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Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla

2020 / Phytochemistry

A phytochemical investigation on the MeOH extract of the twigs and needles of the endangered plant Picea brachytyla led to the isolation… Continue reading Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla

Fitness effects but no temperature-mediated balancing selection at the polymorphic Adh gene of Drosophila melanogaster

2019 / PNAS

Polymorphism in the alcohol dehydrogenase (ADH) protein of Drosophila melanogaster, like genetic variation in many other enzymes, has long been hypothesized… Continue reading Fitness effects but no temperature-mediated balancing selection at the polymorphic Adh gene of Drosophila melanogaster

Targeting Ligands Deliver Model Drug Cargo into the Central Nervous System along Autonomic Neurons

2019 / ACS Nano

While biologic drugs such as proteins, peptides, or nucleic acids have shown promise in the treatment of neurodegenerative diseases, the… Continue reading Targeting Ligands Deliver Model Drug Cargo into the Central Nervous System along Autonomic Neurons

A Heme Propionate Staples the Structure of Cytochrome c for Methionine Ligation to the Heme Iron

2019 / Inorganic Chemistry

Ligand-switch reactions at the heme iron are common in biological systems, but their mechanisms and the features of the polypeptide… Continue reading A Heme Propionate Staples the Structure of Cytochrome c for Methionine Ligation to the Heme Iron

Design of an Aptamer-Amphiphile for the Detection of β-Lactoglobulin on a Liquid Crystal Interface

2019 / Bioconjugate Chemistry

An aptamer-amphiphile was designed that binds to β-lactoglobulin (β-LG), a major allergen from cow’s milk. For this work, a 23-nucleotide… Continue reading Design of an Aptamer-Amphiphile for the Detection of β-Lactoglobulin on a Liquid Crystal Interface

Identification and Quantitation of Enantiomers by Capillary Electrophoresis and Circular Dichroism Independent of Single Enantiomer Standard

2019 / Analytical Chemistry

Identification and quantitation of enantiomers is a critical and challenging step in the process of chiral capillary electrophoresis (CE) analysis,… Continue reading Identification and Quantitation of Enantiomers by Capillary Electrophoresis and Circular Dichroism Independent of Single Enantiomer Standard

Deep-Red Light-up Signaling of Benzo[c,d]indole–Quinoline Monomethine Cyanine for Imaging of Nucleolar RNA in Living Cells and for Sequence-Selective RNA Analysis

2019 / Analytical Chemistry

RNA-binding small probes with deep-red emission are promising for RNA analysis in biological media without suffering from background fluorescence. Here… Continue reading Deep-Red Light-up Signaling of Benzo[c,d]indole–Quinoline Monomethine Cyanine for Imaging of Nucleolar RNA in Living Cells and for Sequence-Selective RNA Analysis

Therapeutic peptide delivery via aptamer-displaying, disulfide-linked peptide amphiphile micelles

2019 / Molecular Systems Design & Engineering

Peptide amphiphile micelles (PAMs) are a powerful platform technology for improving the delivery of therapeutic and prophylactic peptides. While previous… Continue reading Therapeutic peptide delivery via aptamer-displaying, disulfide-linked peptide amphiphile micelles

Fabrication and Characterization of Lutein-Loaded Nanoparticles Based on Zein and Sophorolipid: Enhancement of Water Solubility, Stability, and Bioaccessibility

2019 / Journal of Agricultural and Food Chemistry

Lutein is a hydrophobic carotenoid with various beneficial biological activities. Its use as a functional food, however, is currently limited… Continue reading Fabrication and Characterization of Lutein-Loaded Nanoparticles Based on Zein and Sophorolipid: Enhancement of Water Solubility, Stability, and Bioaccessibility

Synthesis and Study of Multifunctional Cyclodextrin–Deferasirox Hybrids

2019 / ChemMedChem

Metal dyshomeostasis is central to a number of disorders that result from, inter alia, oxidative stress, protein misfolding, and cholesterol… Continue reading Synthesis and Study of Multifunctional Cyclodextrin–Deferasirox Hybrids

Discovery of Neolignan Glycosides with Acetylcolinesterase Inhibitory Activity from Huangjinya Green Tea Guided by Ultra Performance Liquid Chromatography–Tandem Mass Spectrometry Data and Global Natural Product Social Molecular Networking

2019 / Journal of Agricultural and Food Chemistry

Global Natural Product Social feature-based networking was applied to follow the phytochemicals, including nine flavonoid glycosides, six catechins, and three… Continue reading Discovery of Neolignan Glycosides with Acetylcolinesterase Inhibitory Activity from Huangjinya Green Tea Guided by Ultra Performance Liquid Chromatography–Tandem Mass Spectrometry Data and Global Natural Product Social Molecular Networking

Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range

2019 / Journal of Biomolecular NMR

Phosphorylation is one of the main regulators of cellular signaling typically occurring in flexible parts of folded proteins and in… Continue reading Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range

A Systematic Study on the Double-Layered Photosensitizing Dye Structure on the Surface of Pt-Cocatalyst-Loaded TiO2 Nanoparticles

2019 / Bulletin of the Chemical Society of Japan

We have systematically prepared three kinds of photosensitizing (PS) double layers on the surface of Pt-cocatalyst-loaded TiO2 (Pt-TiO2) nanoparticles by using… Continue reading A Systematic Study on the Double-Layered Photosensitizing Dye Structure on the Surface of Pt-Cocatalyst-Loaded TiO2 Nanoparticles

Physicochemical properties and oil/water interfacial adsorption behavior of cod proteins as affected by high-pressure homogenization

2020 / Food Hydrocolloids

Atlantic cod (Gadus morhua), with the largest fishing amount worldwide, is commonly consumed as low value-added products, yet is regarded… Continue reading Physicochemical properties and oil/water interfacial adsorption behavior of cod proteins as affected by high-pressure homogenization

Kinetic and thermodynamic insights into interaction of albumin with piperacillin: Spectroscopic and molecular modeling approaches

2019 / Journal of Molecular Liquids

The current study investigated the binding of BSA and piperacillin at multifarious concentrations (1–128 μM) along with four different temperatures. To… Continue reading Kinetic and thermodynamic insights into interaction of albumin with piperacillin: Spectroscopic and molecular modeling approaches

Probing the Interfacial Interactions of Monoclonal and Bispecific Antibodies at the Silicone Oil–Aqueous Solution Interface by Using Sum Frequency Generation Vibrational Spectroscopy

2019 / Langmuir

Silicone oil has been widely utilized in the pharmaceutical industry especially as a lubricant coating commonly used in syringes for… Continue reading Probing the Interfacial Interactions of Monoclonal and Bispecific Antibodies at the Silicone Oil–Aqueous Solution Interface by Using Sum Frequency Generation Vibrational Spectroscopy

Polycyclic furanobutenolide-derived norditerpenoids from the South China Sea soft corals Sinularia scabra and Sinularia polydactyla with immunosuppressive activity

2019 / Bioorganic Chemistry

One new polycyclic furanobutenolide-derived norcembranoid, xiguscabrolide H (1), together with eleven known related norditerpenoids 2–12 were isolated from South China Sea soft… Continue reading Polycyclic furanobutenolide-derived norditerpenoids from the South China Sea soft corals Sinularia scabra and Sinularia polydactyla with immunosuppressive activity

The Removal of Uranium and Thorium from Their Aqueous Solutions by 8-Hydroxyquinoline Immobilized Bentonite

2019 / Minerals

The sorption of uranium and thorium from their aqueous solutions by using 8-hydroxyquinoline modified Na-bentonite (HQ-bentonite) was investigated by the… Continue reading The Removal of Uranium and Thorium from Their Aqueous Solutions by 8-Hydroxyquinoline Immobilized Bentonite

Binuclear Schiff base copper(II) complexes: Syntheses, crystal structures, HSA interaction and anti-cancer properties

2020 / Inorganica Chimica Acta

Three binuclear Schiff base copper(II) complexes: [Cu2(HL1)2(CH3OH)(NO3)]·NO3 (1), [Cu2(HL2)2(CH3OH)2]·2NO3 (2), and [Cu2(HL3)2(C2H5OH)2]·2NO3 (3) [HL1 = (E)-N′-(5-fluoro-2-hydroxybenzylidene)benzohydrazide, HL2 = (E)-N′-(5-chloro-2-hydroxybenzylidene)benzohydrazide, and HL3 = (E)-N′-(5-bromo-2-hydroxybenzylidene)benzohydrazide], were synthesized and characterized employing various… Continue reading Binuclear Schiff base copper(II) complexes: Syntheses, crystal structures, HSA interaction and anti-cancer properties

A new tridentate fluorescent-colorimetric chemosensor for copper(II) ion

2019 / Tetrahedron

A new tri-imidazolium salt, tris(4-(3-(2-((8-hydroxy-9,10-dioxo-9′,10′-dihydroanthracen-1-yl)oxy)ethyl)-1H-imidazole-3′-ium-1′-yl)phenyl)amine hexafluorophosphate was prepared and characterized. Particularly, the recognition performance of the tri-imidazolium salt for cations… Continue reading A new tridentate fluorescent-colorimetric chemosensor for copper(II) ion

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