Leah Pandiscia, PhD
July 28, 2017
Newly discovered active macromolecules are highly promising for therapy, but poor bioavailability hinders their oral use. Microencapsulation approaches, such as… Continue reading On prilled Nanotubes-in-Microgel Oral Systems for protein delivery
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The major goal of this study was to develop the biodegradable and biocompatible thermosensitive polylactic acid–polyethylene glycol–polylactic acid triblock copolymer-based… Continue reading Basal level insulin delivery: In vitro release, stability, biocompatibility, and in vivo absorption from thermosensitive triblock copolymers
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
wo major aggregation pathways observed in an IgG2 molecule are described. Different aggregate species generated by long-term incubation of the… Continue reading Elucidation of Two Major Aggregation Pathways in an IgG2 Antibody
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Silicone oil, which is used as a lubricant or coating in devices such as syringes, needles and pharmaceutical containers, has… Continue reading Silicone Oil- and Agitation-Induced Aggregation of a Monoclonal Antibody in Aqueous Solution
Leah Pandiscia, PhD
July 28, 2017
We studied the physical and biophysical affects of the nonionic surfactants polysorbate 20 and 80 and their mechanism of interaction… Continue reading Physical and biophysical effects of polysorbate 20 and 80 on darbepoetin alfa
Leah Pandiscia, PhD
July 28, 2017
ApoA-I mimetics are short synthetic peptides that contain an amphipathic α-helix and stimulate cholesterol efflux by the ABCA1 transporter in… Continue reading Amphipathic polyproline peptides stimulate cholesterol efflux by the ABCA1 transporter
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The misfolding of the prion protein (PrP) to aggregated forms is linked to several neurodegenerative diseases. Misfolded oligomeric forms of… Continue reading Unraveling the Molecular Mechanism of pH-Induced Misfolding and Oligomerization of the Prion Protein
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Bovine α-lactalbumin (α-La) and lysozyme (Lys), two globular proteins with highly homologous tertiary structures and opposite isoelectric points, were used… Continue reading Design of bio-based supramolecular structures through self-assembly of α-lactalbumin and lysozyme
Leah Pandiscia, PhD
July 28, 2017
In the search for novel platinum-based anticancer therapeutic agents, we have recently established a structural motif of (O,S) bidentate ligands… Continue reading Elucidating the reactivity of Pt(II) complexes with (O,S) bidentate ligands towards DNA model systems ☆
Leah Pandiscia, PhD
July 28, 2017
At least 30 different human proteins can fold abnormally to form the amyloid deposits that are associated with a number… Continue reading Amyloid fibrillogenesis of lysozyme is suppressed by a food additive brilliant blue FCF
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Tedizolid is the newest antibacterial agent from the oxazolidinone class. For its identification, FT-IR (2000–400 cm−1) and Raman (2000–400 cm−1) analyses were… Continue reading Infrared, Raman and ultraviolet with circular dichroism analysis and theoretical calculations of tedizolid
Leah Pandiscia, PhD
July 28, 2017
We have obtained a chimeric protein containing the ectodomains of hepatitis C virus (HCV) envelope proteins but lacking the region… Continue reading The deletion of residues 268-292 of E1 impairs the ability of HCV envelope proteins to induce pore formation
Leah Pandiscia, PhD
July 28, 2017
Mast cells are involved in allergic responses and undergo exocytotic release of inflammatory mediators in response to antigen stimulation. Soluble N-ethylmaleimide-sensitive… Continue reading Effect of Complexin II on Membrane Fusion between Liposomes Containing Mast Cell SNARE Proteins
Leah Pandiscia, PhD
July 28, 2017
