• Year

  • Technique

  • Industry

Improving Cancer Detection and Treatment by pH-Sensitive Peptide Nanoparticle Drug Delivery Platform: Pharmacokinetics, Toxicity, and Immunogenicity Profile

2021 / ADVANCED NANOBIOMED RESEARCH

It was previously reported that a nanoparticle made of ultra pH-sensitive peptides (pH-NP) undergoes self-dissolution in moderately acidic (pH ≤ 6.9) condition… Continue reading Improving Cancer Detection and Treatment by pH-Sensitive Peptide Nanoparticle Drug Delivery Platform: Pharmacokinetics, Toxicity, and Immunogenicity Profile

Carlos Morillo January 5, 2022

From Quinoline to Quinazoline-Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search

2021 / ChemMedChem

Antibiotic resistance breakers, such as efflux pump inhibitors (EPIs), represent a powerful alternative to the development of new antimicrobials. Recently,… Continue reading From Quinoline to Quinazoline-Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search

Carlos Morillo January 5, 2022

A pair of chiral Cu(II)-Tb(III)-Fe(III) heterotrimetallic enantiomers: Structural, luminescent, and magnetic studies

2021 / Journal of the Chinese Chemical Society

One chiral heterotrimetallic compound, [Cu(H2O){(R,R)-valcy}Tb(CH3OH)2(H2O)(μ-CN)Fe(CN)5]·[Cu(H2O){(R,R)-valcy}Tb(CH3OH)1.5(H2O)1.5(μ-CN)Fe(CN)5]·7.85H2O·2CH3OH (1) (H2(R,R)-valcy = N,N′-bis(3-methoxysalicylidene)-1R,2R-1,2-diaminocyclohexane), has been prepared and structurally characterized by X-ray single-crystal diffraction. In… Continue reading A pair of chiral Cu(II)-Tb(III)-Fe(III) heterotrimetallic enantiomers: Structural, luminescent, and magnetic studies

Carlos Morillo January 5, 2022

Modulating the Enantiodiscrimination Features of Inherently Chiral Selectors by Molecular Design: A HPLC and Voltammetry Study Case with Atropisomeric 2,2’-Biindole-Based Monomers and Oligomer Films

2021 / Chemistry A European Journal

A family of inherently chiral electroactive selectors based on the 2,2’-biindole atropisomeric scaffold, of easy synthesis and modulable functional properties,… Continue reading Modulating the Enantiodiscrimination Features of Inherently Chiral Selectors by Molecular Design: A HPLC and Voltammetry Study Case with Atropisomeric 2,2’-Biindole-Based Monomers and Oligomer Films

Carlos Morillo January 5, 2022

Identification of a self-sufficient cytochrome P450 monooxygenase from Cupriavidus pinatubonensis JMP134 involved in 2-hydroxyphenylacetic acid catabolism, via homogentisate pathway

2021 / Microbial biotechnology

The self-sufficient cytochrome P450 RhF and its homologues belonging to the CYP116B subfamily have attracted considerable attention due to the… Continue reading Identification of a self-sufficient cytochrome P450 monooxygenase from Cupriavidus pinatubonensis JMP134 involved in 2-hydroxyphenylacetic acid catabolism, via homogentisate pathway

Carlos Morillo January 5, 2022

Characteristics of various fibrolytic isozyme activities in the rumen microbial communities of Japanese Black and Holstein Friesian cattle under different conditions

2021 / Animal Science Journal

Rumen microorganisms produce various fibrolytic enzymes and degrade lignocellulosic materials into nutrient sources for ruminants; therefore, the characterization of fibrolytic… Continue reading Characteristics of various fibrolytic isozyme activities in the rumen microbial communities of Japanese Black and Holstein Friesian cattle under different conditions

Carlos Morillo January 18, 2022

Identifying the essential nutritional requirements of the probiotic bacteria Bifidobacterium animalis and Bifidobacterium longum through genome-scale modeling

2021 / npj Systems Biology and Applications

Although bifidobacteria are widely used as probiotics, their metabolism and physiology remain to be explored in depth. In this work,… Continue reading Identifying the essential nutritional requirements of the probiotic bacteria Bifidobacterium animalis and Bifidobacterium longum through genome-scale modeling

Carlos Morillo December 16, 2021