Found 9617 Results / Page 282 of 481
2018 / Biochemistry
Telomere repeat binding factor 2 (TRF2) is critical for the protection of chromosome ends. Mounting evidence suggests that TRF2 associates… Continue reading Extratelomeric Binding of the Telomere Binding Protein TRF2 at the PCGF3 Promoter Is G-Quadruplex Motif-Dependent
2018 / The Journal of Organic Chemistry
N-Alkylbenzanilides generally exist in cis conformation both in the crystalline state and in various solvents, and this cis conformational preference… Continue reading Conformational Properties of Aromatic Oligoamides Bearing Pyrrole Rings
2018 / Journal of Natural Products
Five new dibenzocyclooctadiene lignans, longipedlignans A–E (1–5), five new tetrahydrobenzocyclooctabenzofuranones (6–10), and 18 known analogues (11–28) were isolated from the… Continue reading Hepatoprotective Dibenzocyclooctadiene and Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata
2018 / Biochemistry
The cell membranes of all archaea contain ether lipids, and a number of archaea are hyperthermophilic. Consequently, the enzymes that… Continue reading Hexamerization of geranylgeranylglyceryl phosphate synthase ensures structural integrity and catalytic activity at high temperatures
2018 / Biochemistry
Shigella rely entirely on the action of a single type three secretion system (T3SS) to support cellular invasion of colonic epithelial… Continue reading MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47
2018 / ACS Chemical Neuroscience
α-Synuclein (aS) forms toxic intermediates ranging from small oligomers and protofibrils to large amyloid fibrils. Understanding the time course of… Continue reading Pulsed Hydrogen–Deuterium Exchange Illuminates the Aggregation Kinetics of α-Synuclein, the Causative Agent for Parkinson’s Disease
2018 / Biochemistry
Gelsolin is an actin-severing protein that attains an open functional conformation in the presence of Ca2+ or low pH. Mutations… Continue reading The Gelsolin Pathogenic D187N Mutant Exhibits Altered Conformational Stability and Forms Amyloidogenic Oligomers
2018 / Chemistry A European Journal
Small molecules that target G‐quadruplex (G4) DNA structures are not only valuable to study G4 biology but also for their… Continue reading Flexible versus rigid G‐quadruplex DNA ligands ‐ synthesis of two series of bis‐indole derivatives and comparison of their interactions with G‐quadruplex DNA.
2018 / Polymer Chemistry
In this contribution, we report the first odd–even and side chain length dependence on the chiral induction of achiral polydialkylfluorenes… Continue reading Chirality induction of achiral polydialkylfluorenes by chiral solvation: odd–even and side chain length dependence
2018 / Inorganic Chemistry
Halterman corroles have been synthesized for the first time from pyrrole and Halterman’s aldehyde via Gryko’s “water–methanol method”. These were… Continue reading Halterman Corroles and Their Use as a Probe of the Conformational Dynamics of the Inherently Chiral Copper Corrole Chromophore
2018 / JACS
Oxidation is one of the frequent causes of DNA damage, especially to guanine bases. Guanine bases in the G-quadruplex (G4)… Continue reading Recovery of the Formation and Function of Oxidized G-Quadruplexes by a Pyrene-Modified Guanine Tract
2018 / Macromolecules
A series of d-glucose-bound optically active π-conjugated polymers (poly-Tr) were synthesized by ternary copolymerization of 2,5-diiodothiophene with diethynyl monomers containing a… Continue reading Chiral Amplification in π-Conjugated Helical Polymers with Circularly Polarized Luminescence
2018 / ChemPhysChem
Over the years, a large number of multidisciplinary investigations has unveiled that the self‐assembly of short peptides and even of… Continue reading Structural characterization of self‐assembled tetra‐tryptophan based nanostructures: variations on a common theme
2018 / RSC Advances
The interest in developing functional biomaterials based on designed peptides has been increasing in recent years. The amphiphilic and anionic… Continue reading RGD-presenting peptides in amphiphilic and anionic β-sheet hydrogels for improved interactions with cells
2018 / Analytical Chemistry
This work aims to face the challenge of monitoring small molecule drugs accurately and rapidly for point-of-care (POC) diagnosis in… Continue reading Point-of-Care Determination of Acetaminophen Levels with Multi-Hydrogen Bond Manipulated Single-Molecule Recognition (eMuHSiR)
2018 / Dalton Transactions
Chiral recognition of DNA molecules is important because much evidence has indicated that transformations of chirality and diverse conformations of… Continue reading Regulation of multi-factors (tail/loop/link/ions) for G-quadruplex enantioselectivity of Δ- and Λ-[Ru(bpy)2(dppz-idzo)]2+
2018 / Scientific Reports
Human Tousled-like kinases (TLKs) are highly conserved serine/threonine protein kinases responsible for cell proliferation, DNA repair, and genome surveillance. Their… Continue reading High yield bacterial expression, purification and characterisation of bioactive Human Tousled-like Kinase 1B involved in cancer
2018 / Journal of Molecular Structure
A simple and efficient approach leading to a well functionalized helically chiral π-conjugated system is reported. Optical resolution of racemic… Continue reading Synthesis, enantiomeric resolution and photophysical properties of 7-cyano-14-methoxy-5-thiahexahelicene
2018 / Cellular and Molecular Life Sciences
Human carbonic anhydrase IX (hCA IX) is a tumour-associated enzyme present in a limited number of normal tissues, but overexpressed… Continue reading Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX
2018 / Physical Chemistry Chemical Physics
Type 2 diabetes mellitus and Alzheimer’s disease are characterized by the accumulation of fibrillar amyloid deposits consisting mainly of islet… Continue reading Time dependence of NMR observables reveals salient differences in the accumulation of early aggregated species between human islet amyloid polypeptide and amyloid-β
