Found 9617 Results / Page 344 of 481
2017 / The FEBS Journal
Amyloid β (Aβ) peptide plays a major role in Alzheimer’s disease (AD) and occurs in multiple forms, including pyroglutamylated Aβ… Continue reading Unmodified and pyroglutamylated amyloid β peptides form hypertoxic hetero-oligomers of unique secondary structure
2017 / International Journal of Biological Macromolecules
The interaction of 5H-naptho[2,1-f][1,2]oxathieaphine2,2-dioxide (NOTD) with calf thymus DNA in Tris-HCl buffer at physiological pH was investigated with the help… Continue reading Spectroscopic, electrochemical and molecular docking study of the binding interaction of a small molecule 5H-naptho[2,1-f][1,2] oxathieaphine 2,2-dioxide with calf thymus DNA
2017 / International Journal of Biological Macromolecules
Present study was conducted to establish the interaction of bovine fetuin-A to validate its binding modalities with doxorubicin (Dox). Fetuin-A… Continue reading Protein–Drug Nanoconjugates: Finding the alternative proteins as drug carrier
2017 / Biochimie
Imposition of different biotic and abiotic stress conditions results in an increase in intracellular levels of Ca2+ which is sensed by… Continue reading A temperature-responsive gene in sorghum encodes a glycine-rich protein that interacts with calmodulin
2017 / Inorganica Chimica Acta
The oxime based ligand, 3-(thiophen-3-yl-methylene-hydrazono)-butan-2-one oxime, has been synthesised by the 1:1 Schiff-base condensation of diacetyl-monoxime monohydrazone with thiophene-2-carboxaldehyde in… Continue reading Synthesis, characterization, structure and DNA binding aspects of a trinuclear copper(II) complex having a Cu3O core
2017 / International Journal of Biological Macromolecules
Number of incurable diseases associated with neurodegenerative syndromes like Alzheimer’s, and Parkinson’s, are owing to protein aggregation which leads to… Continue reading Diameter of the Vial Plays a Crucial Role in the Amyloid Fibril Formation: Role of Interface Area between Hydrophilic-Hydrophobic Surfaces
2017 / International Journal of Biological Macromolecules
Firefly luciferase is susceptible to thermal inactivation, thereby its intracellular half-life decreased. Previous reports indicated that L300R mutation (LRR mutant)… Continue reading Bifunctional role of leucine 300 of firefly luciferase in structural rigidity
2017 / International Journal of Biological Macromolecules
This work examines fibro-proliferation through interaction of myoglobin (Mb), a globular protein with collagen, an extracellular matrix fibrous protein. Designed… Continue reading Initiating Fibro-proliferation through Interfacial interactions of Myoglobin Colloids with Collagen in solution
2017 / Journal of Molecular Biology
Protein aggregation remains a major area of focus in the production of monoclonal antibodies. Improving the intrinsic properties of antibodies… Continue reading Prediction and reduction of the aggregation of monoclonal antibodies
2017 / Journal of Molecular Structure
The interactions of boron cluster compounds closo-borates with biomolecules are widely studied due to their efficiency as agents for boron… Continue reading Effective binding of perhalogenated closo-borates to serum albumins revealed by spectroscopic and ITC studies
2017 / Protein Expression and Purification
Protein refolding from inclusion bodies (IBs) often encounters a problem of low recovery at high protein concentration. In this study,… Continue reading High hydrostatic pressure enables almost 100% refolding of recombinant human ciliary neurotrophic factor from inclusion bodies at high concentration
2017 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
New Schiff base complexes [Cu(L1)Cl] (1), [Ni(L1)Cl] (2), [Zn(L1)Cl] (3), and [Fe(L2)H2OCl] (4) {L1 = (4E)-3-(2-hydroxybenzylidene)-4-(2-hydroxyphenylimino)pentan-2-one, L2 = 2,2′-(1E,1′E)-(3-(2-hydroxybenzylidene)-pentane-2,4-diylidene)bis(azan-1-yl-1 idene)diphenol} have been synthesized and characterized… Continue reading Non-enolisable Knoevenagel condensate appended Schiff bases-metal (II) complexes: Spectral characteristics, DNA-binding and nuclease activities
2017 / Protein Expression and Purification
Apolipoprotein (apo) A-I is the major protein component of high-density lipoprotein (HDL) and plays key roles in the Reverse Cholesterol… Continue reading A facile method for isolation of recombinant human apolipoprotein A-I from E. coli
2017 / Environmental Toxicology and Pharmacology
The physicochemical properties of polybrominated diphenyl ethers are important for modeling their transport, but these data are often missing. Here,… Continue reading Investigating the affinity of BDE154 and 3OH-BDE154 with HSA: Experimental and simulation validation
2017 / PLoS ONE
TNF-like 1A (TL1A) is a cytokine belonging to the TNF superfamily that promotes inflammation in autoimmune diseases. Inhibiting the interaction… Continue reading Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion
2017 / Nanoscale
DNA nanostructures have found potential applications in various fields including nanotechnology, materials science and nanomedicine, hence the design and synthesis… Continue reading Modular synthesis of supramolecular DNA amphiphiles through host–guest interactions and their self-assembly into DNA-decorated nanovesicles
2017 / Scientific Reports
Chirality is one of the most intriguing properties of matter related to a molecule’s lack of mirror symmetry. The transmission… Continue reading Spatial control of chirality in supramolecular aggregates
2017 / Photochemical & Photobiological Sciences
A europium(III) complex with a large π-conjugated helical ligand, tris(hexafluoroacetylacetonato)europium(III)bis((pentahelicenyl)diphenylphosphine oxide) (Eu(hfa)3(HPO)2), exhibits dual luminescence excited at the π–π* transition… Continue reading Solvent-dependent dual-luminescence properties of a europium complex with helical π-conjugated ligands
2017 / The Journal of Biological Chemistry
Nitrovasodilators relax vascular smooth muscle cells (VSMC) in part by modulating the interaction of the C-terminal coiled-coil domain (CC) and/or… Continue reading NMR Insight into Myosin-Binding Subunit Coiled Coil Structure Reveals Binding Interface with Protein Kinase G-Iα Leucine Zipper in Vascular Function.
2017 / Chemistry A European Journal
A benzothiazole derivative was identified as potent ligand for DNA G-quadruplex structures. Fluorescence titrations revealed selective binding to quadruplexes of… Continue reading Selective Targeting of G-Quadruplex Structures by a Benzothiazole-Based Binding Motif
