N-terminal domain of PB1-F2 protein of influenza A virus can fold into amyloid-like oligomers and damage cholesterol and cardiolipid containing membranes

2016 / Biochemical and Biophysical Research Communications

PB1-F2 protein is a factor of virulence of influenza A viruses which increases the mortality and morbidity associated with infection. …

Leah Pandiscia, PhD

Investigation of folding unfolding process of a new variant of dihydrofolate reductase protein from Zebrafish

2016 / International Journal of Biological Macromolecules

The folding and unfolding mechanisms of a small monomeric protein, Dihydrofolate reductase (1.5.1.3.) from a new variant, Zebrafish (zDHFR) has been studied through GdnHCl …

Leah Pandiscia, PhD

Stereospecific interaction of optically active sulfur-bridged dinuclear Co(III)–Pt(II) complex with pseudo-enantiomeric Co(III)–M(II) (M: Pd or Pt) complex involving unequivalent π electronic system

2016 / Inorganica Chimica Acta

Assemblies between the pseudo-enantiomers with different π electronic systems, [Pt(bpy){Co(d-pen)2}]+ (bpy = 2,2′-bipyridine, pen = penicillaminate) and [M(phen){Co(l-pen)2}]+ (M = Pt or Pd, phen = 1,10-phenanthroline), or [Pt(bpy){Co(l-pen)2}]+ and [M(phen){Co(d-pen)2}]+, have …

Leah Pandiscia, PhD

Simple NMR methods for evaluating higher order structures of monoclonal antibody therapeutics with quinary structure

2016 / Journal of Pharmaceutical and Biomedical Analysis

Monoclonal antibody (mAb) drugs constitute the largest class of protein therapeutics currently on the market. Correctly folded protein higher order …

Leah Pandiscia, PhD

Biophysical insights into the membrane interaction of the core amyloid-forming Aβ40 fragment K16–K28 and its role in the pathogenesis of Alzheimer’s disease

2016 / Physical Chemistry Chemical Physics

The aggregation of amyloid-β (Aβ) on neuronal membranes is implicated in both neuronal toxicity and the progression of Alzheimer’s disease. …

Leah Pandiscia, PhD

Histidine switch controlling pH-dependent protein folding and DNA binding in a transcription factor at the core of synthetic network devices

2016 / Molecular BioSystems

Therapeutic strategies have been reported that depend on synthetic network devices in which a urate-sensing transcriptional regulator detects pathological levels …

Leah Pandiscia, PhD

Simultaneous presence of dynamic and sphere action component in the fluorescence quenching of human serum albumin by diphthaloylmaslinic acid

2016 / Journal of Luminescence

The fluorescence quenching of human serum albumin (HSA) by diphthaloylmaslinic acid (FMA) at different pH and temperature values was investigated …

Leah Pandiscia, PhD

Biodegradable Thermal- and Redox-Responsive Poly(L-glutamate) with Y-shaped Oligo(ethylene glycol) Side-chain and Tunable Phase Transition Temperature

2016 / RSC Advances

A series of poly(L-glutamate) bearing Y-shaped oligo(ethylene glycol)x (OEGx) side-chains (PPLG-g-EGx, x = 2, 3 and 4) were synthesized via …

Leah Pandiscia, PhD

Isolation and chatacterization of homoisoflavonoids fromDracaena cochinchinensis and their osteogenic activities in mouse mesenchymal stem cells

2016 / Journal of Pharmaceutical and Biomedical Analysis

Two new homoisoflavonoids, dracaeconolide A (1) and dracaeconolide B (2), together with ten known compounds, namely (3R)-7,4′-dihydroxy-8-methoxyhomoisoflavane (3), (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane (4), …

Leah Pandiscia, PhD