Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a ligand of low-density lipoprotein receptor (LDLR) that promotes LDLR degradation in late endosomes/lysosomes.… Continue reading A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles
Leah Pandiscia, PhD
March 24, 2020
G-Quadruplex DNAs, formed by G-rich DNA sequences in human genes, are promising targets for design of cancer drugs. In this… Continue reading Synthesis, G-Quadruplex DNA binding and cytotoxic properties of naphthalimide substituted styryl dyes
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
The properties of non-canonical DNA structures, like G-quadruplexes and triplexes, change under cell-mimicking molecular crowding conditions relative to dilute aqueous… Continue reading Effect of Potassium Concentration on Triplex Stability under Molecular Crowding Conditions
Leah Pandiscia, PhD
March 24, 2020
DNA is polymorphic since, despite its ubiquitous presence as a double-stranded helix, it is able to fold into a plethora… Continue reading Harnessing intrinsic fluorescence for typing of secondary structures of DNA
Leah Pandiscia, PhD
March 24, 2020
Chirality—the property of an object wherein it is distinguishable from its mirror image—is of widespread interest in chemistry and biology1,2,3,4,5,6.… Continue reading Regioselective magnetization in semiconducting nanorods
Leah Pandiscia, PhD
March 24, 2020
Here, we report the formation of homochiral supramolecular thin film from achiral molecules, by using circularly polarized light (CPL) only… Continue reading Homochiral Supramolecular Thin Film from Self-Assembly of Achiral Triarylamine Molecules by Circularly Polarized Light
Leah Pandiscia, PhD
March 24, 2020
Insulin, a simple polypeptide hormone with huge biological importance, has long been known to self-assemble in vitro and form amyloid-like… Continue reading Molecular Details of a Salt Bridge and Its Role in Insulin Fibrillation by NMR and Raman Spectroscopic Analysis
Leah Pandiscia, PhD
March 24, 2020
The yeast fatty acid synthase (FAS) is a barrel-shaped 2.6 MDa complex. Upon barrel-formation, two multidomain subunits, each more than… Continue reading Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS)
Leah Pandiscia, PhD
March 24, 2020
Alzheimer’s disease (AD) is characterized by amyloid plaques and progressive cerebral atrophy. Here, we report FAM222A as a putative brain atrophy susceptibility… Continue reading FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Myoglobin is a heme-protein in the muscle of vertebrates with important functions in the oxygenation of tissues and as a… Continue reading Plant based production of myoglobin – a novel source of the muscle heme-protein
Leah Pandiscia, PhD
March 24, 2020
A cyclic tri-β-peptide cyclo(β-Ala-β-Ala-β-Lys) having diethylaminonaphthalimide at the β-Lys side chain (CP3Npi) self-assembled into a peptide nanotube in a solution… Continue reading Engineering pH-responsive switching of donor–π–acceptor chromophore alignments along a peptide nanotube scaffold
Leah Pandiscia, PhD
March 24, 2020
Clusters of superparamagnetic iron oxide nanoparticles (SPIONs) have been incorporated into the hydrophobic core of polyethylene glycol (PEG)-modified phospholipid micelles.… Continue reading Influence of Magnetic Micelles on Assembly and Deposition of Porphyrin J-Aggregates
Leah Pandiscia, PhD
March 24, 2020
Poly-aromatic peptide sequences are able to self-assemble into a variety of supramolecular aggregates such as fibers, hydrogels, and tree-like multi-branched… Continue reading Peptide-Based Soft Hydrogels Modified with Gadolinium Complexes as MRI Contrast Agents
Leah Pandiscia, PhD
March 24, 2020
Understanding nanoscale protein conformational changes at solid–liquid interfaces is critical for predicting how proteins will impact the performance of biomaterials… Continue reading Nanoscale Surface-Induced Unfolding of Single Fibronectin Is Restricted by Serum Albumin Crowding
Leah Pandiscia, PhD
March 24, 2020
The crystal structure of ZnZnuA from Escherichia coli reveals two metal binding sites. (i) The primary binding site, His143, is located close… Continue reading Metal Complexes of Two Specific Regions of ZnuA, a Periplasmic Zinc(II) Transporter from Escherichia coli
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020