2004 / PNAS
The causative agent of a recent outbreak of an atypical pneumonia, known as severe acute respiratory syndrome (SARS), has been… Continue reading Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus
2005 / Journal of Virology
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a newly identified member of the family Coronaviridae and poses a serious public… Continue reading Identification and Characterization of the Putative Fusion Peptide of the Severe Acute Respiratory Syndrome-Associated Coronavirus Spike Protein
2008 / ChemBioChem
The helicase from severe acute respiratory syndrome coronavirus (SARS‐CoV) possesses NTPase, duplex RNA/DNA‐unwinding and RNA‐capping activities that are essential for… Continue reading Differential Inhibitory Activities and Stabilisation of DNA Aptamers against the SARS Coronavirus Helicase
2006 / Viral Research
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is the cause of an atypical pneumonia that affected Asia, North America and Europe… Continue reading Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein
2005 / Journal of Biological Chemistry
The severe acute respiratory syndrome (SARS) coronavirus (CoV) main protease represents an attractive target for the development of novel anti-SARS… Continue reading Critical Assessment of Important Regions in the Subunit Association and Catalytic Action of the Severe Acute Respiratory Syndrome Coronavirus Main Protease
2004 / Journal of Biological Chemistry
Severe acute respiratory syndrome (SARS) coronavirus is a novel human coronavirus and is responsible for SARS infection. SARS coronavirus 3C-like… Continue reading Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization
2005 / Proteomics
Severe acute respiratory syndrome (SARS) is a serious health threat and its early diagnosis is important for infection control and… Continue reading Biochemical and immunological studies of nucleocapsid proteins of severe acute respiratory syndrome and 229E human coronaviruses
2008 / The FEBS Journal
Coronavirus nucleocapsid protein is abundant in infected cells and participates in viral RNA replication and transcription. The central domain of… Continue reading Phosphorylation of the arginine/serine dipeptide‐rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization
2004 / Biochemistry
Coronavirus (CoV) entry is mediated by the viral spike (S) glycoprotein, a class I viral fusion protein. During viral and… Continue reading The Aromatic Domain of the Coronavirus Class I Viral Fusion Protein Induces Membrane Permeabilization: Putative Role during Viral Entry
2004 / Biochemistry
SARS (severe acute respiratory syndrome) has been one of the most severe viral infectious diseases last year and still remains… Continue reading Quaternary Structure of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Main Protease
2020 / ACS Synthetic Biology
Recently, we designed and assembled protein nanobuilding blocks (PN-Blocks) from an intermolecularly folded dimeric de novo protein called WA20. Using this dimeric… Continue reading Hyperstable De Novo Protein with a Dimeric Bisecting Topology
2020 / Bioconjugate Chemistry
For chemical modification of cysteines in a protein, the regioselectivity among cysteine residues on the protein surface is an issue… Continue reading Regioselective Chemical Modification of Cysteine Residues on Protein Surfaces Focusing on Local Environment around the Conjugation Site
2020 / bioRxiv
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a ligand of low-density lipoprotein receptor (LDLR) that promotes LDLR degradation in late endosomes/lysosomes.… Continue reading A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles
2020 / Bioorganic & Medicinal Chemistry
G-Quadruplex DNAs, formed by G-rich DNA sequences in human genes, are promising targets for design of cancer drugs. In this… Continue reading Synthesis, G-Quadruplex DNA binding and cytotoxic properties of naphthalimide substituted styryl dyes
2020 / Computational Toxicology
Human serum albumin (HSA) is involved in transporting a wide range of therapeutic agents. This involvement determines the pharmacokinetics and… Continue reading Kolaflavanone of kolaviron selectively binds to subdomain 1B of human serum albumin: spectroscopic and molecular docking evidences
2020 / Nucleic Acids Research
I-motif DNAs have been widely employed as robust modulating components to construct reconfigurable DNA nanodevices that function well in acidic… Continue reading I-Motif/miniduplex hybrid structures bind benzothiazole dyes with unprecedented efficiencies: a generic light-up system for label-free DNA nanoassemblies and bioimaging
2020 / molecules
The properties of non-canonical DNA structures, like G-quadruplexes and triplexes, change under cell-mimicking molecular crowding conditions relative to dilute aqueous… Continue reading Effect of Potassium Concentration on Triplex Stability under Molecular Crowding Conditions
2020 / bioRxiv
DNA is polymorphic since, despite its ubiquitous presence as a double-stranded helix, it is able to fold into a plethora… Continue reading Harnessing intrinsic fluorescence for typing of secondary structures of DNA
2020 / Nature nanotechnology
Chirality—the property of an object wherein it is distinguishable from its mirror image—is of widespread interest in chemistry and biology1,2,3,4,5,6.… Continue reading Regioselective magnetization in semiconducting nanorods
2020 / molecules
Here, we report the formation of homochiral supramolecular thin film from achiral molecules, by using circularly polarized light (CPL) only… Continue reading Homochiral Supramolecular Thin Film from Self-Assembly of Achiral Triarylamine Molecules by Circularly Polarized Light
