Found 9617 Results / Page 369 of 481
2016 / Journal of Molecular Biology
The stem cell factor (SCF)/c-Kit receptor tyrosine kinase complex – with its significant roles in hematopoiesis and angiogenesis – is… Continue reading Identifying residues that determine SCF molecular-level interactions through a combination of experimental and in silicoanalyses
2016 / Biochimica et Biophysica Acta (BBA) - Biomembranes
Antimicrobial peptides (AMPs) are promising candidates for new antibiotic classes but often display an unacceptably high toxicity towards human cells.… Continue reading PGLa-H tandem-repeat peptides active against multidrug resistant clinical bacterial isolates
2016 / Colloids and Surfaces B: Biointerfaces
Herein we describe an interfacial local drug delivery system for bone morphogenetic protein 2 (BMP-2) based on coatings of polyelectrolyte… Continue reading Colloid, adhesive and release properties of nanoparticular ternary complexes between cationic and anionic polysaccharides and basic proteins like bone morphogenetic protein BMP-2
2016 / Dyes and Pigments
Two novel imidazopyridinium cations formed by a hexacyclic azonia aromatic system have been synthesized. Spectrofluorimetric titrations, circular dichroism measurements, theoretical… Continue reading Imidazopyridinium cations: A new family of azonia aromatic heterocycles with applications as DNA intercalators
2016 / Dyes and Pigments
A new chiral tetraphenylethene derivative with two l-leucine-containing attachments, TPE-DLEU, has been designed and synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition “click” reaction.… Continue reading Circularly polarized luminescence and controllable helical self-assembly of an aggregation-induced emission luminogen
2016 / European Journal of Medicinal Chemistry
Antimicrobial peptides are biologically active molecules produced by a wide range of organisms as an essential component of the innate… Continue reading Novel designed VmCT1 analogs with increased antimicrobial activity
2016 / Journal of Pharmaceutical and Biomedical Analysis
Currently prostate specific antigen (PSA) serum concentration is the most used prostate cancer marker, but it only shows limited specificity.… Continue reading Sample preparation of serum to allow capillary electrophoresis analysis of prostate specific antigen isoforms
2016 / Materials Science and Engineering: C
The healing of chronic wounds remains a key challenge in regenerative medicine. To promote wound healing, a bioactive wound dressing… Continue reading Functionalized silk fibroin dressing with topical bioactive insulin release for accelerated chronic wound healing
2016 / Journal of Pharmaceutical Sciences
It was recently reported that dropping induces protein aggregation due to the occurrence of cavitation. Agitation also causes protein aggregation.… Continue reading Synergistic Effect of Cavitation and Agitation on Protein Aggregation
2016 / Molecules
The partitioned n-hexane, CHCl3, and EtOAc extracts from the crude MeOH extract of Phaius mishmensisshowed considerable cytotoxicities against the human breast carcinoma… Continue reading Chemical Constituents of Phaius mishmensis
2016 / The Journal of Biological Chemistry
Elucidating molecular mechanisms of host-parasite interaction during red cell invasion by Plasmodium is important to develop newer antimalarial therapeutics. Recently,… Continue reading Basigin interacts with Plasmodium vivax tryptophan-rich antigen PvTRAg38 as a second erythrocyte receptor to promote parasite growth
2016 / Nature Communications
Little is known about how archaeal viruses perturb the transcription machinery of their hosts. Here we provide the first example… Continue reading Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP
2016 / Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Ixr1 is a transcriptional factor involved in the response to hypoxia, which is also related to DNA repair. It binds… Continue reading Dual function of Ixr1 in transcriptional regulation and recognition of cisplatin-DNA adducts is caused by differential binding through its two HMG-boxes
2016 / Fitoterapia
Five rare dichloro aromatic polyketides (1–5) were obtained from an endophytic fungus Penicillium sp., along with five known metabolites (6–10). Their structures… Continue reading Antimicrobial metabolites from the plant endophytic fungus Penicillium sp.
2016 / International Journal of Biological Macromolecules
WhmD is considered to have a role in the septation and division Mycobacterium smegmatis cells. Since FtsZ is the central protein of… Continue reading WhmD promotes the assembly of Mycobacterium smegmatisFtsZ: A possible role of WhmD in bacterial cell division
2016 / Biochimica et Biophysica Acta (BBA) - General Subjects
G-quadruplex (G4) are found at important genome regions such as telomere ends and oncogene promoters. One prominent strategy to explore… Continue reading Phenanthroline-bis-oxazole ligands for binding and stabilization of G-quadruplexes
2016 / Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
The Oct4 gene codes for a transcription factor that plays a critical role in the maintenance of pluripotency in embryonic… Continue reading G-quadruplex formation in the Oct4 promoter positively regulates Oct4 expression
2017 / International Journal of Biological Macromolecules
A multispectroscopic exploration was employed to investigate the interaction between the metallo-enzyme alcohol dehydrogenase (ADH) from yeast with bioflavonoid quercetin… Continue reading Inhibitory effects of the dietary flavonoid quercetin on the enzyme activity of zinc(II)-dependent yeast alcohol dehydrogenase: Spectroscopic and molecular docking studies
2013 / Langmuir
The effect of cationic liposomes (CLs) on messenger RNA(mRNA) conformation and translation was studied, focusing on membrane heterogeneity. CLs, composed… Continue reading Heterogeneous Cationic Liposomes Modified with 3β-{N-[(N′,N′-Dimethylamino)ethyl]carbamoyl}cholesterol Can Induce Partial Conformational Changes in Messenger RNA and Regulate Translation in an Escherichia coli Cell-Free Translation System
2013 / The Journal of Biological Chemistry
The Hsp100 chaperones ClpB and Hsp104 utilize the energy from ATP hydrolysis to reactivate aggregated proteins in concert with the… Continue reading The Molecular Mechanism of Hsp100 Chaperone Inhibition by the Prion Curing Agent Guanidinium Chloride
