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Found 9617 Results / Page 383 of 481

Hydrophilic Residues 526KNDAAD531 in the Flexible C-terminal Region of the Chaperonin GroEL Are Critical for Substrate Protein Folding within the Central Cavity

2008 / The Journal of Biological Chemistry

The final 23 residues in the C-terminal region of Escherichia coli GroEL are invisible in crystallographic analyses due to high flexibility. To… Continue reading Hydrophilic Residues 526KNDAAD531 in the Flexible C-terminal Region of the Chaperonin GroEL Are Critical for Substrate Protein Folding within the Central Cavity

Leah Pandiscia, PhD July 28, 2017

Biophysical characterization of highly active recombinantGaussia luciferase expressed in Escherichia coli

2010 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Recently, the smallest bioluminescent protein (MW: 19.9 kDa), Gaussia luciferase (GLuc), has been isolated from the marine copepod Gaussia princeps and has attracted much attention… Continue reading Biophysical characterization of highly active recombinantGaussia luciferase expressed in Escherichia coli

Leah Pandiscia, PhD July 28, 2017

Mechanistic insight of photo-induced aggregation of chicken egg white lysozyme: The interplay between hydrophobic interactions and formation of intermolecular disulfide bonds

2011 / Proteins: Structure, Function, and Bioinformatics

Recently, it was reported that ultraviolet (UV) illumination could trigger the unfolding of proteins by disrupting the buried disulfide bonds.… Continue reading Mechanistic insight of photo-induced aggregation of chicken egg white lysozyme: The interplay between hydrophobic interactions and formation of intermolecular disulfide bonds

Leah Pandiscia, PhD July 28, 2017

Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen

2016 / Nucleic Acids Research

Reported here is a laboratory in vitro evolution (LIVE) experiment based on an artificially expanded genetic information system (AEGIS). This experiment delivers… Continue reading Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen

Leah Pandiscia, PhD July 28, 2017

The effect of l-thymidine, acyclic thymine and 8-bromoguanine on the stability of model G-quadruplex structures

2016 / Biochimica et Biophysica Acta (BBA) - General Subjects

Guanine-rich oligonucleotides are capable of forming tetrahelical structures known as G-quadruplexes with interesting biological properties. We have investigated the effects… Continue reading The effect of l-thymidine, acyclic thymine and 8-bromoguanine on the stability of model G-quadruplex structures

Leah Pandiscia, PhD July 28, 2017

Molecular Recognition of tRNA with 1-Naphthyl Acetyl Spermine, Spermine and Spermidine: A Thermodynamic, Biophysical and Molecular Docking Investigative Approach

2016 / Journal of Physical Chemistry B

A major thrust of anticancer therapeutics is the dynamic quest for small molecules that binds and modifies nucleic acids and… Continue reading Molecular Recognition of tRNA with 1-Naphthyl Acetyl Spermine, Spermine and Spermidine: A Thermodynamic, Biophysical and Molecular Docking Investigative Approach

Leah Pandiscia, PhD July 28, 2017

Anti-angiogenesis through noninvasive to minimally invasive intraocular delivery of the peptide CC12 identified by in vivo-directed evolution

2016 / Biomaterials

Anti-vascular endothelial growth factor (VEGF) therapies are widely used for the treatment of neovascular fundus diseases such as diabetic retinopathy.… Continue reading Anti-angiogenesis through noninvasive to minimally invasive intraocular delivery of the peptide CC12 identified by in vivo-directed evolution

Leah Pandiscia, PhD July 28, 2017

Bioprocess for the production of recombinant HAP phytase of the thermophilic mold Sporotrichum thermophile and its structural and biochemical characteristics

2017 / International Journal of Biological Macromolecules

Thermophilc mold Sporotrichum thermophile secretes an acidstable and thermostable phytase, which finds application as a food and feed additive because of its… Continue reading Bioprocess for the production of recombinant HAP phytase of the thermophilic mold Sporotrichum thermophile and its structural and biochemical characteristics

Leah Pandiscia, PhD July 28, 2017

New copper(I) complexes bearing lomefloxacin motif: Spectroscopic properties, in vitro cytotoxicity and interactions with DNA and human serum albumin

2016 / Journal of Inorganic Biochemistry

In this paper we present lomefloxacin’s (HLm, 2nd generation fluoroquinolone antibiotic agent) organic and inorganic derivatives: aminomethyl(diphenyl)phosphine (PLm), its oxide… Continue reading New copper(I) complexes bearing lomefloxacin motif: Spectroscopic properties, in vitro cytotoxicity and interactions with DNA and human serum albumin

Leah Pandiscia, PhD July 28, 2017

Comparative study on the interaction of two binuclear Pt (II) complexes with human serum albumin: Spectroscopic and docking simulation assessments

2016 / Journal of Photochemistry and Photobiology B: Biology

Human serum albumin (HSA) principally tasks as a transport carrier for a vast variety of natural compounds and pharmaceutical drugs.… Continue reading Comparative study on the interaction of two binuclear Pt (II) complexes with human serum albumin: Spectroscopic and docking simulation assessments

Leah Pandiscia, PhD July 28, 2017
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