2020 / Nucleic Acids Research
One of the major hurdles in RNAi research has been the development of safe and effective delivery systems for siRNAs.… Continue reading Targeted delivery and enhanced gene-silencing activity of centrally modified folic acid–siRNA conjugates
2020 / Nucleic Acids Research
i-Motifs are widely used in nanotechnology, play a part in gene regulation and have been detected in human nuclei. As… Continue reading Epigenetic modification of cytosines fine tunes the stability of i-motif DNA
2020 / Marine Drugs
KTM is a 16 amino acid peptide with the sequence WCCSYPGCYWSSSKWC. Here, we present the nuclear magnetic resonance (NMR) structure… Continue reading Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors
2020 / Biophysical Journal
Nanodiscs (NDs) are an excellent alternative to small unilamellar vesicles (SUVs) for studies of membrane protein structure, but it has… Continue reading Folding of the β-Barrel Membrane Protein OmpA into Nanodiscs
2020 / Food Hydrocolloids
In the current study, the foaming properties of native egg white proteins (EWP) were compared to those of fibrillated EWP… Continue reading Physico-chemical and foaming properties of nanofibrillated egg white protein and its functionality in meringue batter
2019 / Scientific Reports
Insulin-like peptide 5 (INSL5) is a very important pharma target for treating human conditions such as anorexia and diabetes. However,… Continue reading Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4
2020 / Bioorganic Chemistry
In this study, a series of uridine (U) and 2′-deoxyuridine (dU) conjugates containing an isomeric ortho-, meta- or para-carborane cluster (C2B10H12) attached at C-5… Continue reading Comparative study of the effects of ortho-, meta- and para-carboranes (C2B10H12) on the physicochemical properties, cytotoxicity and antiviral activity of uridine and 2′-deoxyuridine boron cluster conjugates
2020 / Analytical Chemistry
Regulation of protein’s charge state in electrospray is of great importance to the analysis of proteins. Different methods have been… Continue reading Strong Acid Anions Significantly Increasing the Charge State of Proteins during Electrospray Ionization
2020 / International Journal of Biological Macromolecules
Proper interaction between the divisome proteins FtsA and FtsZ is important for the bacterial cell division which is not well… Continue reading FtsA-FtsZ interaction in Vibrio cholerae causes conformational change of FtsA resulting in inhibition of ATP hydrolysis and polymerization
2020 / Biochimica et Biophysica Acta (BBA) - General Subjects
Isomerization of aspartate to isoaspartate (isoAsp) on aging causes protein damage and malfunction. Protein-L-isoaspartyl methyltransferase (PIMT) performs a neuroprotective role… Continue reading The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase
2020 / Physical Chemistry Chemical Physics
Cells are crowded with various cosolutes including salts, osmolytes, nucleic acids, peptides and proteins. These cosolutes modulate the protein folding… Continue reading Thermal stability modulation of the native and chemically-unfolded state of bovine serum albumin by amino acids
2019 / The FEBS Journal
It is now accepted that reactive oxygen species (ROS) are not only dangerous oxidative agents but also chemical mediators of… Continue reading On the mechanism of calcium‐dependent activation of NADPH oxidase 5 (NOX5)
2019 / Journal of Agriculture and Food Chemistry
Herbicidal activity-guided isolation from the fermentation extract of Penicillium viridicatum had obtained two herbicidal series of polyketides (1–7) and diketopiperazine derivatives (8–11),… Continue reading Herbicidal Polyketides and Diketopiperazine Derivatives from Penicillium viridicatum
2019 / Journal of Molecular Liquids
Forming of neurotoxic aggregates of a small neuronal protein – alpha-synuclein (ASN) – is considered one of the main reasons of… Continue reading Inhibitory effect of Euphorbia tannins on α-synuclein aggregation in aqueous solutions
2019 / Journal of Agriculture and Food Research
Lysozyme (Ly) is a good natural food preservative. However, its enzyme activity is easily influenced by food components, such as… Continue reading Effect of tannic acid on lysozyme activity through intermolecular noncovalent binding
2019 / Drug Development Research
Monoclonal antibodies (mAbs) are currently leading products in the global biopharmaceutical market. Multiple mAbs are in clinical development and novel… Continue reading Matching pH values for antibody stabilization and crystallization suggest rationale for accelerated development of biotherapeutic drugs
2019 / Nature Communications
One of the fundamental challenges in nanophotonics is to gain full control over nanoscale optical elements. The precise spatiotemporal arrangement… Continue reading A rotary plasmonic nanoclock
2020 / Colloids and Surfaces A: Physicochemical and Engineering Aspects
The assembled behaviors of three isomeric L-glutamic lipid derivatives at the water/air interface are different via Langmuir-Blodgett method. Various nanostructures… Continue reading Interfacial assembled Langmuir films of isomeric lipid derivative: Effect of hydrogen bond and chirality transfer
2019 / Scientific Reports
Cardiolipin (CL) was shown to bound to the dimer interface of NhaA Na+/H+ antiporter. Here, we explore the cardiolipin-NhaA interaction both in… Continue reading Cardiolipin is an Optimal Phospholipid for the Assembly, Stability, and Proper Functionality of the Dimeric Form of NhaA Na+/H+ Antiporter
2019 / RSC Advances
Synthetic bioactive hydrogels have been widely recognized as key elements of emerging strategies for tissue engineering. The complex hierarchical structure… Continue reading Designing a bioactive scaffold from coassembled collagen–laminin short peptide hydrogels for controlling cell behaviour
