The interaction of DNA with 5,10,15,20-tetrakis(4-N-methylpyridiniumyl)porphyrin (TMPyP) in polyelectrolyte core-shells obtained via layer by layer adsorption of poly(sodium 4-styrenesulfonate), PSS, and poly(allylamine… Continue reading Design of polyelectrolyte core-shells with DNA to control TMPyP binding
Leah Pandiscia, PhD
July 28, 2017
A series of cationic peptides with alternated lysines and hydrophobic residues were designed and synthesized. This kind of short peptides… Continue reading Heteropoly acids triggered self-assembly of cationic peptides into photo- and electro-chromic gels
Leah Pandiscia, PhD
July 28, 2017
Human phospholipid scramblase 1 (hPLSCR1) was initially identified as a Ca2+ dependent phospholipid translocator involved in disrupting membrane asymmetry. Recent reports… Continue reading Identification and characterization of the novel nuclease activity of human phospholipid scramblase 1
Leah Pandiscia, PhD
July 28, 2017
An internally duplicated α-type carbonic anhydrase (CA) from Dunaliella species (Dsp-CA) has been expressed as single-domain derivatives, N- and C- half domains.… Continue reading Chimeric protein of internally duplicated α-type carbonic anhydrase from Dunaliella species for improved expression and CO2 sequestration
Leah Pandiscia, PhD
July 28, 2017
YtvA is a blue light sensor protein composed of an N-terminal LOV (Light–Oxygen–Voltage) domain, a linker helix, and the C-terminal… Continue reading Photochemical reactions of the LOV and the LOV-linker domains of the blue light sensor protein YtvA
Leah Pandiscia, PhD
July 28, 2017
Five new polycyclic polyprenylated acylphloroglucinols (1–5) with a bicyclo[3.3.1]nonane skeleton, along with five known analogues (6–10), were isolated from the… Continue reading Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols fromHypericum sampsonii
Leah Pandiscia, PhD
July 28, 2017
Transmembrane β-peptide helices and their association in lipid membranes are still widely unexplored. We designed and synthesized transmembrane β-peptides harboring… Continue reading β-Glutamine-mediated Self-Association of Transmembrane β- Peptides within Lipid Bilayers
Leah Pandiscia, PhD
July 28, 2017
Small molecules arresting G-quadruplex structure has become a potential strategy for the development and designing of new class of anticancer… Continue reading Myricetin arrests Human Telomeric G-quadruplex structure: A new mechanistic approach as an anticancer agent
Leah Pandiscia, PhD
July 28, 2017
Endoglucanases are the main cellulolytic enzymes secreted by the bacteriumXanthomonas campestris pv. campestris (Xcc). The major endoglucanase exported by this bacterium into external… Continue reading Biophysical and biochemical studies of a major endoglucanase secreted by Xanthomonas campestris pv. campestris.
Leah Pandiscia, PhD
July 28, 2017
Protein structure dynamics are critical for understanding structure-function relationships. An antibody can recognize its antigen, and can evolve toward the… Continue reading Structural dynamics of a single-chain Fv antibody against (4-hydroxy-3-nitrophenyl)acetyl
Leah Pandiscia, PhD
July 28, 2017
The biosimilar industry is witnessing an unprecedented growth with the newer therapeutics increasing in complexity over time. A key step… Continue reading Assessing analytical comparability of Biosimilars: GCSF as a case study
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
IgG is an important defence protein. To exhibit optimum function the molecule must maintain its native structure. Peroxynitrite is a… Continue reading Peroxynitrite-induced structural perturbations in human IgG: A physicochemical study
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
May 24, 2018
Dual targeting towards both extracellular and intracellular receptors specific to tumor is a significant approach for cancer diagnosis and therapy.… Continue reading Dual targeting luminescent gold nanoclusters for tumor imaging and deep tissue therapy
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The X-linked AIFM1 gene encodes mitochondrial apoptosis-inducing factor (AIF), an FAD-containing and NADH-specific oxidoreductase critically important for energy metabolism and execution of… Continue reading Structure/function relations in AIFM1 variants associated with neurodegenerative disorders
Leah Pandiscia, PhD
July 28, 2017
The present investigation of the chemical constituents of the stem barks of Ailanthus altissima has resulted in the isolation of six canthinone-type… Continue reading A New Canthinone-Type Alkaloid Isolated from Ailanthus altissima Swingle
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Hemicelluloses are the second major polysaccharides in nature and can be converted to ethanol product by a variety of enzymes… Continue reading Loops Adjacent to Catalytic Region and Molecular Stability of Man1312
Leah Pandiscia, PhD
July 28, 2017