2023 / Scientific Reports
Excessive macrophage activation induces the release of high levels of inflammatory mediators which not only amplify chronic inflammation and degenerative …
2023 / ACS publications
Due to burgeoning interest in the pharmaceutical industry in exploiting optically active α-aminoboronic derivatives as bioisosteres of α-amino acid derivatives, …
2023 / Chirality
2-Amino[2.2]paracyclophane reacts with salicylaldehyde or 2-hydroxyacetophenone to yield imines that then give access to a new series of boranils (8b–d) …
2022 / Microbial Biotechnology
Basidiomycetes produce a wide variety of sesquiterpenoids, which attract significant interest in pharmaceutical and industrial applications. Structural diversification of sesquiterpenoids …
2022 / Fitoterapia
Two novel prenylated acetophenones with new carbon skeletons, acronyrones A and B (1 and 2), and a new analogue, acronyrone …
Continue reading “Acronyrones A–C, unusual prenylated acetophenones from Acronychia pedunculata”
2022 / Communications chemistry
A grand challenge in terpene synthase (TS) enzymology is the ability to predict function from protein sequence. Given the limited …
2022 / Nature Communications
Medermycin, produced by Streptomyces species, represents a family of antibiotics with significant activity against Gram-positive pathogens. The biosynthesis of this …
2022 / Nature Communications
Securinega alkaloids have fascinated the synthetic chemical community for over six decades. Historically, major research foci in securinega alkaloid synthesis …
2022 / Scientific Reports
The importance of plant chemistry in the host specialization of phytophagous insects has been emphasized. However, only a few chemicals …
2022 / Food Science & Nutrition
Chukrasia tabularis is an economically important tree and widely cultured in the southeast of China. Its barks, leaves, and fruits …
2022 / Scientific reports
The pandemic caused by severe acute respiratory Coronavirus-2 (SARS-CoV-2) has been ongoing for over two years, and treatment for COVID-19, …
2022 / Scientific Reports
Several strikingly different aerobic and anaerobic pathways of nicotinate breakdown are extant in bacteria. Here, through reverse genetics and analytical …
2022 / Chemistry & Biodiversity
The lichen’s special symbiotic structure enables it to produce bioactive substances. They have historically been recognized for their aesthetic and …
Continue reading “Anti-Inflammatory Potential of Compounds Isolated from Tunisian Lichens Species”
2022 / Phytotherapy Research
“Desert hyacinths” are a remarkable group of parasitic plants belonging to genus Cistanche, including more than 20 accepted species typically …
2022 / Communications Chemistry
Natural products are well established as an important resource and play an important role in drug discovery. Here, two pyrrolinone-fused …
2022 / Chirality
New racemic vicinal amino alcohol derivatives with 4-benzylidenecyclohexane skeleton and axial chirality have been prepared. A preparatively easy and efficient …
2022 / Chirality
Inositol phosphates and inositol phospholipids are ubiquitous in biochemistry and play a central role in cell signaling and regulation events. …
2022 / Nature Communications
Sarpagine-Ajmaline-Koumine type monoterpenoid indole alkaloids represent a fascinating class of natural products with polycyclic and cage-like structures, interesting biological activities, …
2022 / Nature Communications
Although computational simulation-based natural product syntheses are in their initial stages of development, this concept can potentially become an indispensable …
Continue reading “Computation-guided asymmetric total syntheses of resveratrol dimers”
2022 / Nature Communications
Axially chiral styrenes bearing a chiral axis between a sterically non-congested acyclic alkene and an aryl ring are difficult to …
Continue reading “Carbene-catalyzed atroposelective synthesis of axially chiral styrenes”
