2022 / Chirality
Nanocolloids that are cumulatively referred to as nanocarbons, attracted significant attention during the last decade because of facile synthesis methods,… Continue reading Hydrothermal synthesis of chiral carbon dots
2022 / Chemistry & Biodiversity
Chemical investigation of Retama sphaerocarpa collected in Algeria resulted in the isolation of two megastigmane glucosides, compounds 1 and 2,… Continue reading First Occurrence of Megastigmane Glucosides in a Plant of Retama Genus
2022 / Biotechnology and Applied Biochemistry
Chinese Hamster Ovary cells (CHO) have become the most common workhorse for the commercial production of therapeutic proteins, as well… Continue reading Optimized rapid production of recombinant secreted proteins in CHO cells grown in suspension: The case of RBD
2022 / Chirality
Chiral carbon nanoparticles (CNPs) represent a rapidly evolving area of research for optical and biomedical technologies. Similar to small molecules,… Continue reading Chiral chromatography and surface chirality of carbon nanoparticles
2022 / Nature Communications
Dialysis-related amyloidosis (DRA), a serious complication among long-term hemodialysis patients, is caused by amyloid fibrils of β2-microglobulin (β2m). Although high… Continue reading Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis
2022 / Cell Death & Disease
Calcium concentration must be finely tuned in all eukaryotic cells to ensure the correct performance of its signalling function. Neuronal… Continue reading The ataxia-linked E1081Q mutation affects the sub-plasma membrane Ca2+-microdomains by tuning PMCA3 activity
2022 / Scientific Reports
Humans and Acanthamoeba polyphaga mimivirus share numerous homologous genes, including collagens and collagen-modifying enzymes. To explore this homology, we performed… Continue reading Comparative genomic and biochemical analyses identify a collagen galactosylhydroxylysyl glucosyltransferase from Acanthamoeba polyphaga mimivirus
2022 / Nature Communications
KRAS is one of the most highly mutated oncoproteins, which is overexpressed in various human cancers and implicated in poor… Continue reading Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine
2022 / Nature Communications
The development of mechanochemistry substantially expands the traditional synthetic realm at the molecular level. Here, we extend the concept of… Continue reading Chiral superstructures of inorganic nanorods by macroscopic mechanical grinding
2022 / Nature Communications
Dynamic regulation of nucleic acid hybridization is fundamental for switchable nanostructures and controllable functionalities of nucleic acids in both material… Continue reading Controllable DNA hybridization by host–guest complexation-mediated ligand invasion
2022 / Nature Communications
Antibodies, and antibody derivatives such as nanobodies, contain immunoglobulin-like (Ig) β-sandwich scaffolds which anchor the hypervariable antigen-binding loops and constitute… Continue reading De novo design of immunoglobulin-like domains
2022 / Communications Biology
Eukaryotic Cu, Zn-superoxide dismutase (SOD1) is primarily responsible for cytotoxic filament formation in amyotrophic lateral sclerosis (ALS) neurons. Two cysteine… Continue reading Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation
2022 / Scientific Reports
Phosphoglycerate kinase has been a model for the stability, folding cooperativity and catalysis of a two-domain protein. The human isoform… Continue reading Loss of stability and unfolding cooperativity in hPGK1 upon gradual structural perturbation of its N-terminal domain hydrophobic core
2022 / Molecular Phychiatry
St. John’s wort is an herb, long used in folk medicine for the treatment of mild depression. Its antidepressant constituent,… Continue reading Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs
2022 / Communications Chemistry
Since imine reductases (IREDs) were reported to catalyze the reductive amination reactions, they became particularly attractive for producing chiral amines.… Continue reading Actinomycetes-derived imine reductases with a preference towards bulky amine substrates
2022 / SAGE Journals Applied Spectroscopy OnlineFirst
Circular dichroism (CD) spectroscopy is a widely used technique for assessing the higher-order structure (HOS) of biopharmaceuticals, including antibody drugs.… Continue reading Performance Comparison of Spectral Distance Calculation Methods
2021 / Evolutionary Biology
We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although… Continue reading Reduced purine biosynthesis in humans after their divergence from Neandertals
2022 / Scientific Reports
Dynein light chain LC8 is a small dimeric hub protein that recognizes its partners through short linear motifs and is… Continue reading The interaction between LC8 and LCA5 reveals a novel oligomerization function of LC8 in the ciliary-centrosome system
2022 / FEBS openbio
Hydroxymethylbilane synthase (HMBS) is the third enzyme involved in haem biosynthesis, in which it catalyses the formation of tetrapyrrole 1-hydroxymethylbilane… Continue reading Characterisation of a common hotspot variant in acute intermittent porphyria sheds light on the mechanism of hydroxymethylbilane synthase function
2022 / Biotechnology and Bioengineering
Cell-free heme, which was previously shown to have adverse effects on the innate immune system, does not induce inflammation when… Continue reading Scalable manufacturing platform for the production of PEGylated heme albumin
