Circular Dichroism Archives

Genetic recombination of poly(l-lysine) functionalized apoferritin nanocages that resemble viral capsid nanometer-sized platforms for gene therapy

2020 / Biomaterials Science

Currently, bioengineered apoferritin nanocages with flexible protein shells and functionalized modifications have become an attractive approach for efficient anti-tumor therapy.… Continue reading Genetic recombination of poly(l-lysine) functionalized apoferritin nanocages that resemble viral capsid nanometer-sized platforms for gene therapy

The Stability Maintenance of Protein Drugs in Organic Coatings Based on Nanogels

2020 / Pharmaceutics

Protein drugs are often loaded on scaffolds with organic coatings to realize a spatiotemporal controlled release. The stability or activity… Continue reading The Stability Maintenance of Protein Drugs in Organic Coatings Based on Nanogels

Mechanism of enhancing foaming properties of egg white by super critical carbon dioxide treatment

2020 / Food Chemistry

The effect of supercritical carbon dioxide (SCCD) treatment at varying processing time (30–90 min) on foaming and structure properties of egg… Continue reading Mechanism of enhancing foaming properties of egg white by super critical carbon dioxide treatment

Mechanistic explanation of structural and functional changes induced by methionine mutation in G-CSF protein

2020 / Current Research in Biotechnology

Potency of a biotherapeutic is influenced by its binding affinity to the designated receptor., This study examines how substitution of… Continue reading Mechanistic explanation of structural and functional changes induced by methionine mutation in G-CSF protein

Monarubins A–C from the Marine Shellfish-Associated Fungus Monascus ruber BB5

2020 / Marine Drugs

Three new compounds, monarubins A–C (1, 6 and 13), together with ten known compounds, including four alkaloids (2–5), two isocoumarins (7 and 8) and four… Continue reading Monarubins A–C from the Marine Shellfish-Associated Fungus Monascus ruber BB5

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

2020 / Biomacromolecules

Alzheimer’s disease is associated with the deposition of the amyloid-β peptide (Aβ) into extracellular senile plaques in the brain. In… Continue reading Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

Genetically Expanded Reactive-Oxygen-Tolerant Alcohol Dehydrogenase II

2020 / ACS Catalysis

Herein, we report the site-specific incorporation of l-3,4-dihydroxyphenylalanine as a promising method to engineer an oxygen-tolerant alcohol dehydrogenase II. The engineered… Continue reading Genetically Expanded Reactive-Oxygen-Tolerant Alcohol Dehydrogenase II

Meiotic chromosome synapsis depends on multivalent SYCE1-SIX6OS1 interactions that are disrupted in cases of human infertility

2020 / bioRxiv

Meiotic reductional division is dependent on the synaptonemal complex (SC), a supramolecular protein assembly that mediates homologous chromosomes synapsis and… Continue reading Meiotic chromosome synapsis depends on multivalent SYCE1-SIX6OS1 interactions that are disrupted in cases of human infertility

Privileged Scaffold Chalcone: Synthesis, Characterization and Its Mechanistic Interaction Studies with BSA Employing Spectroscopic and Chemoinformatics Approaches

2020 / ACS Omega

Chalcone, a privileged structure, is considered as an effective template in the field of medicinal chemistry for potent drug discovery.… Continue reading Privileged Scaffold Chalcone: Synthesis, Characterization and Its Mechanistic Interaction Studies with BSA Employing Spectroscopic and Chemoinformatics Approaches

Antifungal Norditerpene Oidiolactones from the Fungus Oidiodendron truncatum, a Potential Biocontrol Agent for White-Nose Syndrome in Bats

2020 / Journal of Natural Products

White-nose syndrome (WNS) is a devastating disease of hibernating bats caused by the fungus Pseudogymnoascus destructans. We obtained 383 fungal and… Continue reading Antifungal Norditerpene Oidiolactones from the Fungus Oidiodendron truncatum, a Potential Biocontrol Agent for White-Nose Syndrome in Bats

Preparative Isolation of Piceatannol Derivatives from Passion Fruit (Passiflora edulis) Seeds by High-Speed Countercurrent Chromatography Combined with High-Performance Liquid Chromatography and Screening for α-Glucosidase Inhibitory Activities

