• Year

  • Technique

  • Industry

Design and synthesis of a novel fluorescent benzo[g]imidazo[4,5-c]quinoline nucleoside for monitoring base-pair-induced protonation with cytosine: distinguishing cytosine via changes in the intensity and wavelength of fluorescence

2016 / Organic and Biomolecular Chemistry

A novel fluorescent benzo[g]imidazo[4,5-c]quinoline nucleoside BIQA (1) comprising a 3-deaza-2′-deoxyadenosine skeleton was developed and used to monitor BIQA–C base-pair formation in oligodeoxynucleotide (ODN)… Continue reading Design and synthesis of a novel fluorescent benzo[g]imidazo[4,5-c]quinoline nucleoside for monitoring base-pair-induced protonation with cytosine: distinguishing cytosine via changes in the intensity and wavelength of fluorescence

Leah Pandiscia, PhD July 28, 2017

Recombinant preparation and functional studies of EspI ATP binding domain from Mycobacterium tuberculosis

2016 / Protein Expression and Purification

The ESX-1 secretion system of Mycobacterium tuberculosis is required for the virulence of tubercle bacillus. EspI, the ESX-1 secretion-associated protein in Mycobacterium tuberculosis (MtEspI),… Continue reading Recombinant preparation and functional studies of EspI ATP binding domain from Mycobacterium tuberculosis

Leah Pandiscia, PhD July 28, 2017

Advanced glycation end products induce differential structural modifications and fibrillation of albumin

2016 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Glycation induced amyloid fibrillation is fundamental to the development of many neurodegenerative and cardiovascular complications. Excessive non-enzymatic glycation in conditions… Continue reading Advanced glycation end products induce differential structural modifications and fibrillation of albumin

Leah Pandiscia, PhD July 28, 2017

Detailed functional analysis of two clinical glucose-6-phosphate dehydrogenase (G6PD) variants, G6PDViangchan and G6PDViangchan + Mahidol: Decreased stability and catalytic efficiency contribute to the clinical phenotype

2016 / Molecular Genetics and Metabolism

Deficiency of glucose-6-phosphate dehydrogenase (G6PD) is an X-linked hereditary genetic defect that is the most common polymorphism and enzymopathy in… Continue reading Detailed functional analysis of two clinical glucose-6-phosphate dehydrogenase (G6PD) variants, G6PDViangchan and G6PDViangchan + Mahidol: Decreased stability and catalytic efficiency contribute to the clinical phenotype

Leah Pandiscia, PhD July 28, 2017

Increasing the Net Negative Charge by Replacement of DOTA Chelator with DOTAGA Improves the Biodistribution of Radiolabeled Second-Generation Synthetic Affibody Molecules

2016 / Molecular Pharmaceutics

A promising strategy to enable patient stratification for targeted therapies is to monitor the target expression in a tumor by… Continue reading Increasing the Net Negative Charge by Replacement of DOTA Chelator with DOTAGA Improves the Biodistribution of Radiolabeled Second-Generation Synthetic Affibody Molecules

Leah Pandiscia, PhD July 28, 2017

Formation scheme and antioxidant activity of a novel Maillard pigment, pyrrolothiazolate, formed from cysteine and glucose

2016 / Food and Function

We recently identified 6-hydroxy-3[R],7a[S]-dimethyl-7-oxo-2,3-dihydropyrrolo[2,1-b]thiazole-3-calboxylic acid, a novel pyrrolothiazole derivative carrying a carboxy group and named pyrrolothiazolate, as a Mallard pigment… Continue reading Formation scheme and antioxidant activity of a novel Maillard pigment, pyrrolothiazolate, formed from cysteine and glucose

Leah Pandiscia, PhD July 28, 2017

The novel R347g pathogenic mutation of aromatic amino acid decarboxylase provides additional molecular insights into enzyme catalysis and deficiency

2016 / Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics

We report here a clinical case of a patient with a novel mutation (Arg347 → Gly) in the gene encoding aromatic amino… Continue reading The novel R347g pathogenic mutation of aromatic amino acid decarboxylase provides additional molecular insights into enzyme catalysis and deficiency

Leah Pandiscia, PhD July 28, 2017

Binding of fluorescent acridine dyes acridine orange and 9-aminoacridine to hemoglobin: Elucidation of their molecular recognition by spectroscopy, calorimetry and molecular modeling techniques

2016 / Journal of Photochemistry and Photobiology B: Biology

The molecular interaction between hemoglobin (HHb), the major human heme protein, and the acridine dyes acridine orange (AO) and 9-aminoacridine… Continue reading Binding of fluorescent acridine dyes acridine orange and 9-aminoacridine to hemoglobin: Elucidation of their molecular recognition by spectroscopy, calorimetry and molecular modeling techniques

Leah Pandiscia, PhD July 28, 2017