KnowledgeBase Articles Archive

LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity

2017 / Biochimica et Biophysica Acta (BBA) - Biomembranes

Although the human-derived antimicrobial peptide (AMP) LL-37 has potent antimicrobial and anti-inflammatory activities, its therapeutic application is limited by its… Continue reading LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity

Immune response and protective profile elicited by a multi-epitope chimeric protein derived from Leptospira interrogans

2017 / International Journal of Infectious Diseases

Pathogenic Leptospirais the causative agent of leptospirosis, a wide disseminated disease of human and veterinary concern. The development ofvaccines that… Continue reading Immune response and protective profile elicited by a multi-epitope chimeric protein derived from Leptospira interrogans

Cell-penetrating and cargo-delivery ability of a spider toxin-derived peptide in mammalian cells

2017 / European Journal of Pharmaceutics and Biopharmaceutics

Cell-penetrating peptides are short cationic peptides with inherent ability to cross the plasma membrane barrier as well as intracellularly deliver… Continue reading Cell-penetrating and cargo-delivery ability of a spider toxin-derived peptide in mammalian cells

Expression and characterization of haemathrins, madanin-like thrombin inhibitors, isolated from the salivary gland of tick Haemaphysalis bispinosa (Acari: Ixodidae)

2017 / Thrombosis Research

Saliva of hematophagous animals, such as ticks, is an excellent source of anticoagulant proteins and polypeptides. Here we describe the… Continue reading Expression and characterization of haemathrins, madanin-like thrombin inhibitors, isolated from the salivary gland of tick Haemaphysalis bispinosa (Acari: Ixodidae)

Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis

2017 / Scientific Reports

Eugenol has attracted considerable attention because of its potential for many pharmaceutical applications including anti-inflammatory, anti-tumorigenic and anti-oxidant properties. Here,… Continue reading Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis

Pairing Alpaca and Llama-Derived Single Domain Antibodies to Enhance Immunoassays for Ricin

2017 / Antibodies

Previously, our group isolated and evaluated anti-ricin single domain antibodies (sdAbs) derived from llamas, engineered them to further increase their… Continue reading Pairing Alpaca and Llama-Derived Single Domain Antibodies to Enhance Immunoassays for Ricin

Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β

2017 / The Journal of Biological Chemistry

The aggregation of amyloid-Aβ (Aβ) on lipid bilayers has been implicated as a mechanism by which Aβ exerts its toxicity… Continue reading Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β

Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters

2017 / Bioorganic & Medicinal Chemistry

Cell-penetrating peptides (CPP) have attracted many scientists’ attention as intracellular delivery tools due to their high cargo molecule transportation efficiency… Continue reading Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters

Preparation of the Extracellular Domain of Recombinant Human Toll-like Receptor 6

2017 / The Protein Journal

Toll-like receptors (TLRs) mediate immune responses upon recognition of a variety of ligands. To further elucidate the function of TLRs,… Continue reading Preparation of the Extracellular Domain of Recombinant Human Toll-like Receptor 6

Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis

2017 / Scientific Reports

CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults.… Continue reading Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis

An epigenetic modifier induces production of (10′S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla

2017 / Bioorganic & Medicinal Chemistry

Incorporation of the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), to a culture broth of the endophytic fungus Phoma sp. nov.… Continue reading An epigenetic modifier induces production of (10′S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla

The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding

2017 / International Journal of Peptide Research and Therapeutics

Three novel analogues of salivary peptides as sialorphin (QHNPR) and opiorphin (QRFSR) were synthesized by the solid-phase method. The sequences… Continue reading The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding

Structural, thermodynamic, and phosphatidylinositol 3-phosphate binding properties of Phafin2

2017 / Protein Science

Phafin2 is a phosphatidylinositol 3-phosphate (PtdIns(3)P) binding protein involved in the regulation of endosomal cargo trafficking and lysosomal induction of… Continue reading Structural, thermodynamic, and phosphatidylinositol 3-phosphate binding properties of Phafin2

Aristolochic acid derivatives from the rhizome of Arisolochia championii

2017 / Fitoterapia

Four new aristolochic acid derivatives aristchamic A (1), aristchamic B (2), aristochamic C (3a), aristchamic D (3b) and one new… Continue reading Aristolochic acid derivatives from the rhizome of Arisolochia championii

Apela exhibits isoform- and headgroup-dependent modulation of micelle binding, peptide conformation and dynamics

2017 / Biochimica et Biophysica Acta (BBA) - Biomembranes

Apela (also referred to as ELABELA and toddler) is a peptide hormone that activates the apelin receptor (AR or APJ)… Continue reading Apela exhibits isoform- and headgroup-dependent modulation of micelle binding, peptide conformation and dynamics

Novel human bioactive peptides identified in Apolipoprotein B: Evaluation of their therapeutic potential

2017 / Biochemical Pharmacology

Host defence peptides (HDPs) are short, cationic amphipathic peptides that play a key role in the response to infection and… Continue reading Novel human bioactive peptides identified in Apolipoprotein B: Evaluation of their therapeutic potential

Tea silkworm droppings as an enriched source of tea flavonoids

2017 / Journal of Food and Drug Analysis

Andraca droppings are the waste excreted by the tea biter, Andraca theae. Their chemical constituents and potential medical use, unlike those of… Continue reading Tea silkworm droppings as an enriched source of tea flavonoids

Distinct optoelectronic properties of four-coordinate and five-coordinate Zn(II) complexes with chiral polypyridine ligands

2017 / Polyhedron

Two pairs of chiral Zn(II) complexes, Zn((−)-L1)Cl2 ((−)-1) and Zn((+)-L1)Cl2 ((+)-1), Zn((−)-L2)Cl2 ((−)-2) and Zn((+)-L2)Cl2 ((+)-2), [(−)-L1 = (−)-4,5-pinene bipyridine, (+)-L1= (+)-4,5-pinene bipyridine, (−)-L2 = (−)-‘dipineno’-[4,5:4″,5″]-fused… Continue reading Distinct optoelectronic properties of four-coordinate and five-coordinate Zn(II) complexes with chiral polypyridine ligands

A selective chemosensor for fluoride ion and its interaction with Calf Thymus DNA

2017 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

The amido-Schiff base 1 (N1, N3-bis (2-nitrobenzylidene)benzene-1,3-dicabohydrazide) containing a single bondCONHsingle bond group and single bondCHdouble bond; length as m-dashNsingle bond linkage has been synthesized by… Continue reading A selective chemosensor for fluoride ion and its interaction with Calf Thymus DNA

Chemical constituents from the flowers of wild Gardenia jasminoides Ellis

2017 / Chemistry & Biodiversity

Four new iridoids, 2’-O-trans-coumaroylshanzhiside (1), 6’-O-trans-coumaroyl- shanzhiside (2), 8α-butylgardenoside B (3), 6α-methoxygenipin (4), and one new phenylpropanoid glucoside, 4-methoxy-benzenepropanol-3-O-β-D-glucopyranoside (5),… Continue reading Chemical constituents from the flowers of wild Gardenia jasminoides Ellis

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