Found 9617 Results / Page 384 of 481
2016 / Process Biochemistry
PEGylation has successfully improved the pharmacological properties of therapeutic proteins. However, polyethylene glycol (PEG) has been burdened by immunogenicity that… Continue reading Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins
2016 / Tetrahedron
Toonasinemines A-K (1–12), twelve new azadirone- and gedunin-type limonoids with eight-classes of modified furan rings, were isolated from the root… Continue reading Limonoids with modified furan rings from root barks of Toona sinensis
2016 / Biochimie
Septins are GTP-binding proteins that are highly conserved among eukaryotes and which are usually membrane-associated. They have been linked to… Continue reading Biophysical dissection of schistosome septins: insights into oligomerization and membrane binding
2016 / Analytical and Bioanalytical Chemistry
Here, we for the first time demonstrated thioflavin T (ThT) as an efficient fluorescent ligand for 27-mer ATP-binding aptamer (ABA27),… Continue reading Thioflavin T behaves as an efficient fluorescent ligand for label-free ATP aptasensor
2016 / Scientific Reports
Dragline silk is the most prominent amongst spider silks and comprises two types of major ampullate spidroins (MaSp) differing in… Continue reading Acidic Residues Control the Dimerization of the N-terminal Domain of Black Widow Spiders’ Major Ampullate Spidroin 1
2016 / Chemical and Pharmaceutical Bulletin
From the stems of Croton cascarilloides, further crotofolane-type diterpenoids, named crotocascarins L–Q (1–6), and a rearranged one (7), named neocrotocascarin were… Continue reading Crotofolane-Type Diterpenoids, Crotocascarins L–Q, and a Rearranged Crotofolane-Type Diterpenoid, Neocrotocascarin, from the Stems of Croton cascarilloides
2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
The antiangiogenic and antitumor activities of the 27-amino acid fragment corresponding to the N-terminal domain of endostatin were shown to… Continue reading The antiangiogenic and antitumor activities of the N-terminal fragment of endostatin augmented by Ile/Arg substitution: The overall structure implicated the biological activity
2016 / Analytical Methods
Although protein structure has been studied for many decades it remains the case that we cannot state with confidence whether… Continue reading Biophysical characterization of a protein for structure comparison: methods for identifying insulin structural changes
2016 / RSC Advances
Eight closely biogenetically-related aromadendrane-type sesquiterpenoids, six of them new, scedogiines A–F (1–3, 6–8), together with a new polyketide scedogiine G (9)… Continue reading Discovery of aromadendrane anologues from the marine-derived fungus Scedosporium dehoogiiF41-4 by NMR-guided isolation
2016 / Physical Chemistry Chemical Physics
Prefibrillar amyloid aggregates of proteins are known as cytotoxic species and a common pathogenic factor of many degenerative diseases. The… Continue reading Formation of Lamellar Micelle-like Oligomers and Membrane Disruption Revealed by the Study of Short Peptide hIAPP18-27
2013 / BioMed Research International
The emergence of antibiotic resistance in microbial pathogens requires the identification of new antibacterial drugs. The biosynthesis of methionine is… Continue reading Characterization of C-S Lyase from C. diphtheriae: A Possible Target for New Antimicrobial Drugs
2014 / Proteins: Structure, Function, and Bioinformatics
In recent years, there has been increased interest in bacterial methionine biosynthesis enzymes as antimicrobial targets because of their pivotal… Continue reading Role of active-site residues Tyr55 and
Tyr114 in catalysis and substrate specificity
of Corynebacterium diphtheriae C-S lyase
2016 / International Journal of Biological Macromolecules
Microtubule affinity regulatory kinase 4 (MARK4) belongs to the family of AMP-activated protein kinase. It phosphorylates microtubule associated proteins at… Continue reading Ubiquitin-associated domain of MARK4 provides stability at physiological pH
2017 / Materials Science and Engineering: C
A transition of amyloidogenic protein by alternative folding pathway under certain conditions leads to the formation of protease resistant amyloid… Continue reading In vitro and in vivo insulin amyloid degradation mediated by Serratiopeptidase
2016 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Imatinib mesylate (Imt) is a tyrosine kinase inhibitor mainly used in the treatment of Philadelphia chromosome-positive chronic myelogenous leukemia (pH + CML).… Continue reading Interaction of imatinib mesylate with human serum transferrin: The comparative spectroscopic studies
2016 / Inorganic Chemistry Communications
DNA damage by endogenous/exogenous chemicals and ionizing radiation results in the formation of abasic sites, alkylation products, oxidative lesions and… Continue reading Effect of conformation of the Arylamine-DNA adduct on the sensitivity of [Ru(phen)2(dppz)]2 + complex
2017 / Journal of Molecular Structure
The interaction of Deltamethrin (DM) with human serum albumin (HSA) under the condition of simulating human blood pH environment (pH = 7.4)… Continue reading Investigation of the interaction of deltamethrin (DM) with human serum albumin by multi-spectroscopic method
2016 / Journal of Molecular Biology
Armadillo repeat proteins (ArmRP) recognize their target peptide in extended conformation and bind, in a first approximation, two residues per… Continue reading Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition
2016 / Journal of Photochemistry and Photobiology B: Biology
The present work demonstrates a detailed photophysics of bio-active drug-like acid viz., 2-hydroxynicotinic acid (2-HNA) and its interaction with a… Continue reading Effect of the binding interaction of an emissive niacin derivative on the conformation and activity of a model plasma protein: A spectroscopic and simulation-based approach
2016 / Process Biochemistry
Peptides play an important role in metabolic regulation. In this study, one primary peptide derived from ostrich egg white protein… Continue reading Bioactive and ACE binding properties of three synthetic peptides assessed by various spectroscopy techniques
