Found 9617 Results / Page 405 of 481
2016 / Journal of Biological Chemistry
The accumulation of Amyloid beta peptide1-42 (Aβ1-42) in extracellular plaques is one of the pathological hallmarks of Alzheimer’s disease (AD).… Continue reading Amyloid-β 1-42 Aggregation Initiates Its Cellular Uptake and Cytotoxicity
2016 / European Journal of Organic Chemistry
Four isomeric chiral 3-amino-β-lactams 4 with p-fluorophenyl and p-methoxyphenyl substituents at N and C-4 positions, similar to the cholesterol absorption inhibitor ezetimibe, have been… Continue reading Synthesis, Separation and Absolute Configuration Determination by ECD Spectroscopy and TDDFT Calculations of 3-Amino-β-lactams and Derived Guanidines
2016 / Journal of Nanobiotechnology
Amyloidoses are characterized by the extracellular deposition of insoluble fibrillar proteinaceous aggregates highly organized into cross-β structure and referred to… Continue reading Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting
2017 / Food Hydrocolloids
We have combined isothermal titration calorimetry (ITC), spectroscopy and small-angle X-ray scattering (SAXS) to describe the denaturation process of bovine… Continue reading α-Lactalbumin and sodium dodecyl sulfate aggregates: Denaturation, complex formation and time stability
2016 / Journal of Biomolecular Structure and Dynamics
In this study, molecular binding affinity was investigated for Nefopam analogues (NFs), a functionalized benzoxazocine, with human serum albumin (HSA),… Continue reading Unravelling the Binding Mechanism and Protein Stability of Human Serum Albumin while Interacting with Nefopam Analogues: A Biophysical and Insilco approach
2016 / Journal of Asia-Pacific Entomology
We identified vespid chemotactic peptide (VCP) and vespakinin (Vespk) from the lesser paper wasp, Parapolybia varia. The cDNA, genomic DNA, and… Continue reading Selective anti-tumor activities of venom peptides from the lesser paper wasp Parapolybia varia
2017 / Journal of Molecular Structure
Protein bound toxins are poorly removed by conventional extracorporeal therapies. Venous thromboembolism (VTE) is a major cause of morbidity and… Continue reading A spectroscopic and molecular docking approach on the binding of tinzaparin sodium with human serum albumin
2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Hemodialysis-associated amyloidosis (HAA) involves the fibrillization of β2-microglobulin (β2M) and occurs in crowded physiological environments. However, how macromolecular crowding affects… Continue reading Macromolecular crowding favors the fibrillization of β2-microglobulin by accelerating the nucleation step and inhibiting fibril disassembly
2016 / Food Chemistry
The salting-in effect on muscle protein is well-known in food science but hard to explain using conventional theories. Myofibrillar protein… Continue reading Salting-in Effect on Muscle Protein Extracted from Giant Squid (Dosidicus gigas)
2016 / Molecular and Biochemical Parasitology
The enteric protozoan parasite, Entamoeba histolytica, an etiological agent of amebiasis, is involved in the adhesion and destruction of human tissues. Worldwide,… Continue reading Role of cysteine residues in the redox-regulated oligomerization and nucleotide binding to EhRabX3
2016 / Polyhedron
A series of phosphorescent heteroleptic iridium(III) complexes containing two cyclometallating 6-chloro-2-(4-methoxyphenyl)-3-phenylquinoline (p-OMepq) ligands and one chromophoric ancillary ligand were synthesized… Continue reading Red Emitting Cyclometallated Iridium(III) Complexes: Synthesis, Characterization and Evaluation of Biological Activities
2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
HMGB1 triggers proinflammatory reactions by interacting extracellularly with various receptors. HMGB1 also acts in the nucleus by interacting with DNA… Continue reading The effect of physicochemical factors on the self-association of HMGB1: A surface plasmon resonance study
2016 / Tetrahedron
Hyperhexanones A (1) and B (2), two novel polycyclic polyprenylated acylphloroglucinol (PPAPs) derivatives, were isolated from Hypericum sampsonii. Compound 1 possesses a novel… Continue reading Hyperhexanone A, a crucial intermediate from bicyclo[3.3.1]- to cyclohexanone monocyclic-polycyclic polyprenylated acylphloroglucinols
2016 / Journal of Inorganic Biochemistry
Six platinum(II) complexes of the type [Pt(PL)(AL)]2 +, where PL is a bidentate pyridyl-1,2,3-triazole “click” ligand and AL is the R,R or S,S isomer of 1.2-diaminocyclohexane, have… Continue reading Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole “click” ligands
2016 / Virology
Viral capsid proteins are programmed to assemble into homogeneous structures in native environments; but the molecular details of these assembly… Continue reading In vitro assembly of polymorphic virus-like particles from the capsid protein of a nodavirus
2016 / Biochimica et Biophysica Acta (BBA) - Biomembranes
Reconstituted membranes with diverse diacylphospholipids were prepared by using bacteriorhodopsin (bR) in which the intrinsic lipid content was decreased to… Continue reading Evaluation of Diacylphospholipids as Boundary Lipids for Bacteriorhodopsin from Structural and Functional Aspects
2016 / European Journal of Medicinal Chemistry
An efficient synthesis of fatty acid derivatives of 1,3,4-oxadiazole has been reported and comparative study between conventional heating to that… Continue reading Synthesis, characterization and interaction studies of 1,3,4-oxadiazole derivatives of fatty acid with human serum albumin (HSA): A combined multi-spectroscopic and molecular docking study
2016 / Journal of Controlled Release
Peptide based vaccine that incorporates one or several highly conserved CD8+ T cells epitopes to induce potent cytotoxic T lymphocyte… Continue reading Self-assembling peptide for co-delivery of HIV-1 CD8 + T cell epitope and toll-like receptor 7/8 agonists R848 to induce maturation of monocyte derived dendritic cell and augment polyfunctional cytotoxic T lymphocyte sCTL) response
2016 / Journal of Pharmaceutical Sciences
Shigella rely on a type III secretion system as the primary virulence factor for invasion and colonization of human hosts. Although… Continue reading Detergent Isolation Stabilizes and Activates the Shigella Type III Secretion System Translocator Protein IpaC
2016 / Materials Chemistry and Physics
Herein, we report a new wet-synthesis method to separate some water-soluble chiral silver nanoclusters with high yield. The cluster material… Continue reading Enantioselective silver nanoclusters: Preparation, characterization and photoluminescence spectroscopy
