bovine NK-Lysin Gene Family and Activity against Respiratory Pathogens
2016 / RSC Advances
A series of poly(L-glutamate) bearing Y-shaped oligo(ethylene glycol)x (OEGx) side-chains (PPLG-g-EGx, x = 2, 3 and 4) were synthesized via… Continue reading Biodegradable Thermal- and Redox-Responsive Poly(L-glutamate) with Y-shaped Oligo(ethylene glycol) Side-chain and Tunable Phase Transition Temperature
2016 / Journal of Pharmaceutical and Biomedical Analysis
Two new homoisoflavonoids, dracaeconolide A (1) and dracaeconolide B (2), together with ten known compounds, namely (3R)-7,4′-dihydroxy-8-methoxyhomoisoflavane (3), (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane (4),… Continue reading Isolation and chatacterization of homoisoflavonoids fromDracaena cochinchinensis and their osteogenic activities in mouse mesenchymal stem cells
2014 / Colloids and Surfaces B: Biointerfaces
Dendrimers’ action on proteins and peptides has a dual and controversial character. On one hand, they dissolve prion protein and… Continue reading Stabilizing effect of small concentrations of PAMAM dendrimers at the insulin aggregation
2014 / Physical Chemistry Chemical Physics
Enzymatic regulation is a fast and reliable diagnosis tool via identification and design of inhibitors for modulation of enzyme function. Previous reports… Continue reading Modulation of glyceraldehyde-3-phosphate dehydrogenase activity by surface functionalized quantum dots
2012 / Journal of Colloid and Interface Science
Gemini surfactants have two polar head groups and two hydrocarbon tails. Compared with conventional surfactants, geminis have much lower (μM… Continue reading Interactions of gemini surfactants with two model proteins: NMR, CD, and fluorescence spectroscopies
