2022 / Nature communications
The transfer of the concept of chirality from molecules to synthesized nanomaterials has attracted attention amongst multidisciplinary teams. Here we… Continue reading Chiral nanocrystals grown from MoS2 nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs
2022 / Nature communications
Various 4-alkylphenols can be easily obtained through reductive catalytic fractionation of lignocellulosic biomass. Selective dehydrogenation of 4-n-propylguaiacol results in the… Continue reading Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound
2022 / Nature communications
Many bacteria in nature exist in multicellular communities termed biofilms, where cells are embedded in an extracellular matrix that provides… Continue reading Donor-strand exchange drives assembly of the TasA scaffold in Bacillus subtilis biofilms
2022 / Nature communications
TRIM5α is an E3 ubiquitin ligase of the TRIM family that binds to the capsids of primate immunodeficiency viruses and… Continue reading Structural and functional asymmetry of RING trimerization controls priming and extension events in TRIM5α autoubiquitylation
2022 / Nature communications
Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipocyte differentiation, and mutations that interfere with its function cause… Continue reading PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation
2022 / Nature communications
The binding of intrinsically disordered proteins to globular ones can require the folding of motifs into α-helices. These interactions offer… Continue reading A glutamine-based single α-helix scaffold to target globular proteins
2022 / Scientific Reports
Crossing the cellular membrane is one of the main barriers during drug discovery; many potential drugs are rejected for their… Continue reading Insights into the equilibrium structure and translocation mechanism of TP1, a spontaneous membrane-translocating peptide
2022 / Communications Biology
Antibodies against the carboxy-terminal section of the membrane-proximal external region (C-MPER) of the HIV-1 envelope glycoprotein (Env) are considered as… Continue reading Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope
2022 / Nature nanotechnology
Fabricating microscale helical structures from small molecules remains challenging due to the disfavoured torsion energy of twisted architectures and elusory… Continue reading Hierarchically self-assembled homochiral helical microtoroids
2022 / Nature communications
Mutual interference between surface ligands on multifunctional nanoparticles remains a significant obstacle to achieving optimal drug-delivery efficacy. Here, we develop… Continue reading Ligand-switchable nanoparticles resembling viral surface for sequential drug delivery and improved oral insulin therapy
2022 / Scientific Reports
Functional peptides, which are composed of proteinogenic natural amino acids, are expected to be used as biomaterials with minimal environmental… Continue reading Development of truncated elastin-like peptide analogues with improved temperature-response and self-assembling properties
2022 / Nature communications
The abundance of plasma membrane-resident receptors and transporters has to be tightly regulated by ubiquitin-mediated endosomal degradation for the proper… Continue reading Lipid-mediated activation of plasma membrane-localized deubiquitylating enzymes modulate endosomal trafficking
2022 / Nature communications
Stability of eukaryotic mRNAs is associated with their codon, amino acid, and GC content. Yet, coding sequence motifs that predictably… Continue reading A nascent peptide code for translational control of mRNA stability in human cells
2022 / Nature communications
DNA:DNA:RNA triplexes that are formed through Hoogsteen base-pairing of the RNA in the major groove of the DNA duplex have… Continue reading HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex
2022 / Communications Biology
Coronavirus infections are a world-wide threat to human health. A promising strategy to develop a broadly active antiviral is the… Continue reading Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants
2022 / Cell research
The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike (S) protein are weakening the efficacy of… Continue reading A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein
2022 / ChemPhysChem
The synthesis and characterization of diketopyrrolopyrroles and perylenemonoimidodiesters linked to a substituted benzoic acid in the ortho, meta, and para… Continue reading Disentangling Excimer Emission from Chiral Induction in Nanoscale Helical Silica Scaffolds Bearing Achiral Chromophores
2022 / Nature communications
The exquisite specificity between a sensor kinase and its cognate response regulator ensures faithful partner selectivity within two-component pairs concurrently… Continue reading Promiscuity of response regulators for thioredoxin steers bacterial virulence
2022 / Communications Materials
The extracellular matrix (ECM) is a natural scaffold of cells in the body. It has a complex structure comprising various… Continue reading Extracellular matrix-inspired hydrogel of hyaluronan and gelatin crosslinked via a Link module with a transglutaminase reactive sequence
2022 / Scientific Reports
Human mitochondrial chaperonin mHsp60 is broadly associated with various human health conditions and the V72I mutation in mHsp60 causes a… Continue reading Hereditary spastic paraplegia SPG13 mutation increases structural stability and ATPase activity of human mitochondrial chaperonin
