KnowledgeBase Articles Archive

Exploring the interaction of phenothiazinium dyes methylene blue, new methylene blue, azure A and azure B with tRNAPhe : Spectroscopic, thermodynamic, voltammetric and molecular modeling approach

2017 / Physical Chemistry Chemical Physics

This study focuses to understand the interaction of phenothiazinium dyes methylene blue (MB), new methylene blue (NMB), azure A (AZA)… Continue reading Exploring the interaction of phenothiazinium dyes methylene blue, new methylene blue, azure A and azure B with tRNAPhe : Spectroscopic, thermodynamic, voltammetric and molecular modeling approach

Self-Directing Chiral Information in Solid-Solid Transformation: Unusual Chiral-Transfer without Racemization from Amorphous Silica to Crystalline Silicon

2017 / Nanoscale Horizons

Constructing novel chiral inorganic nanomaterials is an emerging branch in chirality research. In this work, employingng a solid magnesiothermic reaction… Continue reading Self-Directing Chiral Information in Solid-Solid Transformation: Unusual Chiral-Transfer without Racemization from Amorphous Silica to Crystalline Silicon

Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains

2017 / Scientific Reports

Antibody light chain amyloidosis is a rare disease caused by fibril formation of secreted immunoglobulin light chains (LCs). The huge… Continue reading Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains

Anti-neuroinflammatory asarone derivatives from the rhizomes of Acorus tatarinowii

2017 / RSC Advances

A novel 7-O-7′ type mesomeric neolignan, meso-asarolignan A (1), six pairs of new neolignan enantiomers, (±)-asarolignan B–G (2a/2b, 3a/3b, 4–6, 7a/7b), along with 16… Continue reading Anti-neuroinflammatory asarone derivatives from the rhizomes of Acorus tatarinowii

Circularly polarized luminescence based chirality transfer of the chiral BINOL moiety viarigid π-conjugation chain backbone structures

2017 / Polymer Chemistry

Three kinds of chiral BINOL-based polymers could be synthesized by polymerization in a Pd-catalyzed cross-coupling reaction. The resulting chiral polymers… Continue reading Circularly polarized luminescence based chirality transfer of the chiral BINOL moiety viarigid π-conjugation chain backbone structures

Understanding the Molecular Basis for Multiple Mitochondrial Dysfunctions Syndrome 1 (MMDS1) – Impact of a Disease-Causing Gly208Cys Substitution on Structure and Activity of NFU1 in the Fe/S Cluster Biosynthetic Pathway

2017 / Journal of Molecular Biology

Iron–sulfur (Fe/S) cluster-containing proteins constitute one of the largest protein classes, with varied functions that include electron transport, regulation of… Continue reading Understanding the Molecular Basis for Multiple Mitochondrial Dysfunctions Syndrome 1 (MMDS1) – Impact of a Disease-Causing Gly208Cys Substitution on Structure and Activity of NFU1 in the Fe/S Cluster Biosynthetic Pathway

Peptidic β-sheets induce Congo red-derived fluorescence to improve the sensitivity of HIV-1 p24 detection

2017 / Analytical Methods

At the early stage of HIV infection, the low concentration of HIV components seriously hinders the diagnosis of this fatal… Continue reading Peptidic β-sheets induce Congo red-derived fluorescence to improve the sensitivity of HIV-1 p24 detection

Surface shear viscosity as a macroscopic probe of amyloid fibril formation at a fluid interface

2017 / Soft Matter

Amyloidogenesis of proteins is of wide interest because amyloid structures are associated with many diseases, including Alzheimer’s and type II… Continue reading Surface shear viscosity as a macroscopic probe of amyloid fibril formation at a fluid interface

Human Gpn1 purified from bacteria binds guanine nucleotides and hydrolyzes GTP as a protein dimer stabilized by its C-terminal tail

2017 / Protein Expression and Purification

The essential GTPase Gpn1 mediates RNA polymerase II nuclear targeting and controls microtubule dynamics in yeast and human cells by… Continue reading Human Gpn1 purified from bacteria binds guanine nucleotides and hydrolyzes GTP as a protein dimer stabilized by its C-terminal tail

Cu2+ recognition by N,N′-benzylated bis(amino amides)

2017 / Dalton Transactions

Two new C2-symmetric N,N′-benzylated bis(amino amides) have been synthesised and their interaction with different transition metals studied using a variety of techniques… Continue reading Cu2+ recognition by N,N′-benzylated bis(amino amides)

Conformational and functional transitions and in silico analysis of a serine protease from Conidiobolus brefeldianus (MTCC 5185)

2017 / International Journal of Biological Macromolecules

This work describes functional and structural transitions of a novel protease isolated from Conidiobolus brefeldianus MTCC 5185 (Cprot), in detail using biophysical… Continue reading Conformational and functional transitions and in silico analysis of a serine protease from Conidiobolus brefeldianus (MTCC 5185)

Antimicrobial effects of novel peptides cOT2 and sOT2 derived from Crocodylus siamensis and Pelodiscus sinensis ovotransferrins

2017 / Biochimica et Biophysica Acta (BBA) - Biomembranes

In light of the increasing threat of bacterial drug resistance to human health on a global scale, research and development… Continue reading Antimicrobial effects of novel peptides cOT2 and sOT2 derived from Crocodylus siamensis and Pelodiscus sinensis ovotransferrins

Probing the excitonic landscape of the Chlorobaculum tepidum Fenna-Matthews-Olson (FMO) complex: a mutagenesis approach

