Found 9617 Results / Page 21 of 481
2022 / Scientific Reports
Phosphoglycerate kinase has been a model for the stability, folding cooperativity and catalysis of a two-domain protein. The human isoform… Continue reading Loss of stability and unfolding cooperativity in hPGK1 upon gradual structural perturbation of its N-terminal domain hydrophobic core
2022 / Molecular Phychiatry
St. John’s wort is an herb, long used in folk medicine for the treatment of mild depression. Its antidepressant constituent,… Continue reading Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs
2022 / Scientific Reports
This study presents the synthesis and doping of reduced graphene oxide (rGO) with synthesized porphyrin (5,15-bisdodecyl porphyrin, C12P) nanoparticles to… Continue reading Synthesis and applicability of reduced graphene oxide/porphyrin nanocomposite as photocatalyst for waste water treatment and medical applications
2022 / Communications Chemistry
Since imine reductases (IREDs) were reported to catalyze the reductive amination reactions, they became particularly attractive for producing chiral amines.… Continue reading Actinomycetes-derived imine reductases with a preference towards bulky amine substrates
2022 / SAGE Journals Applied Spectroscopy OnlineFirst
Circular dichroism (CD) spectroscopy is a widely used technique for assessing the higher-order structure (HOS) of biopharmaceuticals, including antibody drugs.… Continue reading Performance Comparison of Spectral Distance Calculation Methods
2021 / Evolutionary Biology
We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although… Continue reading Reduced purine biosynthesis in humans after their divergence from Neandertals
2022 / Scientific Reports
Dynein light chain LC8 is a small dimeric hub protein that recognizes its partners through short linear motifs and is… Continue reading The interaction between LC8 and LCA5 reveals a novel oligomerization function of LC8 in the ciliary-centrosome system
2022 / npj Clean Water
In this study, a hydrated iron-alum oxides-contained cation exchange resin (HIAO/225H) was synthesized for the first time from natural alum-ferric… Continue reading Advanced natural hydrated iron-alum oxides cation exchange resin for simultaneous phosphate and hardness removal
2022 / Scientific Reports
Nanotechnology is one of the most impressive sciences in the twenty-first century. Not surprisingly, nanoparticles/nanomaterials have been widely deployed given… Continue reading Bioengineering of CuO porous (nano)particles: role of surface amination in biological, antibacterial, and photocatalytic activity
2022 / FEBS openbio
Hydroxymethylbilane synthase (HMBS) is the third enzyme involved in haem biosynthesis, in which it catalyses the formation of tetrapyrrole 1-hydroxymethylbilane… Continue reading Characterisation of a common hotspot variant in acute intermittent porphyria sheds light on the mechanism of hydroxymethylbilane synthase function
2022 / Biotechnology and Bioengineering
Cell-free heme, which was previously shown to have adverse effects on the innate immune system, does not induce inflammation when… Continue reading Scalable manufacturing platform for the production of PEGylated heme albumin
2022 / Chemistry An Asian Journal
Despite the rapid progress of organic electronics, developing high-performance n-type organic semiconductors is still challenging. Donor-acceptor (D-A) type conjugated structures… Continue reading Benzothiadiazole versus Thiazolobenzotriazole: A Structural Study of Electron Acceptors in Solution-Processable Organic Semiconductors
2022 / Advanced PHOTONICS RESEARCH
Current research on multispectral stealth material technology focuses on practical functionalities such as optical transparency, flexibility, and lightweight. Herein, an… Continue reading Optically Transparent Single-Layer Frequency-Selective Surface Absorber for Dual-Band Millimeter-Wave Absorption and Low-Infrared Emissivity
2022 / High Voltage
Two kinds of epoxy resin, a soft one with rubber-based additives and an ordinary hard one, are used as electrical… Continue reading Thermal ageing of soft and hard epoxy resins
2022 / Nature Communications
Efficient water vapor splitting opens a new strategy to develop scalable and corrosion-free solar-energy-harvesting systems. This study demonstrates highly efficient… Continue reading A hygroscopic nano-membrane coating achieves efficient vapor-fed photocatalytic water splitting
2022 / Nature Communications
Au catalysts have drawn broad attention for catalytic CO oxidation. However, a molecular-level understanding of the reaction mechanism on a… Continue reading A self-complementary macrocycle by a dual interaction system
2022 / Nature Communications
Chiral mesostructures exhibit distinctive twisting and helical hierarchical stacking ranging from atomic to micrometre scales with fascinating structural-chiral anisotropy properties.… Continue reading Synchronous quantitative analysis of chiral mesostructured inorganic crystals by 3D electron diffraction tomography
2022 / Nature Communications
The human insulin receptor signalling system plays a critical role in glucose homeostasis. Insulin binding brings about extensive conformational change… Continue reading Activation of the human insulin receptor by non-insulin-related peptides
2022 / Scientific Reports
Highest global cancer incidence of female breast cancer is a matter of great concern. HER2-positive breast cancers have high mortality… Continue reading Synthesis and comparative evaluation of 177Lu-labeled PEG and non-PEG variant peptides as HER2-targeting probes
2022 / Nature Communications
The moon’s monthly cycle synchronizes reproduction in countless marine organisms. The mass-spawning bristle worm Platynereis dumerilii uses an endogenous monthly… Continue reading A Cryptochrome adopts distinct moon- and sunlight states and functions as sun- versus moonlight interpreter in monthly oscillator entrainment
