A series of arene Ru(II) complexes coordinated with phenanthroimidazole derivatives, [(η6-C6H6)Ru(l)Cl]Cl(1b L = p-ClPIP = 2-(4-Chlorophenyl)imidazole[4,5f] 1,10-phenanthroline; 2b L = m-ClPIP = 2-(3-Chlorophenyl)imidazole[4,5f] 1,10-phenanthroline; 3b L = p-NPIP… Continue reading Microwave-Assisted Synthesis of Arene Ru(II) Complexes Induce Tumor Cell Apoptosis Through Selectively Binding and Stabilizing bcl-2 G-Quadruplex DNA
Leah Pandiscia, PhD
July 28, 2017
Six new compounds including one γ-butyrolactone, cinncassin A (1), two tetrahydrofuran derivatives, cinncassins B and C (2, 3), two lignans, cinncassins… Continue reading Nitric oxide inhibitory constituents from the barks of Cinnamomum cassia
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
DNA separation by fragment length can be readily achieved using sieving gels in electrophoresis. Separation by sequence has not been… Continue reading Sequence-Based separation of single-stranded dna at high salt concentrations in capillary zone electrophoresis
Leah Pandiscia, PhD
July 28, 2017
Botulinum neurotoxins (BoNTs) exhibit extraordinary potency due to their exquisite neurospecificity, which is achieved by dual binding to complex polysialo-gangliosides… Continue reading Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin
Leah Pandiscia, PhD
July 28, 2017
Recently there has been growing interest in the discovery of new antimicrobial agents to increase safety and shelf-life of food… Continue reading New antimicrobial peptides against foodborne pathogens: From in silico design to experimental evidence
Leah Pandiscia, PhD
July 28, 2017
The amount of heat-denatured whey protein is typically determined by pH 4.6 precipitation. Using this method, a significant amount of… Continue reading Controlling the Ratio between Native-Like, Non-Native-Like, and Aggregated β-Lactoglobulin after Heat Treatment
Leah Pandiscia, PhD
July 28, 2017
The interaction between nanoparticles (NPs) and proteins is a topic of high relevance for the medical application of NPs. This… Continue reading Influence of Albumin Configuration by the Chiral Polymer-Grafted Gold Nanoparticles
Leah Pandiscia, PhD
July 28, 2017
It remains challenging to develop methods that can precisely control the self-assembling kinetics and thermodynamics of peptide hydrogelators to achieve… Continue reading Peptide hydrogelation triggered by enzymatic induced pH switch
Leah Pandiscia, PhD
July 28, 2017
The authors describe an aptasensor for the detection of the gonadal hormone progesterone (P4) in aqueous solution. Gold nanoparticles (AuNPs)… Continue reading A label-free colorimetric progesterone aptasensor based on the aggregation of gold nanoparticles
Leah Pandiscia, PhD
July 28, 2017
Two new phenone derivatives penicophenones A (1) and B (2), a new cyclic tetrapeptide penicopeptide A (3), and five known… Continue reading Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
It has been shown that the membranotropic homeostatic tissue-specific bioregulator isolated from rat liver tissue contains a nanosized peptide-protein complex… Continue reading Bioregulator from rat liver tissue
Leah Pandiscia, PhD
July 28, 2017
This study reports purification and characterization of lipoxygenase protein from mung bean germinating seedlings. Lipoxygenases (LOXs) are key enzymes in… Continue reading Purification and characterization of lipoxygenase from mung bean (Vigna radiataL.) germinating seedlings
Leah Pandiscia, PhD
July 28, 2017
A convenient proline- and α-methylproline-mediated method for the synthesis of enantiomerically pure bis-cyclometalated iridium(III) complexes is reported. The reactions of l-proline… Continue reading Proline and α-Methylproline as Chiral Auxiliaries for the Synthesis of Enantiopure Bis-Cyclometalated Iridium(III) Complexes
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Four chiral Ru(II) complexes bearing furan ligands, Delta/Lamda-[Ru(bpy)2(pocl)]2+(Delta/Lamda-1) and Delta/Lamda-[Ru(bpy)2(poi)]2+ (Delta/Lamda-2) (bpy = 2,2’-bipyridine, pocl = 2-(5-chlorofuran-2-yl)imidazo[4,5-f][1,10]phenanthroline, poi = 2-(5-5-iodofuran-2-yl)imidazo[4,5-f][1,10]phenanthroline),… Continue reading Topoisomerase IIα poisoning and DNA double-stand breaking by chiral ruthenium(II) complexes containing 2-furanyl-imidazo[4,5-f][1,10]phenanthroline derivatives
Leah Pandiscia, PhD
July 28, 2017
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a ubiquitous enzyme involved in glycolysis. It is also referred to as a moonlighting protein as… Continue reading Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus
Leah Pandiscia, PhD
July 28, 2017
In this work, an effective dual-color fluorescent biosensing platform based on WS2nanosheets was developed for homogeneous detection of Hg2+ and Ag+.… Continue reading A dual-color fluorescent biosensing platform based on WS2nanosheet for detection of Hg2+ and Ag+
Leah Pandiscia, PhD
July 28, 2017
Redox-dependent switches of enzyme activity are emerging as important fine-tuning mechanisms in cell signaling. For example, protein tyrosine phosphatases employ… Continue reading Reversible oxidation controls the activity and oligomeric state of the mammalian phosphoglycolate phosphatase AUM
Leah Pandiscia, PhD
July 28, 2017
