2023 / Advanced Healthcare Materials
Eradicating HIV/AIDS by 2030 is a central goal of the World Health Organization. Patient adherence to complicated dosage regimens remains… Continue reading Enzyme-Triggered L-α/D-Peptide Hydrogels as a Long-Acting Injectable Platform for Systemic Delivery of HIV/AIDS Drugs
2023 / Advanced Synthesis & Catalysis
Domino Knoevenagel-cyclization reactions of 2H-chromene and chroman derivatives containing o-formylaryl amine or ether side-chain was carried out to produce four… Continue reading Multifaceted Domino Knoevenagel-Cyclization Reactions; Four Movements for 2H-Chromenes and Chromans
2023 / Advanced Materials
The design of additives showing strong and selective interactions with certain target surfaces is key to crystallization control in applied… Continue reading Phage Display Screening as a Rational Approach to Design Additives for Selective Crystallization Control in Construction Systems
2020 / Chemical Physics Letters 758 (2020) 137935
Treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19, may well be predicated on knowledge… Continue reading Computed optical spectra of SARS-CoV-2 proteins
2021 / Scientific Reports (2021) 11:24471
Helicobacter pylori is a Gram-negative bacterium that causes chronic inflammations in the stomach area and is involved in ulcers, which… Continue reading Biophysical characterization of the homodimers of HomA and HomB, outer membrane proteins of Helicobacter pylori
2022 / Int. J. Mol. Sci. 2022, 23, 6914.
The Svx proteins are virulence factors of phytopathogenic bacteria of the Pectobacterium genus. The specific functions of these proteins are… Continue reading Structure-Functional Characteristics of the Svx Protein—The Virulence Factor of the Phytopathogenic Bacterium Pectobacterium atrosepticum
2022 / Pharmaceutics 2022, 14, 1921
Lacticaseicin 30 is one of the five bacteriocins produced by the Gram-positive Lacticaseibacillus paracasei CNCM I-5369. This 111 amino acid… Continue reading Structure of Lacticaseicin 30 and Its Engineered Variants Revealed an Interplay between the N-Terminal and C-Terminal Regions in the Activity against Gram-Negative Bacteria
2023 / Structural Biology Communications
Bornaviruses are RNA viruses with a mammalian, reptilian, and avian host range. The viruses infect neuronal cells and in rare… Continue reading Structural and biophysical characterization of the Borna disease virus 1 phosphoprotein
2023 / Chemistry A Europen Journal
We herein investigated chiroptical activities of pyrene clusters incorporated within a DNA duplex. Three pyrene derivatives were prepared on D-threoninol… Continue reading Orientational Control of Circularly Polarized Luminescence from Pyrene Clusters using a DNA Scaffold.
2023 / Angewandte Chemie
Inspired by biological helices (e.g., DNA), artificial helical polymers have attracted intense attention. However, precise synthesis of one-handed helices from… Continue reading Visible Helicity Induction and Memory in Polyallene toward Circularly Polarized Luminescence, Helicity Discrimination, and Enantiomer Separation
2022 / Nature Communications
Rhodobacter (Rba.) capsulatus has been a favored model for studies of all aspects of bacterial photosynthesis. This purple phototroph contains… Continue reading Rhodobacter capsulatus forms a compact crescent-shaped LH1–RC photocomplex
2022 / Nature Communications
The phenomenon of protein aggregation is associated with a wide range of human diseases. Our knowledge of the aggregation behaviour… Continue reading Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes
2023 / Nature
Thousands of genetic variants in protein-coding genes have been linked to disease. However, the functional impact of most variants is… Continue reading Aberrant phase separation and nucleolar dysfunction in rare genetic diseases
2022 / Communications Biology
Light chain (AL) amyloidosis is a debilitating disease in which mutant antibody light chains (LC), secreted by aberrant plasma cell… Continue reading A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis
2023 / Nature Communications
To better understand how amino acid sequence encodes protein structure, we engineered mutational pathways that connect three common folds (3α,… Continue reading Design and characterization of a protein fold switching network
2023 / Nature Communications
The RNA binding protein TDP-43 forms cytoplasmic inclusions via its C-terminal prion-like domain in several neurodegenerative diseases. Aberrant TDP-43 aggregation… Continue reading Metamorphism in TDP-43 prion-like domain determines chaperone recognition
2023 / Communications Biology
The SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 both anchored to the presynaptic membrane. It… Continue reading Mass spectrometry uncovers intermediates and off-pathway complexes for SNARE complex assembly
2023 / Advanced Science
Despite the promising advancements of in situ forming nanoassembly for the inhibition of tumor growth and metastasis, the lack of… Continue reading A Peptide-Conjugated Probe with Cleavage-Induced Morphological Change for Treatment on Tumor Cell Membrane
2023 / Advanced science
Photodynamic therapy (PDT) is a light triggered therapy by producing reactive oxygen species (ROS), but traditional PDT may suffer from… Continue reading A H2O2-Supplied Supramolecular Material for Post-irradiated Infected Wound Treatment
2023 / Nature Communications
Sensing small biomolecules in biofluids remains challenging for many optical chemosensors based on supramolecular host-guest interactions due to adverse interplays… Continue reading A supramolecular cucurbit[8]uril-based rotaxane chemosensor for the optical tryptophan detection in human serum and urine
