2020 / Scientific Reports
The spread of multi-drug resistance and the slow pace at which antibiotics come onto the market are undermining our ability… Continue reading Physicochemical-guided design of cathelicidin-derived peptides generates membrane active variants with therapeutic potential
2020 / International Journal of Biological Macromolecules
Thermotoga maritima Arginine Binding Protein has been extensively characterized because of its peculiar features and its possible use as a biosensor.… Continue reading Guanidinium binding to proteins: The intriguing effects on the D1 and D2 domains of Thermotoga maritima Arginine Binding Protein and a comprehensive analysis of the Protein Data Bank
2020 / International Journal of Biological Macromolecules
Chironomids are an abundant group of aquatic silk spinning insects. They offer a unique opportunity of silk harvestation without killing… Continue reading Structural and physical analysis of underwater silk from housing nest composites of a tropical chironomid midge
2020 / Archives of Biochemistry and Biophysics
Oxidative stress is proposed to be one of the major causes of neurodegenerative diseases. Cellular prion protein (PrP) oxidation has… Continue reading Evidence of conformational landscape alteration and macromolecular complex formation in the early stages of in vitro human prion protein oxidation
2020 / Nucleic Acids Research
tRNAs are the most highly modified RNAs in all cells, and formation of 5-methyluridine (m5U) at position 54 in the… Continue reading The methyltransferase TrmA facilitates tRNA folding through interaction with its RNA-binding domain
2020 / Journal of Natural Products
Two dimeric cassane diterpenoids with an unprecedented 6/6/6/6/6/5/6/6/6 nonacyclic framework, pterolobirins A and B (1 and 2), were isolated from the fruits… Continue reading Pterolobirins A and B, Oxygen-Bridged Cassane Diterpenoid Dimers from the Fruits of Pterolobium macropterum
2020 / Current Research in Structural Biology
The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity… Continue reading Integrative Structural Biology Studies of HIV-1 Reverse Transcriptase Binding to a High-Affinity DNA Aptamer
2020 / Langmuir
Encapsulation of charged proteins into complex coacervate core micelles (C3Ms) can be accomplished by mixing them with oppositely charged diblock… Continue reading Balancing Enzyme Encapsulation Efficiency and Stability in Complex Coacervate Core Micelles
2020 / Materials Today Communications
In this study, a novel bio-inspired method was used to synthesize calcium carbonate nanoparticles (CaCO3 NPs) using gelatin as a template… Continue reading Zein coated calcium carbonate nanoparticles for the targeted controlled release of model antibiotic and nutrient across the intestine
2020 / Biomacromolecules
A series of cationic polypeptide imidazolium conjugates were prepared by ring-opening polymerization (ROP) of γ-4-(3-chloropropoxycarbonyl)benzyl-L- glutamic acid-based N-carboxyanhydride (CPBLG-NCA) initiated by… Continue reading Synthesis and Properties of Mono- or Diamine-Initiated Imidazolium-Based Cationic Polypeptides
2020 / International Journal of Biological Macromolecules
The drugs-protein binding study is of growing importance for drug-repurposing against amyloidosis. In this work, we study the binding of… Continue reading The reorganization of conformations, stability and aggregation of serum albumin isomers through the interaction of glycopeptide antibiotic teicoplanin: A thermodynamic and spectroscopy study
2020 / JACS
Incorporating chiral organic molecules into organic/inorganic hybrid 2D metal-halide perovskites results in a novel family of chiral hybrid semiconductors with… Continue reading Highly Distorted Chiral Two-Dimensional Tin Iodide Perovskites for Spin Polarized Charge Transport
2020 / ACS Chemical Neuroscience
Inhibition of β-amyloid peptide (Αβ) aggregation in Alzheimer’s disease (AD) is among the therapeutic approaches against AD which still attracts… Continue reading Novel Isatin Thiosemicarbazone Derivatives as Potent Inhibitors of β-Amyloid Peptide Aggregation and Toxicity
2020 / Aquaculture
To increase the value of bester sturgeon (a hybrid of Huso huso × Acipenser ruthenus) and promote development of the sturgeon aquaculture industry,… Continue reading Feasibility of collagens obtained from bester sturgeon Huso huso × Acipenser ruthenus for industrial use
2020 / RSC Advances
Osteoporosis is a metabolic bone disease that is characterized by low bone mass and micro-architectural deterioration of bones. The mechanism… Continue reading Synthesis and anti-osteoporosis activity of novel Teriparatide glycosylation derivatives
2020 / International Journal of Biological Macromolecules
Lectins are a specialized group of proteins with immense biological properties and applications. This study describes the purification and characterization… Continue reading A Glucose binding lectin from Leucaena leucocephala seeds and its mitogenic activity against human lymphocytes
2020 / Tetrahedron Letters
Three new alkaloids, 21-epi-taichunamide D (1) and (±)-versicalin A ((±)-6), along with four known analogues (2–5) were isolated from the… Continue reading 21-Epi-taichunamide D and (±)-versicaline A, three unusual alkaloids from the endophytic Aspergillus versicolor F210
2020 / ACS Omega
Curcumin is an important molecule with a plethora of pharmacological activities and therapeutic potentials. Despite its efficacy, it remained a… Continue reading Multitargeting Antibacterial Activity of a Synthesized Mn2+ Complex of Curcumin on Gram-Positive and Gram-Negative Bacterial Strains
2020 / European Journal of Pharmaceutical Sciences
With the increment of drug-resistant bacteria and the slow development of novel antibiotics, antimicrobial peptides have gained increasing attention as… Continue reading Effect of N-methylated and fatty acid conjugation on analogs of antimicrobial peptide Anoplin
2020 / Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Guanylate cyclase activating protein 1 (GCAP1) is a neuronal calcium sensor (NCS) involved in the early biochemical steps underlying the… Continue reading Missense mutations affecting Ca2+-coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties
