Two new chiral bis-bidentate, C2-symmetrical ligands belonging to the Chiragen family have been synthesised and characterised. They are designed for… Continue reading Self-assembly of Ag(I) helicates with new enantiopure 5,6-Chiragen type ligands
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Marine industry waste is rich in the extracellular structural protein collagen, excised fragments of which are known to display numerous… Continue reading Utilization of marine industry waste derived collagen hydrolysate as peroxide inhibition agents in lipid-based food
Leah Pandiscia, PhD
October 11, 2018
The cellular trafficking of numerous G protein-coupled receptors (GPCRs) is known to be regulated by Rab proteins that involves a direct protein:protein interaction between the receptor… Continue reading Identification of α-helix 4 (α4) of Rab11a as a novel Rab11-binding domain (RBD): Interaction of Rab11a with the Prostacyclin Receptor
Leah Pandiscia, PhD
October 11, 2018
Membrane-active antibiotics are potential alternatives to the resistance-prone conventional antibiotics. Daptomycin, a cyclic lipopeptide, is the only membrane-active antibiotic approved… Continue reading Molecular State of the Membrane-Active Antibiotic Daptomycin
Leah Pandiscia, PhD
October 11, 2018
Lipid membranes interact with and influence the aggregation of many amyloid-forming proteins. Orb2 is a cytoplasmic polyadenylation element-binding protein homolog… Continue reading The Functional Amyloid Orb2A Binds to Lipid Membranes
Leah Pandiscia, PhD
October 11, 2018
Guanine-rich sequences may fold into highly ordered structures known as G-quadruplexes. Apart from the monomeric G-quadruplex, these sequences may form… Continue reading Evaluation of the effect of polymorphism on G-quadruplex-ligand interaction by means of spectroscopic and chromatographic techniques
Leah Pandiscia, PhD
October 11, 2018
The objective of this study was to evaluate the effects of the natural safety high antimicrobial compounds on egg yolk… Continue reading Influence of bio-active terpenes on the characteristics and functional properties of egg yolk
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
New Delhi metallo β-lactamase-1 is one of the carbapenemases, causing hydrolysis of almost all β-lactamase antibiotics. Seventeen different NDM variants have been reported… Continue reading Non-active site mutation (Q123A) in New Delhi metallo-β-lactamase (NDM-1) enhanced its enzyme activity
Leah Pandiscia, PhD
October 11, 2018
Kluyveromyces lactis is a common fungal microorganism used for the production of enzyme preparations such as β-galactosidases (native) or chymosin (recombinant). It… Continue reading A natural variant of arylsulfatase from Kluyveromyces lactis shows no formylglycine modification and has no enzyme activity
Leah Pandiscia, PhD
October 11, 2018
The Amazon region holds most of the biological richness of Brazil. Despite their ecological and biotechnological importance, studies related to… Continue reading A novel β-glucosidase isolated from the microbial metagenome of Lake Poraquê (Amazon, Brazil)
Leah Pandiscia, PhD
October 11, 2018
Seaweeds are sources of biomolecules with biological activities and pharmacological potential – for example, lectins, a group of proteins that can… Continue reading Lectin obtained from the red seaweed Bryothamnion triquetrum: Secondary structure and anti-inflammatory activity in mice
Leah Pandiscia, PhD
October 11, 2018
The structure and biophysical properties of endo β-1,4-xylanase (PsGH10A) of family 10 glycoside hydrolase were characterized. The modeled PsGH10A structure showed classical (β/α)8-barrel… Continue reading Low-resolution SAXS and comparative modeling based structure analysis of endo-β-1,4-xylanase a family 10 glycoside hydrolase from Pseudopedobacter saltans comb. nov.
Leah Pandiscia, PhD
October 11, 2018
Response surface methodology (RSM) was used to optimize the fermentation condition of exopolysaccharide (EPS) producing strain Leuconostoc mesenteroidesDRP105. Result showed that… Continue reading Optimization, chain conformation and characterization of exopolysaccharide isolated from Leuconostoc mesenteroides DRP105
Leah Pandiscia, PhD
October 11, 2018
Eight known compounds and one new compound, a eudesmane-type sesquiterpene (1), were isolated from the leaves of Artemisia vulgaris. Their structures… Continue reading A New Eudesmane-Type Sesquiterpene from the Leaves of Artemisia vulgaris
Leah Pandiscia, PhD
October 11, 2018
STAT1 and STAT3 are two transcription factors involved in a lot of cellular functions such as immune response, proliferation, apoptosis,… Continue reading S-glutathionylation exerts opposing roles in the regulation of STAT1 and STAT3 signaling in reactive microglia
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Sticholysin II (StII) is a pore-forming actinoporin from the sea anemone Stichodactyla helianthus. A mechanistic model of its action has been… Continue reading Insights on the structure-activity relationship of peptides derived from Sticholysin II
Leah Pandiscia, PhD
October 11, 2018
The guanine-rich RNA sequence binding factor 1 (GRSF1) constitutes an ubiquitously occurring RNA-binding protein (RBP), which belongs to the family of heterogeneous nuclear… Continue reading Functional characterization of naturally occurring genetic variations of the human guanine-rich RNA sequence binding factor 1 (GRSF1)
Leah Pandiscia, PhD
October 11, 2018