2016 / Biosensors and Bioelectronics
The novel iridium(III) complex 1 was found to be highly selective for G-quadruplex DNA, and was employed for the development of a… Continue reading A versatile nanomachine for the sensitive detection of platelet-derived growth factor-BB utilizing a G-quadruplex-selective iridium(III) complex
2016 / Journal of Photochemistry and Photobiology B: Biology
This study describes HSA binding properties of a platinum(II) complex with an antiviral drug ligand; ribavirin. Spectroscopic analysis of the… Continue reading Biophysical studies on the interaction of platinum(II) complex containing antiviral drug ribavirin with human serum albumin
2016 / Journal of Photochemistry and Photobiology B: Biology
Aspergillosis is one of the infectious fungal diseases affecting mainly the immunocompromised patients. The scarcity of the antifungal targets has… Continue reading Binding mode of dihydroquinazolinones with lysozyme and its antifungal activity against Aspergillus species
2016 / Biochemistry and Biophysics Reports
Interactions between enamel matrix proteins are important for enamel biomineralization. In recent in situ studies, we showed that the N-terminal proteolytic product… Continue reading Ameloblastin peptide encoded by exon 5 interacts with amelogenin N-terminus
2016 / Carbohydrate Polymers
Here, we demonstrate a successful synthesis of bio-based aldehyde namely dialdehyde-carboxymethylagarose (DCMA) using carboxymethyagarose (CMA). Further reaction parameters (i.e. reaction… Continue reading Synthesis of bio-based aldehyde from seaweed polysaccharide and its interaction with bovine serum albumin
2016 / Protein Expression and Purification
Human gelatinase (MMP-9) is a member of matrix metalloproteinases family (MMPs), which has been associated with malignant tumor progression and… Continue reading Expression, purification, refolding and in vitro recovery of active full length recombinant human gelatinase MMP-9 in Escherichia coli
2016 / Bioorganic and Medicinal Chemistry
Two new cystine knot peptides, asteropsins F (ASPF) and G (ASPG), were isolated from the marine sponge Asteropus sp. ASPF and ASPG… Continue reading Stable and biocompatible cystine knot peptides from the marine sponge Asteropus sp.
2016 / European Journal of Medicinal Chemistry
Ligand conjugation to oligonucleotides is an attractive strategy for enhancing the therapeutic potential of antisense and siRNA agents by inferring… Continue reading Fragment-based solid-phase assembly of oligonucleotide conjugates with peptide and polyethylene glycol ligands
2013 / Analytical Biochemistry
Optical and vibrational spectroscopic techniques are important tools for evaluating secondary and tertiary structures of proteins. These spectroscopic techniques are… Continue reading Comparison of quantitative spectral similarity analysis methods for protein higher-order structure confirmation
2016 / Nucleic Acids Research
i-Motifs are four-stranded DNA structures consisting of two parallel DNA duplexes held together by hemi-protonated and intercalated cytosine base pairs… Continue reading Stabilization of i-motif structures by 2′-β-fluorination of DNA
2016 / vaccines
Two HIV-1 subtype C gp120 protein candidates were the selected antigens for several experimental vaccine regimens now under evaluation in… Continue reading Comprehensive Characterization of Reference Standard Lots of HIV-1 Subtype C Gp120 Proteins for Clinical Trials in Southern African Regions
2016 / Dyes and Pigments
Bottom-up fabrication of functional supramolecular systems from discrete molecular building blocks is a flourishing endeavor in contemporary science and nanotechnology.… Continue reading Photo and redox dual-stimuli-directed reversible disassembly and reassembly of linear supramolecular polymer formed by orthogonal host-guest molecular recognition
2016 / The Journal of Biological Chemistry
Phosphatidyl-myo-inositol mannosyltransferase A (PimA) is an essential glycosyltransferase (GT) that initiates the biosynthetic pathway of phosphatidyl-myo-inositol mannosides (PIMs), lipomannan (LM)… Continue reading Molecular basis of membrane association by the phosphatidylinositol mannosyltransferase PimA from mycobacteria
2016 / International Journal of Biological Macromolecules
Sheep serum albumin (SSA) is a 583 amino acid residues long multidomain monomeric protein which is rich in cysteine and… Continue reading Characterisation of Molten Globule-like State of Sheep Serum Albumin at Physiological pH
2016 / Bioelectrochemistry
Cell phones increase exposure to radiofrequency (RF) electromagnetic fields (EMFs). Whether EMFs exert specific effects on biological systems remains debatable.… Continue reading Effects of 3G cell phone exposure on the structure and function of the human cytochrome P450 reductase
2016 / Journal of Biochemical and Molecular Toxicology
In this paper, we use spectroscopic methods (fluorescence spectroscopy, UV absorption spectroscopy, and circular dichroism (CD) spectroscopy) to elucidate the… Continue reading Effects of γ-Irradiation on the Molecular Structures and Functions of Human Serum Albumin
2016 / Molecular Nutrition & Food Research
Iron is an essential nutrient. However, in animal models, excess unabsorbed dietary iron residing within the colonic lumen has been… Continue reading The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health
2016 / Biotechnology and Applied Biochemistry
Endostatin (ES) is an antiangiogenic protein that exhibit antitumor activity in animal models. However, the activity observed in animals was… Continue reading Structural studies of the protein endostatin in fusion with BAX BH3 death domain, a hybrid that present enhanced antitumoral activity
2016 / Biochimica et Biophysica Acta (BBA) - Bioenergetics
Macro-organisation of the protein complexes in plant thylakoid membranes plays important roles in the regulation and fine-tuning of photosynthetic activity.… Continue reading Fingerprinting the macro-organisation of pigment-protein complexes in plant thylakoid membranes in vivo by circular-dichroism spectroscopy
2016 / The Journal of Biological Chemistry
KYE28 (KYEITTIHNLFRKLTHRLFRRNFGYT-LR), the representative sequence of helix D of heparin co-factor II, was demonstrated to be potent against agronomically important… Continue reading Role of Aromatic Amino Acids in Lipopolysaccharide and Membrane Interactions of Antimicrobial Peptides for Use in Plant Disease Control
