Leah Pandiscia, PhD
July 28, 2017
A new xanthone (penicillanthone, 1) and three new diphenyl ether derivatives (penicillidic acids A–C, 2–4) together with 14 known compounds (5–18) were… Continue reading Penicillanthone and penicillidic acids A–C from the soil-derived fungusPenicillium aculeatum PSU-RSPG105
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Chemical epigenetic manipulation was applied to a deep marine-derived fungus, Aspergillus sp. SCSIOW2, resulting in significant changes of the secondary metabolites. Three… Continue reading Eremophilane Sesquiterpenes from a Deep Marine-Derived Fungus, Aspergillussp. SCSIOW2, Cultivated in the Presence of Epigenetic Modifying Agents
Leah Pandiscia, PhD
July 28, 2017
Biosensors based on the localized surface plasmon resonance (LSPR) of individual metallic nanoparticles promise to deliver modular, low-cost sensing with… Continue reading Dispersion and shape engineered plasmonic nanosensors
Leah Pandiscia, PhD
July 28, 2017
Food texture can be improved by enzyme-mediated covalent cross-linking of different food components, such as proteins and carbohydrates. Cross-linking changes… Continue reading Peanut protein structure, polyphenol content and immune response to peanut proteins in vivo are modulated by laccase
Leah Pandiscia, PhD
July 28, 2017
The dibromido analogue of cisplatin, cis-PtBr2(NH3)2 (cisPtBr2 hereafter), has been prepared and characterised. Its solution behaviour in standard phosphate buffer, at pH 7.4,… Continue reading Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles
Leah Pandiscia, PhD
July 28, 2017
There is an escalating interest of using double stranded DNA molecules as a chiral scaffold to construct metal-biomacromolecule hybrid catalysts… Continue reading G-quadruplex DNA-based asymmetric catalysis of michael addition: Effects of sonication, ligands, and co-solvents
Leah Pandiscia, PhD
July 28, 2017
Acetaminophen, a widely used analgesic and antipyretic drug has ample affinity to bind globular proteins. Here, we have illustrated a… Continue reading Acetaminophen interacts with Human Hemoglobin: Optical, Physical and Molecular modeling studies.
Leah Pandiscia, PhD
July 28, 2017
Carbonic anhydrase IX (CAIX) is a transmembrane glycoprotein, associated with tumor, acidification which leads to the cancer, and is considered… Continue reading GdmCl-induced unfolding studies of human carbonic Anhydrase IX: A combined spectroscopic and MD simulation approach
Leah Pandiscia, PhD
July 28, 2017
Parasites belonging to the genus Leishmania are subjected to extensive environmental changes during their life cycle; molecular chaperones/co-chaperones act as protagonists in… Continue reading Low sequence identity but high structural and functional conservation: The case of Hsp70/Hsp90 organizing protein (Hop/Sti1) of Leishmania braziliensis
Leah Pandiscia, PhD
July 28, 2017
Topology of amphiphiles is important to control physicochemical properties of supramolecular assemblies. Nature demonstrates higher stability of membrane composed of… Continue reading Contrasting Topological Effect of PEG-Containing Amphiphiles to Natural Lipids on Stability of Vesicles
Leah Pandiscia, PhD
July 28, 2017
RNase P is an essential enzyme that processes 5′ end leader sequence of pre-tRNA to generate mature tRNA. The bacterial… Continue reading Influence of Conformation of M. tuberculosis RNase P Protein Subunit on Its Function
Leah Pandiscia, PhD
July 28, 2017
In this study, we developed horseradish peroxidase (HRP)-catalyzed sprayable gelatin hydrogels (GH) as a bioactive wound dressing that can deliver… Continue reading Cell recruiting chemokine-loaded sprayable gelatin hydrogel dressings for diabetic wound healing
Leah Pandiscia, PhD
July 28, 2017
To the best of our knowledge, this is the first report of a self-assembling orbitide that is capable of forming… Continue reading Self-assembled fibrillar networks comprised of a naturally-occurring cyclic peptide—LOB3
Leah Pandiscia, PhD
July 28, 2017
Oleic acid (OA) complexes of human alpha-lactalbumin (α-LA) and several other proteins are effective in the killing of a variety… Continue reading Behaviour of oleic acid-depleted bovine alpha-lactalbumin made LEthal to tumor cells (BAMLET)
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Nine new sesquiterpenoids, clitocybulol derivatives, clitocybulols G–O (1–9) and three known sesquiterpenoids, clitocybulols C–E (10 − 12), were isolated from the solid… Continue reading New sesquiterpenoids from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against α-glucosidase and PTP1B
Leah Pandiscia, PhD
July 28, 2017
This paper reports a new and facile method for the synthesis of water-soluble thiolate-protected AuNCs via protein-ligand interaction. Using 3-mercaptopropionic acid (MPA)… Continue reading Water-soluble gold nanoclusters prepared by protein-ligand interaction as fluorescent probe for real-time assay of pyrophosphatase activity
Leah Pandiscia, PhD
July 28, 2017
Alkaline phosphatase is a homodimeric metallo-hydrolase where both Zn2+ and Mg2+ are important for catalysis and stability. Cold-adapted alkaline phosphatase variants have… Continue reading Cold-active alkaline phosphatase is irreversibly transformed into an inactive dimer by low urea concentrations
Leah Pandiscia, PhD
July 28, 2017
