Fluorescence, absorption, time-correlated single photon counting (TCSPC), and circular dichroism (CD) spectroscopic techniques as well as molecular modeling method were… Continue reading Studies on the interaction between promethazine and human serum albumin in the presence of flavonoids by spectroscopic and molecular modeling techniques
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
HIV-1 Rev protein mediates the nuclear export of viral RNA genomes. To do so, Rev oligomerizes cooperatively onto an RNA… Continue reading The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly
Leah Pandiscia, PhD
July 28, 2017
Amyloids are fibrillar protein superstructures that are commonly associated with diseases in humans and with physiological functions in various organisms. The… Continue reading Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone
Leah Pandiscia, PhD
July 28, 2017
Peroxidase extracted from Momordica charantia catalyzed the H2O2-dependent oxidative coupling of 7-hydroxy-4-methylcoumarin to form four new dimers (1–4) and two known ones… Continue reading α-Glucosidase Inhibitors via Green Pathway: Biotransformation for Bicoumarins Catalyzed by Momordica charantia Peroxidase
Leah Pandiscia, PhD
July 28, 2017
Seven new prieurianin-type limonoids, aphapolynins C–I (1–7), and a new aphanamolide-type limonoid, aphanamolide B (8), along with seventeen known compounds,… Continue reading Limonoids from the Fruits of Aphanamixis polystachya (Meliaceae) and Their Biological Activities
Leah Pandiscia, PhD
July 28, 2017
The solution-dissolved-state circular dichroism (CD) and the circularly polarized luminescence (CPL) of chiral binaphthyl fluorophores was controlled by both the… Continue reading Dependence of circularly polarized luminescence due to the neighboring effects of binaphthyl units with the same axial chirality
Leah Pandiscia, PhD
May 24, 2018
Leah Pandiscia, PhD
July 28, 2017
A versatile and simple methodology for the preparation of well-defined polyglutamate nanocarriers is described. For the first time ammonium salts with non-nucleophilic… Continue reading A controlled and versatile NCA polymerization method for the synthesis of polypeptides
Leah Pandiscia, PhD
July 28, 2017
Apigenin, a natural flavone, present in many plants sources, induced apoptosis and cell death in lung epithelium cancer (A549) cells… Continue reading Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin
Leah Pandiscia, PhD
July 28, 2017
Six new glycosides (1–6) have been isolated from the flower buds of Lonicera japonica. Their structures including the absolute configurations were… Continue reading Aromatic glycosides from the flower buds ofLonicera japonica
Leah Pandiscia, PhD
July 28, 2017
Circular dichroism (CD), defined as the difference in absorption between left and right circularly polarized light, is used to spectroscopically… Continue reading Noise Characterization in Circular Dichroism Spectroscopy
Leah Pandiscia, PhD
July 28, 2017
Two new amide alkaloids, clauemaramide A (1) and clauemaramide B (2), and three known analogs were isolated from the stems… Continue reading Anti-inflammatory amide alkaloids from the stems of Clausena emarginata
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
G-quadruplexes, one of the most significant secondary structure of nucleic acid, are formed by stacking G quartets, which received broad… Continue reading Visualization of G-quadruplexes in gel and in live cells by a near-infrared fluorescent probe
Leah Pandiscia, PhD
July 28, 2017
Four new 13,14-seco-withanolides, minisecolides A-D (1–4), together with three known analogues 5–7, were isolated from the whole plants of Physalis minima. The… Continue reading 13,14-seco-Withanolides from Physalis minima with Potential Anti-inflammatory Activity
Leah Pandiscia, PhD
July 28, 2017
Iridium-based metal complexes containing polypyridyl-pyrazine ligands show properties of DNA intercalation. They serve as roadblocks to DNA polymerase activity, thereby… Continue reading Iridium Complexes as a Roadblock for DNA Polymerase during Amplification
Leah Pandiscia, PhD
July 28, 2017