A novel, rationally designed, hybrid antimicrobial peptide, inspired by cathelicidin and aurein, exhibits membrane-active mechanisms against Pseudomonas aeruginosa

2020 / Scientific Reports

Antimicrobial peptides (AMPs) are promising alternatives to classical antibiotics for the treatment of drug-resistant infections. Due to their versatility and… Continue reading A novel, rationally designed, hybrid antimicrobial peptide, inspired by cathelicidin and aurein, exhibits membrane-active mechanisms against Pseudomonas aeruginosa

Leah Pandiscia, PhD

Synergistic stabilization by nitrosoglutathione-induced thiol modifications in the stromal interaction molecule-2 luminal domain suppresses basal and store operated calcium entry

2020 / Scientific Reports

Stromal interaction molecule−1 and −2 (STIM1/2) are endoplasmic reticulum (ER) membrane-inserted calcium (Ca2+) sensing proteins that, together with Orai1-composed Ca2+ channels… Continue reading Synergistic stabilization by nitrosoglutathione-induced thiol modifications in the stromal interaction molecule-2 luminal domain suppresses basal and store operated calcium entry

Leah Pandiscia, PhD

Identification and Characterization of a Redox Sensor Phosphodiesterase from Ferrovum sp. PN-J185 Containing Bacterial Hemerythrin and HD-GYP Domains

2020 / Biochemistry

The second messenger bis(3′,5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) regulates numerous important physiological functions in bacteria. In this study, we identified… Continue reading Identification and Characterization of a Redox Sensor Phosphodiesterase from Ferrovum sp. PN-J185 Containing Bacterial Hemerythrin and HD-GYP Domains

Leah Pandiscia, PhD

Membrane pore-formation correlates with the hydrophilic angle of histidine-rich amphipathic peptides with multiple biological activities

2020 / Biochimica et Biophysica Acta (BBA) - Biomembranes

The LAH4 family of amphipathic peptides exhibits pronounced antimicrobial, cell penetrating and nucleic acid transfection activities. Furthermore, variants were designed… Continue reading Membrane pore-formation correlates with the hydrophilic angle of histidine-rich amphipathic peptides with multiple biological activities

Leah Pandiscia, PhD

Nonclassical dual control of circularly polarized luminescence modes of binaphthyl–pyrene organic fluorophores in fluidic and glassy media†

2014 / Chemical Communications

The fluorescent modes and signs of the circularly polarized luminescence of an axially chiral binaphthyl–pyrene organic fluorophore were successfully controlled… Continue reading Nonclassical dual control of circularly polarized luminescence modes of binaphthyl–pyrene organic fluorophores in fluidic and glassy media†

Leah Pandiscia, PhD