Three binuclear Schiff base copper(II) complexes: [Cu2(HL1)2(CH3OH)(NO3)]·NO3 (1), [Cu2(HL2)2(CH3OH)2]·2NO3 (2), and [Cu2(HL3)2(C2H5OH)2]·2NO3 (3) [HL1 = (E)-N′-(5-fluoro-2-hydroxybenzylidene)benzohydrazide, HL2 = (E)-N′-(5-chloro-2-hydroxybenzylidene)benzohydrazide, and HL3 = (E)-N′-(5-bromo-2-hydroxybenzylidene)benzohydrazide], were synthesized and characterized employing various… Continue reading Binuclear Schiff base copper(II) complexes: Syntheses, crystal structures, HSA interaction and anti-cancer properties
Leah Pandiscia, PhD
March 24, 2020
Laccases are multi-copper oxidase enzymes having widespread applications in various biotechnological fields. However, low stability of free enzymes restricts their… Continue reading Enhanced Thermostability and Anticancer Activity in Breast Cancer Cells of Laccase Immobilized on Pluronic-Stabilized Nanoparticles
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Protein therapy gained a reputation of the most direct and safe approach for treating various diseases, yet biodegradation and loss… Continue reading Bioactivity of catalase loaded into vaterite CaCO3 crystals via adsorption and co-synthesis
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
The synthesis of a novel modified nucleoside phosphoramidite, Acrylamide-dT-CE phosphoramidite, obtained in three steps from commercially available starting materials, is… Continue reading Acrylamide-dT: a polymerisable nucleoside for DNA incorporation
Leah Pandiscia, PhD
March 24, 2020
Isoxazole-triazole conjugates (8a-q) were synthesized using click chemistry approach and their biological activities were explored to develop novel antibacterial agents. In vitro antibacterial… Continue reading Biofilm inhibition and DNA binding studies of isoxazole-triazole conjugates in the development of effective anti-bacterial agents
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Racemic mixtures frequently display properties that are different from those associated with their enantiopure counterparts, and are often characterized by… Continue reading New insights into differential aggregation of enantiomerically pure and racemic Aβ40 systems
Leah Pandiscia, PhD
March 24, 2020
As a homo‐oligomeric protein, the disassembly of Escherichia coli RbsD decamer produces a urea‐unfolded oligomeric intermediate structure, as the dissociation speed of the… Continue reading The role of Lys2–Cl−–Lys2 salt linkages in oligomeric intermediates of RbsD protein in Escherichia coli
Leah Pandiscia, PhD
March 24, 2020
Graft copolymers consisting of two different zwitterionic blocks were synthesized via reversible addition fragmentation chain transfer polymerization. These polymers showed… Continue reading Dual Thermo- and pH-Responsive Behavior of Double Zwitterionic Graft Copolymers for Suppression of Protein Aggregation and Protein Release
Leah Pandiscia, PhD
March 24, 2020
Lysozyme (LYZ) is a model protein frequently employed to study interaction with drugs and to understand the crystallization process of… Continue reading Investigation of complexation of amlodipine with lysozyme and its effect on lysozyme crystal growth
Leah Pandiscia, PhD
March 24, 2020
The intensive use of water containing dyes by the textile industry, and consequently the contamination of soils and water, represents… Continue reading Improvements in the enzymatic degradation of textile dyes using ionic-liquid-based surfactants
Leah Pandiscia, PhD
March 24, 2020
α-Synuclein misfolding results in the accumulation of amyloid fibrils in Parkinson’s disease. Missense protein mutations (e.g. A53T) have been linked… Continue reading Synaptic vesicle mimics affect the aggregation of wild-type and A53T α-synuclein variants differently albeit similar membrane affinity
Leah Pandiscia, PhD
March 24, 2020
Fluorescence and circular dichroism spectroscopic techniques and molecular docking were used to study binding of azelastine with human serum albumin… Continue reading Multi-spectroscopic and molecular docking technique study of the azelastine interaction with human serum albumin
Leah Pandiscia, PhD
March 24, 2020
Two-dimensional sheet-like supramolecules have attracted much attention from the viewpoints of their potential application as functional (nano)materials due to unique… Continue reading Bioinspired supramolecular nanosheets of zinc chlorophyll assemblies
Leah Pandiscia, PhD
March 24, 2020
HIV-1 Gag is a highly flexible multidomain protein that forms the protein lattice of the immature HIV-1 virion. In vitro, it… Continue reading Nucleic acid-induced dimerization of HIV-1 Gag protein
Leah Pandiscia, PhD
March 24, 2020
DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be… Continue reading Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity
Leah Pandiscia, PhD
March 24, 2020
Dietary phenolic compounds display strong antioxidant capabilities but face limited practical applications as a result of their poor biocompatibility (high… Continue reading Improving Antioxidant Activity of β-Lactoglobulin by Nature-Inspired Conjugation with Gentisic Acid
Leah Pandiscia, PhD
June 29, 2020
In our continuing search for novel natural products with antiplasmodial activity, an extract of Aniba citrifolia was found to have good activity,… Continue reading Anibamine and Its Analogues: Potent Antiplasmodial Agents from Aniba citrifolia
Leah Pandiscia, PhD
March 24, 2020
