Leah Pandiscia, PhD
March 24, 2020
Apohemoglobin (apoHb) is a dimeric globular protein with two vacant heme‐binding pockets that can bind heme or other hydrophobic ligands.… Continue reading Novel manufacturing method for producing apohemoglobin and its biophysical properties
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Sulfur is an essential nutrient that can be converted into utilizable metabolic forms to produce sulfur-containing metabolites in plant. Adenosine… Continue reading C-Terminal Redox Domain of Arabidopsis APR1 Is a Non-Canonical Thioredoxin Domain with Glutaredoxin Function
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Polymorphism in the alcohol dehydrogenase (ADH) protein of Drosophila melanogaster, like genetic variation in many other enzymes, has long been hypothesized… Continue reading Fitness effects but no temperature-mediated balancing selection at the polymorphic Adh gene of Drosophila melanogaster
Leah Pandiscia, PhD
March 24, 2020
While biologic drugs such as proteins, peptides, or nucleic acids have shown promise in the treatment of neurodegenerative diseases, the… Continue reading Targeting Ligands Deliver Model Drug Cargo into the Central Nervous System along Autonomic Neurons
Leah Pandiscia, PhD
March 24, 2020
Ligand-switch reactions at the heme iron are common in biological systems, but their mechanisms and the features of the polypeptide… Continue reading A Heme Propionate Staples the Structure of Cytochrome c for Methionine Ligation to the Heme Iron
Leah Pandiscia, PhD
March 24, 2020
An aptamer-amphiphile was designed that binds to β-lactoglobulin (β-LG), a major allergen from cow’s milk. For this work, a 23-nucleotide… Continue reading Design of an Aptamer-Amphiphile for the Detection of β-Lactoglobulin on a Liquid Crystal Interface
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Peptide amphiphile micelles (PAMs) are a powerful platform technology for improving the delivery of therapeutic and prophylactic peptides. While previous… Continue reading Therapeutic peptide delivery via aptamer-displaying, disulfide-linked peptide amphiphile micelles
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Metal dyshomeostasis is central to a number of disorders that result from, inter alia, oxidative stress, protein misfolding, and cholesterol… Continue reading Synthesis and Study of Multifunctional Cyclodextrin–Deferasirox Hybrids
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
June 29, 2020
Phosphorylation is one of the main regulators of cellular signaling typically occurring in flexible parts of folded proteins and in… Continue reading Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
The current study investigated the binding of BSA and piperacillin at multifarious concentrations (1–128 μM) along with four different temperatures. To… Continue reading Kinetic and thermodynamic insights into interaction of albumin with piperacillin: Spectroscopic and molecular modeling approaches
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020