Megastigmane glycosides from leaves of Eucommia ulmoidesOliver with ACE inhibitory activity

2017 / Fitoterapia

Four new megastigmane glycosides, eucomegastigsides A-D (2, 3, 5 and 7), together with three known megastigmane glycosides, (6R, 7E, 9R)-9-hydroxy-4, 7-megastigmadien-3-one-9-O-[α-l-arabinopyranosyl-(l → 6)-β-d-glucopyranoside (1), foliasalacioside B1 (4) and …

Leah Pandiscia, PhD

Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model

2016 / Scientific Reports

Aggregation of alpha synuclein (α-syn) leading to dopaminergic neuronal death has been recognized as one of the main pathogenic factors …

Leah Pandiscia, PhD

The p10 FAST protein fusion peptide functions as a cystine noose to induce cholesterol-dependent liposome fusion without liposome tubulation

2015 / Biochimica et Biophysica Acta (BBA) - Biomembranes

The reovirus p10 fusion-associated small transmembrane (FAST) proteins are the smallest known membrane fusion proteins, and evolved specifically to mediate …

Leah Pandiscia, PhD

Membrane-Dependent Conformation, Dynamics, and Lipid Interactions of the Fusion Peptide of the Paramyxovirus PIV5 from Solid-State NMR

2013 / Journal of Molecular Biology

The entry of enveloped viruses into cells requires protein-catalyzed fusion of the viral and cell membranes. The structure–function relation of …

Leah Pandiscia, PhD

Physicochemical characterization of GBV-C E1 peptides as potential inhibitors of HIV-1 fusion peptide: Interaction with model membranes

2012 / International Journal of Pharmaceutics

Four peptide sequences corresponding to the E1 protein of GBV-C: NCCAPEDIGFCLEGGCLV (P7), APEDIGFCLEGGCLVALG (P8), FCLEGGCLVALGCTICTD (P10) and QAGLAVRPGKSAAQLVGE (P18) were …

Leah Pandiscia, PhD

Structure–activity relationships of the antimicrobial peptide gramicidin S and its analogs: Aqueous solubility, self-association, conformation, antimicrobial activity and interaction with model lipid membranes

2014 / Biochimica et Biophysica Acta (BBA) - Biomembranes

GS10 [cyclo-(VKLdYPVKLdYP)] is a synthetic analog of the naturally occurring antimicrobial peptide gramicidin (GS) in which the two positively charged …

Leah Pandiscia, PhD

Structural characterisation, stability and antibody recognition of chimeric NHBA-GNA1030: An investigational vaccine component against Neisseria meningitidis

2012 / Vaccine

A new generation multi-component vaccine, principally directed against serogroup B Neisseria meningitidis (4CMenB), has recently been developed. One of its components, identified …

Leah Pandiscia, PhD