Found 9617 Results / Page 381 of 481
2016 / Biopolymers
G-rich sequences can adopt four-stranded helical structures, called G-quadruplexes, that self-assemble around monovalent cations like sodium (Na+) and potassium (K+).… Continue reading A Parallel Stranded G-Quadruplex Composed of Threose Nucleic Acid (TNA)
2016 / Small
The oligomerization and aggregation of amyloid β (Aβ) play central role in the pathogenesis of Alzheimer’s disease (AD). Molecular binding… Continue reading Antiamyloidogenic Activity of Aβ42-Binding Peptoid in Modulating Amyloid Oligomerization
2016 / Scientific Reports
Hydrogen sulfide is an essential catabolite that intervenes in the pathophysiology of several diseases from hypertension to stroke, diabetes and… Continue reading Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production
2016 / Scientific Reports
The most widespread Plasmodium species, Plasmodium vivax, poses a significant public health threat. An effective vaccine is needed to reduce global malaria burden.… Continue reading A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119
2016 / The Journal of Biological Chemistry
Mammalian cytochrome c (Cytc) plays a key role in cellular life and death decisions, functioning as an electron carrier in… Continue reading Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: Implications for AMP Kinase
2016 / Scientific Reports
The present study reported for the first time covalent immobilization of protocatechuate 3,4-dioxygenase (3,4-POD) onto functionalized multi-walled carbon nanotubes (F-MWCNT)… Continue reading Highly Efficient and Stable Novel NanoBiohybrid Catalyst to Avert 3,4-Dihydroxybenzoic Acid Pollutant in Water
2016 / Amino Acids
Antimicrobial peptides (AMPs) play a key role in the defence mechanism of living organisms against microbial pathogens, displaying both bactericidal… Continue reading Effects of Aib residues insertion on the structural–functional properties of the frog skin-derived peptide esculentin-1a(1–21)NH2
2017 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
The giant sarcomere protein titin is the third filament in muscle and is integral to maintaining sarcomere integrity as well… Continue reading The insertion sequence of the N2A region of titin exists in an extended structure with helical characteristics
2017 / International Journal of Biological Macromolecules
Studying amyloid associated neurodegenerative diseases is an active area of research. Cure for these diseases are still to be discovered.… Continue reading Fibrillogenesis of human serum albumin in the presence of levodopa – spectroscopic, calorimetric and microscopic studies
2016 / Journal of Controlled Release
Nanoparticle delivery systems have been extensively investigated for targeted delivery of anticancer drugs over the past decades. However, it is… Continue reading Self-assembled mirror DNA nanostructures for tumor-specific delivery of anticancer drugs
2016 / Biophysical Chemistry
Light chain amyloidosis (AL) originates from the deposition of immunoglobulin light chains (LCs) as amyloid fibrils in the extracellular space… Continue reading Effects of oxidative post-translational modifications on structural stability and self-assembly of λ6 immunoglobulin light chain
2016 / Journal of Inorganic Biochemistry
Matrix metalloproteinase 7 (MMP7/matrilysin-1) has been implicated in many pathological conditions, such as in cancer and inflammatory diseases; therefore, MMP7… Continue reading Biochemical characterization and zinc binding group (ZBGs) inhibition studies on the catalytic domain of MMP7 (cdMMP7)
2016 / Biophysical Journal
Proteins are often functionally dependent on conformational changes that allow them to sample structural states that are sparsely populated in… Continue reading Urea-Dependent Adenylate Kinase Activation following Redistribution of Structural States
2016 / Biomacromolecules
We report the synthesis, spectroscopy, and the DNA binding properties of a biocompatible, water-soluble, polycationic two-photon absorbing anthracenyl derivative (Ant-PIm)… Continue reading Unravelling the binding mechanism of a poly(cationic) anthracenyl fluorescent probe with high affinity towards ds-DNA
2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Light-dependent protochlorophyllide oxidoreductase (POR, E.C. 1.3.1.33) is a plant enzyme that directly needs light to conduct a biochemical reaction. In… Continue reading Insight into the oligomeric structure of PORA from A. thaliana
2016 / Food Hydrocolloids
Whey proteins can form different types of gels depending on the method used for their preparation. The purpose of this… Continue reading Whey protein gelation induced by enzymatic hydrolysis and heat treatment: Comparison of creep and recovery behavior
2016 / Journal of Luminescence
Ellagic acid (EA) has been gaining a considerable attention in recent years. The interest in non-drug and herbal base therapies… Continue reading Counteraction of the deleterious effects of reactive oxygen species on hemoglobin structure and function by ellagic acid
2016 / Journal of Molecular Biology
Protein–protein interactions (PPIs) are increasingly important targets for drug discovery. Efficient fragment-based drug discovery approaches to tackle PPIs are often… Continue reading Engineering archeal surrogate systems for the development of protein–protein interaction inhibitors against human RAD51
2016 / Biochemical Engineering Journal
An efficient preparation process for a novel Enterovirus 71 (EV71) vaccine was developed in this paper, which is a fused… Continue reading Purification and assembling a fused capsid protein as an enterovirus 71 vaccine candidate from inclusion bodies to pentamer-based nanoparticles
2016 / Colloids and Surfaces B: Biointerfaces
Sup35 is a prion-like protein from yeast and shares the ability to transmit its aberrant fold and to aggregate into… Continue reading Amyloid formation characteristics of GNNQQNY from yeast prion protein Sup35 and its seeding with heterogeneous polypeptides
