2023 / Communications Biology
Inhibition of amyloid-β peptide (Aβ) accumulation in the brain is a promising approach for treatment of Alzheimer’s disease (AD). Aβ… Continue reading A Tailored Tetravalent Peptide Displays Dual Functions to Inhibit Amyloid β Production and Aggregation
2023 / Scientific Reports
TDP-43 is a major pathological protein in sporadic and familial amyotrophic lateral sclerosis (ALS) and mediates mRNA fate. TDP-43 dysfunction… Continue reading ALS-Linked TDP-43 Mutations Interfere with the Recruitment of RNA Recognition Motifs to G-Quadruplex RNA
2023 / Nature Communications
In drug discovery, efficient screening of protein-drug interactions (PDIs) is hampered by the limitations of current biophysical approaches. Here, we… Continue reading Single-Molecule Fingerprinting of Protein-Drug Interaction Using a Funneled Biological Nanopore
2023 / Scientific Reports
Artificial phase-separating (PS) peptides can be used in various applications such as microreactors and drug delivery however, the design of… Continue reading Rational Design of Phase Separating Peptides Based on Phase Separating Protein Sequence of P53
2023 / Chemistry – A European Journal
Non-centrosymmetric spin switchable systems are of interest for their prospective applications as magnetically active non-linear optical materials and in multiferroic… Continue reading Spontaneous Chiral Resolution of a MnIII Spin Crossover Complex with High Temperature 80 K Hysteresis
2023 / Scientific Reports
Deposition of high-order protein oligomers is a common hallmark of a large number of human diseases and therefore, has been… Continue reading Functionally Active Cross-Linked Protein Oligomers Formed by Homocysteine Thiolactone
2023 / Nature Communications
Enzyme catalysis is used to generate approximately 50,000 tons of value-added chemical products per year. Nearly a quarter of this… Continue reading Bioelectrocatalysis with a Palladium Membrane Reactor
2023 / Advanced Healthcare Materials
Proteinaceous nanoparticles constitute efficient antigen delivery systems in vaccine formulations due to their size and repetitive nature that mimic most… Continue reading Engineered Curli Nanofilaments as a Self-Adjuvanted Antigen Delivery Platform
2023 / Npj Vaccines
Development of a malaria vaccine that blocks transmission of different parasite stages to humans and mosquitoes is considered critical for… Continue reading Structural and Immunological Differences in Plasmodium Falciparum Sexual Stage Transmission-Blocking Vaccines Comprised of Pfs25-EPA Nanoparticles
2023 / ChemBioChem
The type 2 secretion system (T2SS) is a bacterial nanomachine constituted by an inner membrane assembly platform, an outer membrane… Continue reading Refining the Dynamic Network of T2SS Endopilus Tip Hetero-Complex Combining Cw-EPR and Nitroxide-Gd(III) Distance Measurements
2023 / Nature Communications
Dynamin-like proteins are membrane remodeling GTPases with well-understood functions in eukaryotic cells. However, bacterial dynamin-like proteins are still poorly investigated.… Continue reading SynDLP Is a Dynamin-like Protein of Synechocystis Sp. PCC 6803 with Eukaryotic Features
2023 / Nature Communications
Our recent work has shown that DCAF1 (also known as VprBP) is overexpressed in colon cancer and phosphorylates histone H2AT120… Continue reading Phosphorylation and Stabilization of EZH2 by DCAF1/VprBP Trigger Aberrant Gene Silencing in Colon Cancer
2023 / Communications Biology
Uncultured microbes represent a huge untapped biological resource of novel genes and gene products. Although recent genomic and metagenomic sequencing… Continue reading New Carbohydrate Binding Domains Identified by Phage Display Based Functional Metagenomic Screens of Human Gut Microbiota
2023 / Nature Communications
Engrailed2 (En2) is a transcription factor that transfers from cell to cell through unconventional pathways. The poorly understood internalization mechanism… Continue reading A Cationic Motif Upstream Engrailed2 Homeodomain Controls Cell Internalization through Selective Interaction with Heparan Sulfates
2023 / Biotechnology and Bioengineering
Vaccine development against dengue virus is challenging because of the antibody-dependent enhancement of infection (ADE), which causes severe disease. Consecutive… Continue reading Mimotope Discovery as a Tool to Design a Vaccine against Zika and Dengue Viruses
2023 / Communications Biology
Mycobacterium tuberculosis Clp proteases are targeted by several antitubercular compounds, including cyclomarin A (CymA). CymA exerts its toxicity by binding… Continue reading ClpC2 Protects Mycobacteria against a Natural Antibiotic Targeting ClpC1-Dependent Protein Degradation
2023 / Advanced Materials
Self-assembled compartments from nanoscale components are found in all life forms. Their characteristic dimensions are in 50?1000 nm scale, typically assembled… Continue reading Self-Organization of Iron Sulfide Nanoparticles into Complex Multi-Compartment Supraparticles
2023 / Nature Communications
The fabrication of chiral molecules into macroscopic systems has many valuable applications, especially in the fields of optical displays, data… Continue reading Supramolecular Glasses with Color-Tunable Circularly Polarized Afterglow through Evaporation-Induced Self-Assembly of Chiral Metal–Organic Complexes
2023 / ChemBioChem
Although rarely used in nature, fluorine has emerged as an important elemental ingredient in the design of proteins with altered… Continue reading Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions
2023 / Small
Chiral transition metal oxide nanoparticles (CTMOs) are attracting a lot of attention due to their fascinating properties. Nevertheless, elucidating the chirality… Continue reading Histidine-Mediated Synthesis of Chiral Cobalt Oxide Nanoparticles for Enantiomeric Discrimination and Quantification
