2016 / Structure
The Lon AAA+ protease (LonA) is an evolutionarily conserved protease that couples the ATPase cycle into motion to drive substrate… Continue reading Structural Insights into the Allosteric Operation of the Lon AAA+ Protease
2016 / Biophysical Journal
Denaturant-induced unfolding of helical membrane proteins provides insights into their mechanism of folding and domain organization, which take place in… Continue reading Reversible Unfolding of Rhomboid Intramembrane Proteases
2016 / Journal of Electroanalytical Chemistry
A novel bio-electrochemical immunosensor for sensitive and selective detection of anti-peptide antibodies of HPV was fabricated by immobilization of a… Continue reading Development of a bio-electrochemical immunosensor based on the immobilization of SPINNTKPHEAR peptide derived from HPV-L1 protein on a gold electrode surface
2016 / Soft Matter
The self-assembly of peptide amphiphiles (PAs) is found to be governed by the hydrophobic interactions induced by the hydrophobic groups/number… Continue reading Exploring Architectures at the Nanoscale: The Interplay of Hydrophobic Twin Lipid Chain and Headgroups of Designer Peptide Amphiphiles in the Self-Assembly Process and Application
2016 / The Journal of Peptide Science
Elastin, a core protein of the elastic fibers, exhibits the coacervation (temperature-dependent reversible association/dissociation) under physiological conditions. Because of this… Continue reading Dimerization effects on coacervation property of an elastin-derived synthetic peptide (FPGVG)5
2016 / European Biophysics Journal
Advanced glycation end products (AGEs) as a result of Maillard reaction are currently at the heart of the pathogenesis of… Continue reading Aggregation as a consequence of glycation: insight into the pathogenesis of arthritis
2016 / Journal of Polymer Science Part A
Ring opening polymerization (ROP) of N-carboxy anhydride (NCA) amino acids presents a rapid way to synthesize high molecular weight polypeptides… Continue reading Tuning the conformation of synthetic co-polypeptides of serine and glutamic acid through control over polymer composition
2016 / Biotechnologically Relevant Enzymes and Proteins
Napin and napin-like proteins belong to the 2S albumin seed storage family of proteins and have been shown to display… Continue reading Structural and functional characterization of recombinant napin-like protein of Momordica charantiaexpressed in methylotrophic yeast Pichia pastoris
2016 / Journal of Biochemical and Molecular Toxicology
The interaction between acotiamide hydrochloride and pepsin was systematically characterized by fluorescence and electrochemical approaches. Fluorescence lifetime measurements showed that… Continue reading Probing the Interaction between Acotiamide Hydrochloride and Pepsin by Multispectral Methods, Electrochemical Measurements, and Docking Studies
2016 / Biochemistry
Electrospray ionization mass spectrometry (ESI-MS) combined with fluorescence, circular dichroism, UV spectrophotometer, and native polyacrylamide gel electrophoresis techniques are used… Continue reading Sequence Effect on the Topology of 3 + 1 Interlocked Bimolecular DNA G-quadruplexes
2016 / The FEBS Journal
The A-kinase anchoring protein (AKAP) smAKAP has three extraordinary features; it is very small, it is anchored directly to membranes… Continue reading Structure of smAKAP and its regulation by PKA-mediated phosphorylation
2016 / Analytical Chemistry
2′-O-(1-Pyrenylmethyl)uridine modified oligoribonucleotides provide highly sensitive pyrene fluorescent probes for detecting specific nucleotide mutation of RNA targets. To develop more… Continue reading Microenvironmental Effect of 2′-O-(1-Pyrenylmethyl)uridine Modified Fluorescent Oligonucleotide Probes on Sensitive and Selective Detection of Target RNA
2016 / Journal of Pharmaceutical Sciences
Amyloid fibrils are β-sheet-rich protein aggregates that are associated with more than 20 diseases. Insulin is known to form amyloid… Continue reading Characterization of Novel Insulin Fibrils That Show Strong Cytotoxicity Under Physiological pH
2016 / Polyhedron
Using the enantiopure bis-bidentate ligands (−)/(+)-2,5-bis(4,5-pinene-2-pyridyl)pyrazine (LR/LS), two mono- and dinuclear SmIII enantiomeric pairs with the formulae [Sm(dbm)3LR/S]·C2H6CO·H2O (R-1 and S-1 being the isomers… Continue reading Homochiral mono- and dinuclear SmIII complexes showing the effect of nuclearity on their photophysical properties
2016 / PLoS ONE
Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness among people over the age of 60.… Continue reading Anti-Human VEGF Repebody Effectively Suppresses Choroidal Neovascularization and Vascular Leakage
2016 / Journal of Inorganic Biochemistry
The vascular endothelial growth factor A (VEGF-A) is a potent angiogenic factor, its activity may be influenced by the presence… Continue reading The Inorganic Perspective of VEGF: Interactions of Cu2 + with Peptides Encompassing a Recognition Domain of the VEGF Receptor
2016 / Biochimica et Biophysica Acta-Biomembranes
The first step of cell membrane penetration of arginine peptides is thought to occur via electrostatic interactions between positive charges… Continue reading Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides
2016 / Journal of Photochemistry and Photobiology B: Biology
Three metal complexes (1–3) of the type [Mn(acac)2(py)·H2O] (1), [Co(acac)2(py)·H2O] (2) and [Zn(acac)2(py)·H2O] (3), [Where acac = acetylacetone, py = pyridine] were synthesized and… Continue reading Synthesis, interactions, molecular structure, biological properties and molecular docking studies on Mn, Co, Zn complexes containing acetylacetone and pyridine ligands with DNA duplex
2016 / Internation Journal of Pharmaceutics
The monoclonal antibody infliximab is one of the cornerstones in the treatment of Crohn’s disease. Local delivery of infliximab would… Continue reading Development and potential application of an oral ColoPulse infliximab tablet with colon specific release: A feasibility study
2016 / Protein Expression and Purification
The major protease inhibitor from the sea anemone Stichodactyla helianthus (ShPI-1) is a non-specific inhibitor that binds trypsin and other trypsin-like enzymes,… Continue reading Two variants of the major serine protease inhibitor from the sea anemone Stichodactyla helianthus, expressed in Pichia pastoris
