A pentavalent branched‐chain polyamine, N4‐bis(aminopropyl)spermidine [3(3)(3)4], is a unique polycation found in a hyperthermophilic archaeon Thermococcus kodakarensis that grows at… Continue reading Branched‐chain polyamine found in hyperthermophiles induces unique temperature‐dependent structural changes in genome‐size DNA
Leah Pandiscia, PhD
August 13, 2018
Papillomavirus oncoprotein E6 is a critical factor in the modulation of cervical cancer in humans. At the molecular level, formation… Continue reading A Cu2+ complex induces the aggregation of human papillomavirus oncoprotein E6 and stabilizes p53
Leah Pandiscia, PhD
August 13, 2018
Molecular organization of electron-deficient aromatic systems like perylenediimides (PDI) is extremely appealing, as they are potential candidates for organic electronics.… Continue reading Solvent Directed Morphogenesis and Electrical Properties of a Peptide-Perylenediimide Conjugate
Leah Pandiscia, PhD
August 13, 2018
An easy-operation, celerity and high selectivity method, which applied unmodified Gold nanorods (GNRs) as a chiral nanosensor for the chiral… Continue reading A new nanosensor for the chiral recognition of cysteine enantiomers based on gold nanorods
Leah Pandiscia, PhD
August 13, 2018
Dynamic modulation of lipid membrane curvature can be achieved by a number of peripheral protein binding mechanisms such as hy-drophobic… Continue reading Peripheral Protein Unfolding Drives Membrane Bending
Leah Pandiscia, PhD
August 13, 2018
The spherical form (s-form) of a genetically-modified gold-binding M13 bacteriophage was investigated as a scaffold for gold synthesis. Repeated mixing… Continue reading M13 bacteriophage spheroids as scaffolds for directed synthesis of spiky gold nanostructures
Leah Pandiscia, PhD
August 13, 2018
With the rise in diabetes mellitus cases worldwide and lack of patient adherence to glycemia management using injectable insulin, there… Continue reading Ionic liquids for oral insulin delivery
Leah Pandiscia, PhD
August 13, 2018
Highly pathogenic avian influenza virus (HPAIV) infections have occurred continuously and crossed the species barrier to humans, leading to fatalities.… Continue reading Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism
Leah Pandiscia, PhD
August 13, 2018
AIDS has evolved from a fatal infectious disease to a manageable chronic disease under the treatment of anti-AIDS medications. HIV… Continue reading Generation of a long-acting fusion inhibitor against HIV-1
Leah Pandiscia, PhD
August 13, 2018
Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein,… Continue reading Protein engineering allows for mild affinity-based elution of therapeutic antibodies
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Herein, we report the synthesis of simple TPE/single amino acid conjugates, TPE-Ser and TPE-Asp with side-chains featuring functional groups that may provide an additional… Continue reading Fluorescent supramolecular hydrogels self-assembled from tetraphenylethene (TPE)/single amino acid conjugates
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Elastin-like polypeptide (ELP)-based drug delivery has been utilized for various applications including cancer therapies for many years. Genetic incorporation of… Continue reading Multivalent Targeting Based Delivery of Therapeutic Peptide using AP1-ELP Carrier for Effective Cancer Therapy
Leah Pandiscia, PhD
August 13, 2018
The development of high performance thermal management materials to dissipate excessive heat both in-plane and through–plane is of special interest,… Continue reading Coupled chiral structure in graphene-based film for ultrahigh thermal conductivity both in-plane and through-plane directions
Leah Pandiscia, PhD
August 13, 2018
Hybrid nucleotide-lipids composed of a lipid covalently attached to purine and pyrimidine nucleobases exhibit supramolecular properties. The novel cytidine and… Continue reading Cytidine- and guanosine-based nucleotide-lipids
Leah Pandiscia, PhD
August 13, 2018
PTPRJ is a receptor‐like protein tyrosine phosphatase mainly known for its antiproliferative and tumor‐suppressive functions. PTPRJ dephosphorylates several growth factors… Continue reading Design, Synthesis, Biological Activity and Structural Analysis of lactam‐constrained PTPRJ agonist peptides
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
The organization of molecules into cells is believed to have been critical for the emergence of living systems. Early protocells… Continue reading Lipid vesicles chaperone an encapsulated RNA aptamer
Leah Pandiscia, PhD
August 13, 2018