New Insights into the Neuroprotective and Beta-Secretase1 Inhibitor Profiles of Tirandamycin B Isolated from a Newly Found Streptomyces Composti Sp. Nov.

2023 / Scientific Reports

Tirandamycin (TAM B) is a tetramic acid antibiotic discovered to be active on a screen designed to find compounds with… Continue reading New Insights into the Neuroprotective and Beta-Secretase1 Inhibitor Profiles of Tirandamycin B Isolated from a Newly Found Streptomyces Composti Sp. Nov.

Carlos Morillo

In Vitro and in Silico Studies of 7′′,8′′-Buddlenol D Anti-Inflammatory Lignans from Carallia Brachiata as P38 MAP Kinase Inhibitors

2023 / Scientific Reports

Excessive macrophage activation induces the release of high levels of inflammatory mediators which not only amplify chronic inflammation and degenerative… Continue reading In Vitro and in Silico Studies of 7′′,8′′-Buddlenol D Anti-Inflammatory Lignans from Carallia Brachiata as P38 MAP Kinase Inhibitors

Carlos Morillo

Biocatalyst collection and heterologous expression of sesquiterpene synthases from basidiomycetous fungi: Discovery of a novel sesquiterpene hydrocarbon

2022 / Microbial Biotechnology

Basidiomycetes produce a wide variety of sesquiterpenoids, which attract significant interest in pharmaceutical and industrial applications. Structural diversification of sesquiterpenoids… Continue reading Biocatalyst collection and heterologous expression of sesquiterpene synthases from basidiomycetous fungi: Discovery of a novel sesquiterpene hydrocarbon

Carlos Morillo

Collective total synthesis of C4-oxygenated securinine-type alkaloids via stereocontrolled diversifications on the piperidine core

2022 / Nature Communications

Securinega alkaloids have fascinated the synthetic chemical community for over six decades. Historically, major research foci in securinega alkaloid synthesis… Continue reading Collective total synthesis of C4-oxygenated securinine-type alkaloids via stereocontrolled diversifications on the piperidine core

Carlos Morillo

Oviposition stimulants underlying different preferences between host races in the leaf-mining moth Acrocercops transecta (Lepidoptera: Gracillariidae)

2022 / Scientific Reports

The importance of plant chemistry in the host specialization of phytophagous insects has been emphasized. However, only a few chemicals… Continue reading Oviposition stimulants underlying different preferences between host races in the leaf-mining moth Acrocercops transecta (Lepidoptera: Gracillariidae)

Carlos Morillo

In vitro characterization of iridoid and phenylethanoid glycosides from Cistanche phelypaea for nutraceutical and pharmacological applications

2022 / Phytotherapy Research

“Desert hyacinths” are a remarkable group of parasitic plants belonging to genus Cistanche, including more than 20 accepted species typically… Continue reading In vitro characterization of iridoid and phenylethanoid glycosides from Cistanche phelypaea for nutraceutical and pharmacological applications

Carlos Morillo

Discovery, total syntheses and potent anti-inflammatory activity of pyrrolinone-fused benzoazepine alkaloids Asperazepanones A and B from Aspergillus candidus

2022 / Communications Chemistry

Natural products are well established as an important resource and play an important role in drug discovery. Here, two pyrrolinone-fused… Continue reading Discovery, total syntheses and potent anti-inflammatory activity of pyrrolinone-fused benzoazepine alkaloids Asperazepanones A and B from Aspergillus candidus

Carlos Morillo

Synthesis, resolution, and absolute configuration determination of a vicinal amino alcohol with axial chirality. Application to the synthesis of new box and pybox ligands

2022 / Chirality

New racemic vicinal amino alcohol derivatives with 4-benzylidenecyclohexane skeleton and axial chirality have been prepared. A preparatively easy and efficient… Continue reading Synthesis, resolution, and absolute configuration determination of a vicinal amino alcohol with axial chirality. Application to the synthesis of new box and pybox ligands

Carlos Morillo