KnowledgeBase Articles Archive

Characterization of a G-Quadruplex Structure in Pre-miRNA-1229 and in Its Alzheimer’s Disease-Associated Variant rs2291418: Implications for miRNA-1229 Maturation

2020 / International Journal of Molecular Sciences

Alzheimer’s disease (AD), the most common age-related neurodegenerative disease, is associated with various forms of cognitive and functional impairment that… Continue reading Characterization of a G-Quadruplex Structure in Pre-miRNA-1229 and in Its Alzheimer’s Disease-Associated Variant rs2291418: Implications for miRNA-1229 Maturation

De Novo Designed Protein-Interaction Modules for In-Cell Applications

2020 / ACS Synthetic Biology

Protein–protein interactions control a wide variety of natural biological processes. α-Helical coiled coils frequently mediate such protein–protein interactions. Due to… Continue reading De Novo Designed Protein-Interaction Modules for In-Cell Applications

Self-Assembly of Exendin-4-Derived Dual Peptide Agonists is Mediated by Acylation and Correlated to the Length of Conjugated Fatty Acyl Chains

2020 / molecular pharmaceutics

Dual glucagon-like peptide-1/glucagon receptor agonists have emerged as promising candidates for the treatment of diabetes and obesity. Issues of degradation… Continue reading Self-Assembly of Exendin-4-Derived Dual Peptide Agonists is Mediated by Acylation and Correlated to the Length of Conjugated Fatty Acyl Chains

The Cu(II) reductase RclA protects Escherichia coli against the combination of hypochlorous acid and intracellular copper

2020 / BioRxiv

Inflammatory bowel diseases (IBDs) are a growing health concern. Enterobacteria, including Escherichia coli, bloom to high levels in the gut during… Continue reading The Cu(II) reductase RclA protects Escherichia coli against the combination of hypochlorous acid and intracellular copper

Manipulation of the Coordination Geometry along the C4 Rotation Axis in a Dinuclear Tb3+ Triple‐Decker Complex via a Supramolecular Approach

2020 / Chemistry A European Journal

A supramolecular complex (1×C60) was prepared by assembling (C60‐Ih)[5,6]fullerene (C60) with the dinuclear Tb3+ triple‐decker complex [(TPP)Tb(Pc)Tb(TPP)] (1: Tb3+ =… Continue reading Manipulation of the Coordination Geometry along the C4 Rotation Axis in a Dinuclear Tb3+ Triple‐Decker Complex via a Supramolecular Approach

Room‐Temperature Phosphorescence‐active Boronate Particles: Characterization and Ratiometric Afterglow‐sensing Behavior by Surface Grafting of Rhodamine B

2020 / Chemistry An Asian Journal

We found that boronate particles (BP), as a self‐assembled system prepared by sequential dehydration of benzene‐1,4‐diboronic acid with pentaerythritol, showed… Continue reading Room‐Temperature Phosphorescence‐active Boronate Particles: Characterization and Ratiometric Afterglow‐sensing Behavior by Surface Grafting of Rhodamine B

Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors

2004 / Biochemical and Biophysical Research Communications

Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is a newly identified member of Family Coronaviridae. Coronavirus envelope spike protein S is a class I viral fusion… Continue reading Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors

Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region

2006 / FEBS Letters

The coronavirus nucleocapsid (N) protein binds viral RNA to form the ribonucleocapsid and regulate RNA synthesis. The interaction of N protein with viral RNA was investigated… Continue reading Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region

Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus

2004 / PNAS

The causative agent of a recent outbreak of an atypical pneumonia, known as severe acute respiratory syndrome (SARS), has been… Continue reading Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus

Identification and Characterization of the Putative Fusion Peptide of the Severe Acute Respiratory Syndrome-Associated Coronavirus Spike Protein

2005 / Journal of Virology

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a newly identified member of the family Coronaviridae and poses a serious public… Continue reading Identification and Characterization of the Putative Fusion Peptide of the Severe Acute Respiratory Syndrome-Associated Coronavirus Spike Protein

Differential Inhibitory Activities and Stabilisation of DNA Aptamers against the SARS Coronavirus Helicase

2008 / ChemBioChem

The helicase from severe acute respiratory syndrome coronavirus (SARS‐CoV) possesses NTPase, duplex RNA/DNA‐unwinding and RNA‐capping activities that are essential for… Continue reading Differential Inhibitory Activities and Stabilisation of DNA Aptamers against the SARS Coronavirus Helicase

Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein

2006 / Viral Research

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is the cause of an atypical pneumonia that affected Asia, North America and Europe… Continue reading Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein

Critical Assessment of Important Regions in the Subunit Association and Catalytic Action of the Severe Acute Respiratory Syndrome Coronavirus Main Protease

2005 / Journal of Biological Chemistry

The severe acute respiratory syndrome (SARS) coronavirus (CoV) main protease represents an attractive target for the development of novel anti-SARS… Continue reading Critical Assessment of Important Regions in the Subunit Association and Catalytic Action of the Severe Acute Respiratory Syndrome Coronavirus Main Protease

Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization

2004 / Journal of Biological Chemistry

Severe acute respiratory syndrome (SARS) coronavirus is a novel human coronavirus and is responsible for SARS infection. SARS coronavirus 3C-like… Continue reading Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization

Biochemical and immunological studies of nucleocapsid proteins of severe acute respiratory syndrome and 229E human coronaviruses

2005 / Proteomics

Severe acute respiratory syndrome (SARS) is a serious health threat and its early diagnosis is important for infection control and… Continue reading Biochemical and immunological studies of nucleocapsid proteins of severe acute respiratory syndrome and 229E human coronaviruses

Phosphorylation of the arginine/serine dipeptide‐rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization

2008 / The FEBS Journal

Coronavirus nucleocapsid protein is abundant in infected cells and participates in viral RNA replication and transcription. The central domain of… Continue reading Phosphorylation of the arginine/serine dipeptide‐rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization

The Aromatic Domain of the Coronavirus Class I Viral Fusion Protein Induces Membrane Permeabilization: Putative Role during Viral Entry

2004 / Biochemistry

Coronavirus (CoV) entry is mediated by the viral spike (S) glycoprotein, a class I viral fusion protein. During viral and… Continue reading The Aromatic Domain of the Coronavirus Class I Viral Fusion Protein Induces Membrane Permeabilization: Putative Role during Viral Entry

Quaternary Structure of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Main Protease

2004 / Biochemistry

SARS (severe acute respiratory syndrome) has been one of the most severe viral infectious diseases last year and still remains… Continue reading Quaternary Structure of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Main Protease

Hyperstable De Novo Protein with a Dimeric Bisecting Topology

2020 / ACS Synthetic Biology

Recently, we designed and assembled protein nanobuilding blocks (PN-Blocks) from an intermolecularly folded dimeric de novo protein called WA20. Using this dimeric… Continue reading Hyperstable De Novo Protein with a Dimeric Bisecting Topology

Regioselective Chemical Modification of Cysteine Residues on Protein Surfaces Focusing on Local Environment around the Conjugation Site

2020 / Bioconjugate Chemistry

For chemical modification of cysteines in a protein, the regioselectivity among cysteine residues on the protein surface is an issue… Continue reading Regioselective Chemical Modification of Cysteine Residues on Protein Surfaces Focusing on Local Environment around the Conjugation Site

JASCO

KnowledgeBase Articles

Year

Technique

Industry