2023 / Nature
Water is one of the most important substances on our planet1. It is ubiquitous in its solid, liquid and vaporous… Continue reading Dehydration of a Crystal Hydrate at Subglacial Temperatures
2023 / Microbial Biotechnology
R-1,3-butanediol (R-1,3-BDO) is an important chiral intermediate of penem and carbapenem synthesis. Among the different synthesis methods to obtain pure… Continue reading A Short-Chain Carbonyl Reductase Mutant Is an Efficient Catalyst in the Production of (R)-1,3-Butanediol
2023 / Scientific Reports
Tirandamycin (TAM B) is a tetramic acid antibiotic discovered to be active on a screen designed to find compounds with… Continue reading New Insights into the Neuroprotective and Beta-Secretase1 Inhibitor Profiles of Tirandamycin B Isolated from a Newly Found Streptomyces Composti Sp. Nov.
2023 / Scientific Reports
Excessive macrophage activation induces the release of high levels of inflammatory mediators which not only amplify chronic inflammation and degenerative… Continue reading In Vitro and in Silico Studies of 7′′,8′′-Buddlenol D Anti-Inflammatory Lignans from Carallia Brachiata as P38 MAP Kinase Inhibitors
2023 / ACS publications
Due to burgeoning interest in the pharmaceutical industry in exploiting optically active α-aminoboronic derivatives as bioisosteres of α-amino acid derivatives,… Continue reading Enantioselective Synthesis of α-Aminoboronic Acid Derivatives via Copper-Catalyzed N-Alkylation
2023 / Chirality
2-Amino[2.2]paracyclophane reacts with salicylaldehyde or 2-hydroxyacetophenone to yield imines that then give access to a new series of boranils (8b–d)… Continue reading Synthesis, structural characterization, and chiroptical properties of planarly and axially chiral boranils
2022 / Microbial Biotechnology
Basidiomycetes produce a wide variety of sesquiterpenoids, which attract significant interest in pharmaceutical and industrial applications. Structural diversification of sesquiterpenoids… Continue reading Biocatalyst collection and heterologous expression of sesquiterpene synthases from basidiomycetous fungi: Discovery of a novel sesquiterpene hydrocarbon
2022 / Fitoterapia
Two novel prenylated acetophenones with new carbon skeletons, acronyrones A and B (1 and 2), and a new analogue, acronyrone… Continue reading Acronyrones A–C, unusual prenylated acetophenones from Acronychia pedunculata
2022 / Communications chemistry
A grand challenge in terpene synthase (TS) enzymology is the ability to predict function from protein sequence. Given the limited… Continue reading Structure-guided product determination of the bacterial type II diterpene synthase Tpn2
2022 / Nature Communications
Securinega alkaloids have fascinated the synthetic chemical community for over six decades. Historically, major research foci in securinega alkaloid synthesis… Continue reading Collective total synthesis of C4-oxygenated securinine-type alkaloids via stereocontrolled diversifications on the piperidine core
2022 / Nature Communications
Medermycin, produced by Streptomyces species, represents a family of antibiotics with significant activity against Gram-positive pathogens. The biosynthesis of this… Continue reading Chimeric natural products derived from medermycin and the nature-inspired construction of their polycyclic skeletons
2022 / Scientific Reports
The importance of plant chemistry in the host specialization of phytophagous insects has been emphasized. However, only a few chemicals… Continue reading Oviposition stimulants underlying different preferences between host races in the leaf-mining moth Acrocercops transecta (Lepidoptera: Gracillariidae)
2022 / Food Science & Nutrition
Chukrasia tabularis is an economically important tree and widely cultured in the southeast of China. Its barks, leaves, and fruits… Continue reading Bioactivity-guided isolation of anti-inflammatory limonins from Chukrasia tabularis
2022 / Scientific reports
The pandemic caused by severe acute respiratory Coronavirus-2 (SARS-CoV-2) has been ongoing for over two years, and treatment for COVID-19,… Continue reading (+)-Usnic acid and its salts, inhibitors of SARS‐CoV‐2, identified by using in silico methods and in vitro assay
2022 / Scientific Reports
Several strikingly different aerobic and anaerobic pathways of nicotinate breakdown are extant in bacteria. Here, through reverse genetics and analytical… Continue reading A complete nicotinate degradation pathway in the microbial eukaryote Aspergillus nidulans
2022 / Phytotherapy Research
“Desert hyacinths” are a remarkable group of parasitic plants belonging to genus Cistanche, including more than 20 accepted species typically… Continue reading In vitro characterization of iridoid and phenylethanoid glycosides from Cistanche phelypaea for nutraceutical and pharmacological applications
2022 / Chemistry & Biodiversity
The lichen’s special symbiotic structure enables it to produce bioactive substances. They have historically been recognized for their aesthetic and… Continue reading Anti-Inflammatory Potential of Compounds Isolated from Tunisian Lichens Species
2022 / Communications Chemistry
Natural products are well established as an important resource and play an important role in drug discovery. Here, two pyrrolinone-fused… Continue reading Discovery, total syntheses and potent anti-inflammatory activity of pyrrolinone-fused benzoazepine alkaloids Asperazepanones A and B from Aspergillus candidus
2022 / Chirality
New racemic vicinal amino alcohol derivatives with 4-benzylidenecyclohexane skeleton and axial chirality have been prepared. A preparatively easy and efficient… Continue reading Synthesis, resolution, and absolute configuration determination of a vicinal amino alcohol with axial chirality. Application to the synthesis of new box and pybox ligands
2022 / Chirality
Inositol phosphates and inositol phospholipids are ubiquitous in biochemistry and play a central role in cell signaling and regulation events.… Continue reading 2-O-Acetyl-3,4,5,6-tetra-O-benzyl-d-myo-inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids
