KnowledgeBase Articles Archive

Temperature-Triggered Switchable Helix-Helix Inversion of Poly(phenylacetylene) Bearing l-Valine Ethyl Ester Pendants and Its Chiral Recognition Ability

2016 / Molecules

A phenylacetylene containing the l-valine ethyl ester pendant (PAA-Val) was synthesized and polymerized by an organorhodium catalyst (Rh(nbd)BPh4) to produce the… Continue reading Temperature-Triggered Switchable Helix-Helix Inversion of Poly(phenylacetylene) Bearing l-Valine Ethyl Ester Pendants and Its Chiral Recognition Ability

Biophysical Evidence for Intrinsic Disorder in the C-terminal Tails of the EGFR and HER3 Receptor Tyrosine Kinases

2016 / The Journal of Biological Chemistry

The EGFR/ErbB family of receptor tyrosine kinases includes oncogenes important in the progression of breast and other cancers and they… Continue reading Biophysical Evidence for Intrinsic Disorder in the C-terminal Tails of the EGFR and HER3 Receptor Tyrosine Kinases

Binding properties of the natural red dye carthamin with human serum albumin: Surface plasmon resonance, isothermal titration microcalorimetry, and molecular docking analysis

2016 / Food Chemistry

The interaction between carthamin and human serum albumin (HSA) was investigated by multiple spectroscopic analyses, surface plasmon resonance (SPR), isothermal… Continue reading Binding properties of the natural red dye carthamin with human serum albumin: Surface plasmon resonance, isothermal titration microcalorimetry, and molecular docking analysis

Synthesis, characterization and serum albumin binding studies of vitamin K3 derivatives

2017 / Journal of Photochemistry and Photobiology B: Biology

Synthesis, characterization and bovine serum albumin (BSA) binding properties of three derivatives of vitamin K3 have been described. Results of… Continue reading Synthesis, characterization and serum albumin binding studies of vitamin K3 derivatives

Effect of peptide self-assembly on the rheological properties of alginate-peptide conjugates solutions

2016 / Polymer

Alginate, a polysaccharide that gels in the presence of divalent ions is an obvious component of an injectable gel for… Continue reading Effect of peptide self-assembly on the rheological properties of alginate-peptide conjugates solutions

Targeted delivery system for cancer cells consist of multiple ligands conjugated genetically modified CCMV capsid on doxorubicin GNPs complex

2016 / Scientific Reports

Targeted nano-delivery vehicles were developed from genetically modified Cowpea chlorotic mottle virus (CCMV) capsid by ligands bioconjugation for efficient drug delivery in… Continue reading Targeted delivery system for cancer cells consist of multiple ligands conjugated genetically modified CCMV capsid on doxorubicin GNPs complex

Data on the role of accessible surface area on osmolytes-induced protein stabilization

2016 / Data in Brief

This paper describes data related to the research article “Testing the dependence of stabilizing effect of osmolytes on the fractional… Continue reading Data on the role of accessible surface area on osmolytes-induced protein stabilization

Testing the dependence of stabilizing effect of osmolytes on the fractional increase in the accessible surface area on thermal and chemical denaturations of proteins

2016 / Archives of Biochemistry and Biophysics

Here we have generated two different denatured states using heat- and guanidinium chloride (GdmCl) – induced denaturations of three disulfide… Continue reading Testing the dependence of stabilizing effect of osmolytes on the fractional increase in the accessible surface area on thermal and chemical denaturations of proteins

Spectroscopic study on the binding of chelerythrine with duplex poly (rA): A model of RNA intercalation

2017 / International Journal of Biological Macromolecules

Here we have reported a detail study on the interaction of the benzophenanthridine alkaloid chelerythrine (CHL) with double stranded polyriboadenylic… Continue reading Spectroscopic study on the binding of chelerythrine with duplex poly (rA): A model of RNA intercalation

HRI, a stress response eIF2α kinase, exhibits structural and functional stability at high temperature and alkaline conditions

2016 / International Journal of Biological Macromolecules

The Heme Regulated Inhibitor (HRI) is a key regulator of protein synthesis in mammalian cells. Once activated under heme-deficiency and… Continue reading HRI, a stress response eIF2α kinase, exhibits structural and functional stability at high temperature and alkaline conditions

Envisaging Structural Insight of a Terminally Protected Proline Dipeptide by Raman Spectroscopy and DFT Analyses

2016 / Journal of Physical Chemistry A

The proline residue in a protein sequence generates constrains to its secondary structure as the associated torsion angles become a… Continue reading Envisaging Structural Insight of a Terminally Protected Proline Dipeptide by Raman Spectroscopy and DFT Analyses

Production and characterization of genetically modified human IL-11 variants

2017 / Biochimica et Biophysica Acta (BBA) - General Subjects

Interleukin-11 (IL-11) has been expected as a drug on severe thrombocytopenia caused by myelo-suppressive chemotherapy. Whereas, development of IL-11 inhibitor… Continue reading Production and characterization of genetically modified human IL-11 variants

Effect of lipid environment on amyloid fibril formation of human serum amyloid A

2017 / Chemistry and Physics of Lipids

Human serum amyloid A (SAA) is a precursor protein of AA amyloidosis and a component of high-density lipoproteins (HDLs), thus… Continue reading Effect of lipid environment on amyloid fibril formation of human serum amyloid A

Identification, characterization, and stabilization of the deamidation degradation of recombinant human tumor necrosis factor-α

2016 / Process Biochemistry

A kind of degradation characterized by an increase in overall negative charge in both native polyacrylamide gel electrophoresis analysis and… Continue reading Identification, characterization, and stabilization of the deamidation degradation of recombinant human tumor necrosis factor-α

A Dinuclear Mercury(II)-Mediated Base Pair in DNA

2016 / Angewandte Chemie

The first dinuclear metal-mediated base pair containing divalent metal ions has been prepared. A combination of the neutral bis(monodentate) purine… Continue reading A Dinuclear Mercury(II)-Mediated Base Pair in DNA

Observation of a Dynamic G-Tetrad Flip in Intramolecular G-Quadruplexes

2016 / Biochemistry

A MYC sequence forming an intramolecular G-quadruplex with a parallel topology was modified by the incorporation of 8-bromoguanosine (BrG) analogs in one… Continue reading Observation of a Dynamic G-Tetrad Flip in Intramolecular G-Quadruplexes

Identification of protein secondary structures by laser induced autofluorescence: A study of urea and GnHCl induced protein denaturation

2017 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

In the present study an attempt has been made to interrogate the bulk secondary structures of some selected proteins (BSA,… Continue reading Identification of protein secondary structures by laser induced autofluorescence: A study of urea and GnHCl induced protein denaturation

Photo Racemization and Polymerization of (R)-1,1′-Bi(2-naphthol)

2016 / Molecules

(R)-1,1’-Bi(2-naphthol) ((R)-BINOL) in an acetonitrile solution lost optical activity upon irradiation with an Hg–Xe lamp. HPLC resolution of the product… Continue reading Photo Racemization and Polymerization of (R)-1,1′-Bi(2-naphthol)

A pleckstrin homology-like domain is critical for F-actin binding and cofilin-phosphatase activity of Slingshot-1

2016 / Biochemical and Biophysical Research Communications

Slingshot-1 (SSH1) is a protein phosphatase that specifically dephosphorylates and activates cofilin, an F-actin-severing protein. SSH1 binds to and co-localizes… Continue reading A pleckstrin homology-like domain is critical for F-actin binding and cofilin-phosphatase activity of Slingshot-1

Heterologous Expression and Functional Characterization of Phytaspase, a Caspase-Like Plant Protease