2017 / Biochimica et Biophysica Acta (BBA) - Bioenergetics

In this paper we report the steady-state optical properties of a series of site-directed mutants in the Fenna-Matthews-Olson (FMO) complex… Continue reading Probing the excitonic landscape of the Chlorobaculum tepidum Fenna-Matthews-Olson (FMO) complex: a mutagenesis approach

SDS induced dissociation of STY3178 oligomer: experimental and molecular dynamics studies

2017 / RSC Advances

STY3178 is a yfdX protein from Salmonella Typhi. yfdX proteins occur ubiquitously in a number of virulent bacteria but their cellular localization… Continue reading SDS induced dissociation of STY3178 oligomer: experimental and molecular dynamics studies

Revealing the Effect of Protein Weak Adsorption to Nanoparticles on the Interaction between the Desorbed Protein and its Binding Partner by Surface-Enhanced Infrared Spectroelectrochemistry

2017 / Analytical Chemistry

In recent years, the properties of protein corona have attracted intense interest in the field of nano-bio interface, but a… Continue reading Revealing the Effect of Protein Weak Adsorption to Nanoparticles on the Interaction between the Desorbed Protein and its Binding Partner by Surface-Enhanced Infrared Spectroelectrochemistry

Amyloid–β 1–42 aggregation initiates its cellular uptake and cytotoxicity

2017 / The Journal of Biological Chemistry

The accumulation of amyloid β peptide(1–42) (Aβ(1–42)) in extracellular plaques is one of the pathological hallmarks of Alzheimer disease (AD).… Continue reading Amyloid–β 1–42 aggregation initiates its cellular uptake and cytotoxicity

Synthesis of chiral R/S-pseudopeptide-based Cu(II) & Zn(II) complexes for use in targeted delivery for antitumor therapy: enantiomeric discrimination with CT-DNA and pBR322 DNA hydrolytic cleavage mechanism†

2017 / RSC Advances

Chiral pseudopeptide Cu(II) and Zn(II) complexes (1S/R and 2S/R, respectively), were obtained by a de novo synthetic strategy employing pseudopeptide synthons derived from R/S-2-amino-2-phenylethanol and N-methyliminodiacetic… Continue reading Synthesis of chiral R/S-pseudopeptide-based Cu(II) & Zn(II) complexes for use in targeted delivery for antitumor therapy: enantiomeric discrimination with CT-DNA and pBR322 DNA hydrolytic cleavage mechanism†

Structure and membrane interactions of the homodimeric antibiotic peptide homotarsinin

2017 / Scientific Reports

Antimicrobial peptides (AMPs) from amphibian skin are valuable template structures to find new treatments against bacterial infections. This work describes… Continue reading Structure and membrane interactions of the homodimeric antibiotic peptide homotarsinin

Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties

2017 / European Journal of Medicinal Chemistry

The DAPI structure has been modified by replacing the phenyl group with substituted phenyl or heteroaryl rings. Twelve amidines were… Continue reading Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties

Directing the self-assembly behaviour of porphyrin-based supramolecular systems

2017 / Chemistry A European Journal

The self-assembly behaviour of a library of tetra-amidated porphyrin molecules decorated with a variety of solubilizing wedges is investigated as… Continue reading Directing the self-assembly behaviour of porphyrin-based supramolecular systems

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Exploring the interaction of phenothiazinium dyes methylene blue, new methylene blue, azure A and azure B with tRNAPhe : Spectroscopic, thermodynamic, voltammetric and molecular modeling approach

Self-Directing Chiral Information in Solid-Solid Transformation: Unusual Chiral-Transfer without Racemization from Amorphous Silica to Crystalline Silicon

Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains

Anti-neuroinflammatory asarone derivatives from the rhizomes of Acorus tatarinowii

Circularly polarized luminescence based chirality transfer of the chiral BINOL moiety viarigid π-conjugation chain backbone structures

Understanding the Molecular Basis for Multiple Mitochondrial Dysfunctions Syndrome 1 (MMDS1) – Impact of a Disease-Causing Gly208Cys Substitution on Structure and Activity of NFU1 in the Fe/S Cluster Biosynthetic Pathway

Peptidic β-sheets induce Congo red-derived fluorescence to improve the sensitivity of HIV-1 p24 detection

Surface shear viscosity as a macroscopic probe of amyloid fibril formation at a fluid interface

Human Gpn1 purified from bacteria binds guanine nucleotides and hydrolyzes GTP as a protein dimer stabilized by its C-terminal tail

Cu2+ recognition by N,N′-benzylated bis(amino amides)

Conformational and functional transitions and in silico analysis of a serine protease from Conidiobolus brefeldianus (MTCC 5185)

Antimicrobial effects of novel peptides cOT2 and sOT2 derived from Crocodylus siamensis and Pelodiscus sinensis ovotransferrins

Probing the excitonic landscape of the Chlorobaculum tepidum Fenna-Matthews-Olson (FMO) complex: a mutagenesis approach

SDS induced dissociation of STY3178 oligomer: experimental and molecular dynamics studies

Revealing the Effect of Protein Weak Adsorption to Nanoparticles on the Interaction between the Desorbed Protein and its Binding Partner by Surface-Enhanced Infrared Spectroelectrochemistry

Amyloid–β 1–42 aggregation initiates its cellular uptake and cytotoxicity

Synthesis of chiral R/S-pseudopeptide-based Cu(II) & Zn(II) complexes for use in targeted delivery for antitumor therapy: enantiomeric discrimination with CT-DNA and pBR322 DNA hydrolytic cleavage mechanism†

Structure and membrane interactions of the homodimeric antibiotic peptide homotarsinin

Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties

Directing the self-assembly behaviour of porphyrin-based supramolecular systems

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