l-Phenylalanine Alters the Privileged Secondary Metabolite Production in the Marine-Derived Fungus Trichoderma erinaceum F1-1

2019 / Journal of Natural Products

The effects of a single-amino-acid culture strategy on secondary metabolite production in the marine-derived fungus Trichoderma erinaceum F1-1 were investigated by culturing… Continue reading l-Phenylalanine Alters the Privileged Secondary Metabolite Production in the Marine-Derived Fungus Trichoderma erinaceum F1-1

Leah Pandiscia, PhD

MYH9 Key Amino Acid Residues Identified by the Anti-Idiotypic Antibody to Porcine Reproductive and Respiratory Syndrome Virus Glycoprotein 5 Involve in the Virus Internalization by Porcine Alveolar Macrophages

2020 / Viruses

MYH9 has been identified as an indispensable cellular protein for porcine reproductive and respiratory syndrome virus (PRRSV) entry into permissive… Continue reading MYH9 Key Amino Acid Residues Identified by the Anti-Idiotypic Antibody to Porcine Reproductive and Respiratory Syndrome Virus Glycoprotein 5 Involve in the Virus Internalization by Porcine Alveolar Macrophages

Leah Pandiscia, PhD

Improved performances of catalytic G-quadruplexes (G4-DNAzymes) via the chemical modifications of the DNA backbone to provide G-quadruplexes with double 3′-external G-quartets

2019 / International Journal of Biological Macromolecules

Here we report on the design of a new catalytic G-quadruplex-DNA system (G4-DNAzyme) based on the modification of the DNA… Continue reading Improved performances of catalytic G-quadruplexes (G4-DNAzymes) via the chemical modifications of the DNA backbone to provide G-quadruplexes with double 3′-external G-quartets

Leah Pandiscia, PhD

Comparative analysis of the chemical treatments used in keratin extraction from red sheep’s hair and the cell viability evaluations of this keratin for tissue engineering applications

2019 / Process Biochemistry

Hair waste is one of the solid substances rejected by the leather industry. This waste finds its way into the… Continue reading Comparative analysis of the chemical treatments used in keratin extraction from red sheep’s hair and the cell viability evaluations of this keratin for tissue engineering applications

Leah Pandiscia, PhD

Biophysical characterization of oligomerization and fibrillization of the G131V pathogenic mutant of human prion protein

2019 / Acta Biochimica et Biophysica Sinica

The pathogenesis of fatal neurodegenerative prion diseases is closely associated with the conversion of α-helix-rich cellular prion protein into β-sheet-rich… Continue reading Biophysical characterization of oligomerization and fibrillization of the G131V pathogenic mutant of human prion protein

Leah Pandiscia, PhD

Truncated domains of human serum albumin improves the binding efficiency of uremic toxins: A surface plasmon resonance and computational approach

2019 / International Journal of Biological Macromolecules

Albumin binding is the major cause for the toxicity of protein bound uremic toxins (PBUTs) in uremic patients. Albumin binding… Continue reading Truncated domains of human serum albumin improves the binding efficiency of uremic toxins: A surface plasmon resonance and computational approach

Leah Pandiscia, PhD

Mutation studies and structure-based identification of potential inhibitor molecules against periplasmic amino acid binding protein of Candidatus Liberibacter asiaticus (CLasTcyA)

2019 / International Journal of Biological Macromolecules

Earlier reported crystal structure of CLasTcyA revealed unique features like relatively a larger substrate binding pocket, an extended C-terminal loop… Continue reading Mutation studies and structure-based identification of potential inhibitor molecules against periplasmic amino acid binding protein of Candidatus Liberibacter asiaticus (CLasTcyA)

Leah Pandiscia, PhD

Complex formation processes and metal ion catalyzed oxidation of model peptides related to the metal binding site of the human prion protein

2020 / Journal of Inorganic Biochemistry

Interaction of copper(II) and nickel(II) ions with the Ac-PHAAAGTHSMKHM-NH2 tridecapeptide containing the His85, His96 and His111 binding sites of human prion… Continue reading Complex formation processes and metal ion catalyzed oxidation of model peptides related to the metal binding site of the human prion protein

Leah Pandiscia, PhD

Phenolic glycosides from Magnolia figo

2019 / Phytochemistry Letters

Three new phenolic glycosides were isolated from the leaves and twigs of Magnolia figo, and identitified to be 3,4-dihydroxy-β-phenylethoxyl-O-[β-D-glucopyranosyl-(1″→2′)-α-L-rhamnopyranosyl-(1′”→3′)-(4′-O-trans-caffeoyl)-β-D-glucopyranosyl-(1′””→6′)]-β-D-glucopyranoside (champikhaekoside, 8), 4-hydroxybenzyl O-β-D-apiofuranosyl-(1″→2′)-[β-D-glucopyranosyl-(1′”→3′)]-β-D-glucopyranoside… Continue reading Phenolic glycosides from Magnolia figo

Leah Pandiscia, PhD