2020 / Journal of Agriculture and Food Chemistry

Passiflora edulis Sims (passion fruit) seeds are often discarded as byproducts during juice processing. In fact, the seeds are of considerable… Continue reading Preparative Isolation of Piceatannol Derivatives from Passion Fruit (Passiflora edulis) Seeds by High-Speed Countercurrent Chromatography Combined with High-Performance Liquid Chromatography and Screening for α-Glucosidase Inhibitory Activities

Absolute Configuration and Corrected NMR Assignment of 17-Hydroxycyclooctatin, a Fused 5–8–5 Tricyclic Diterpene

2020 / Journal of Natural Products

The absolute configuration and corrected NMR assignment of 17-hydroxycyclooctatin isolated from Streptomyces sp. M56 recovered from a nest of South African Macrotermes natalensis termites… Continue reading Absolute Configuration and Corrected NMR Assignment of 17-Hydroxycyclooctatin, a Fused 5–8–5 Tricyclic Diterpene

Isolation and characterization of cytotoxic withanolides from the calyx of Physalis alkekengi L. var franchetii

2020 / Bioorganic Chemistry

Phytochemical investigation into the calyx of Physalis alkekengi L. var franchetii (Mast) Makino resulted in the isolation of ten cytotoxic withanolides, including five new… Continue reading Isolation and characterization of cytotoxic withanolides from the calyx of Physalis alkekengi L. var franchetii

Near-infrared-driven Au-decorated polymer-metal protein microfibers with bacterial filtration ability for use in photothermal sterilization

2020 / Chemical Engineering Journal

The use of protein nanostructures can be widely applied in medical devices and biomaterials. However, the synthesis of photothermic bovine… Continue reading Near-infrared-driven Au-decorated polymer-metal protein microfibers with bacterial filtration ability for use in photothermal sterilization

Cytotoxic alkaloids from the marine shellfish-associated fungus Aspergillus sp. XBB-4 induced by an amino acid-directed strategy

2020 / RSC Advances

Eight different culture media were used to culture shellfish Panopea abbreviate associated fungus Aspergillus sp. XBB-4. In a glucose-peptone-yeast (GPY) culture medium supplied with… Continue reading Cytotoxic alkaloids from the marine shellfish-associated fungus Aspergillus sp. XBB-4 induced by an amino acid-directed strategy

Novel diindoloazepinone derivatives as DNA minor groove binding agents with selective topoisomerase I inhibition: Design, synthesis, biological evaluation and docking studies

2020 / Bioorganic Chemistry

We present here-in the molecular design and chemical synthesis of a novel series of diindoloazepinone derivatives as DNA minor groove… Continue reading Novel diindoloazepinone derivatives as DNA minor groove binding agents with selective topoisomerase I inhibition: Design, synthesis, biological evaluation and docking studies

“Bottom-Up” Strategy for the Identification of Novel Soybean Peptides with Angiotensin-Converting Enzyme Inhibitory Activity

2020 / Journal of Agriculture and Food Chemistry

IAVPTGVA (Soy1) and LPYP are two soybean peptides, which display a multifunctional behavior, showing in vitro hypocholesterolemic and hypoglycemic activities.… Continue reading “Bottom-Up” Strategy for the Identification of Novel Soybean Peptides with Angiotensin-Converting Enzyme Inhibitory Activity

Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA

2020 / Journal of Medicinal Chemistry

αO-conotoxin GeXIVA from Conus generalis is a potent antagonist of the α9α10 nAChR and analgesic in animal models of pain. This peptide… Continue reading Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA

Destabilisation of the c-kit1 G-quadruplex structure by N6-methyladenosine modification

2020 / Biochemical and Biophysical Research Communications

N6-methyladenine (m6dA) has been recently discovered in eukaryotic genomic DNA. However, there have been few reports on its biological roles.… Continue reading Destabilisation of the c-kit1 G-quadruplex structure by N6-methyladenosine modification

Glyoxal modification mediates conformational alterations in silk fibroin: Induction of fibrillation with amyloidal features

2020 / Journal of Biosciences

Silkworm silk protein fibroin is widely exploited to develop novel silk-based biomaterials due to its stable β-sheet structure, providing high… Continue reading Glyoxal modification mediates conformational alterations in silk fibroin: Induction of fibrillation with amyloidal features

JASCO

KnowledgeBase Articles

Year

Technique

Industry