2022 / Nature Communications
Sarpagine-Ajmaline-Koumine type monoterpenoid indole alkaloids represent a fascinating class of natural products with polycyclic and cage-like structures, interesting biological activities,… Continue reading Structure units oriented approach towards collective synthesis of sarpagine-ajmaline-koumine type alkaloids
2022 / Nature Communications
Axially chiral styrenes bearing a chiral axis between a sterically non-congested acyclic alkene and an aryl ring are difficult to… Continue reading Carbene-catalyzed atroposelective synthesis of axially chiral styrenes
2022 / Nature Communications
Although computational simulation-based natural product syntheses are in their initial stages of development, this concept can potentially become an indispensable… Continue reading Computation-guided asymmetric total syntheses of resveratrol dimers
2021 / Chemistry A European Journal
TAMOF-1, a homochiral metal-organic framework (MOF) constructed from an amino acid derivative and Cu(II), was investigated as a heterogeneous catalyst… Continue reading Differentiation of Epoxide Enantiomers in the Confined Spaces of an Homochiral Cu(II) Metal-Organic Framework by Kinetic Resolution
2021 / ChemMedChem
The generation of peptidomimetic substructures for medicinal chemistry purposes requires effective and divergent synthetic methods. We present in this work… Continue reading Coupling Interrupted Fischer and Multicomponent Joullié-Ugi to Chase Chemical Diversity: from Batch to Sustainable Flow Synthesis of Peptidomimetics
2021 / Chirality
(1R,5S)-2-Methyl-6,7-benzomorphan has been synthesised from (R)-(benzyloxy)(phenyl)acetaldehyde. On a 2-mmol scale Bi (OTf)3 promoted Aza-Prins reaction with N-tosylhomoallylamine afforded an 88/12… Continue reading Asymmetric synthesis of (1R,5S)-2-methyl-6,7-benzomorphan via Aza-Prins reaction
2021 / Chemistry A European Journal
A stereogenic π-system based on dimer (2) and trimer (3) of [2.2]paracyclophane (PC) and biphenyl was prepared and its structural,… Continue reading Helical Oligophenylene Linked with [2.2]Paracyclophane: Stereogenic π-Conjugated Dye for Highly Emissive Chiroptical Properties
2021 / biomolecules
The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral RNA and is highly conserved… Continue reading Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins
2021 / biomolecules
The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral RNA and is highly conserved… Continue reading Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins
2021 / Natural Product Research
(+)- and (−)-Spongiterpene [(+)-1 and (−)-1], a pair of new valerenane sesquiterpene enantiomers, along with four known compounds (2-5) were… Continue reading (+)- and (−)-Spongiterpene, a pair of new valerenane sesquiterpene enantiomers from the marine sponge Spongia Sp.
2021 / Royal Society of Chemistry
Hyperacmosins K–M (1–3), three new polycyclic polyprenylated acylphloroglucinol (PPAPs) derivatives, were isolated from the air-dried aerial parts of Hypericum asmosepalum.… Continue reading Hyperacmosins K–M, three new polycyclic polyprenylated acylphloroglucinols from Hypericum acmosepalum
2021 / pharmaceuticals
A novel cyclic antimalarial and antitrypanosome hexapeptide, pipecolisporin (1), was isolated from cultures of Nigrospora oryzae CF-298113, a fungal endophyte… Continue reading Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae
2021 / Natural Product Research
Three new sesquiterpene lactones, named scabertopinolides H − J (1 − 3), along with four known ones, desacylisodeoxyelephantopin 2-methylbutyrate (4), iso-17,19-dihydrodeoxyelephantopin (5), scabertopinolide D… Continue reading Three new sesquiterpene lactones from the whole plants of Elephantopus scaber
2021 / Journal of Asian Natural Products Research
Phytochemical investigation on the 80% EtOH extract of the whole plants of Zephyranthes grandiflora afforded three new 4a-epi-plicamine-type alkaloids, zephyranthines… Continue reading Cytotoxic plicamine alkaloids from the whole plants of Zephyranthes grandiflora
2021 / Bioorganic Chemistry
Nine undescribed monoterpene phenol dimers, bisbakuchiols D-L (1–9), were isolated from the fruits of Psoralea corylifolia L. Their structures were… Continue reading Bioactive monoterpene phenol dimers from the fruits of Psoralea corylifolia L.
2021 / Bioorganic Chemistry
Bioassay-guided fractionation led to the isolation of a series of triterpenoids (1–46) including 12 new ones (1–12) from the mushroom… Continue reading Inhibitory effect of triterpenoids from the mushroom Inonotus obliquus against α-glucosidase and their interaction: Inhibition kinetics and molecular stimulations
2021 / frontiers in Microbiology
The fungal strains Pseudogymnoascus are a kind of psychrophilic pathogenic fungi that are ubiquitously distributed in Antarctica, while the studies… Continue reading Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11
2021 / Fitoterapia
Vernoramyosides A-F (1–6), six new Δ7,9(11) stigmastane-type steroid saponins, along with four known analogues (7–10) were isolated from the leaves… Continue reading Stigmastane-type steroid saponins from the leaves of Vernonia amygdalina Del
2021 / Journal of Asian Natural Products Research
A new aurone glycoside named licoagroaurone 6-O-α-ʟ-arabinopyranoside (1), together with six known compounds (2–7), was isolated from EtOAc-soluble extract of… Continue reading Chemical constituents from the aerial parts of Saussurea involucrata with their inhibitory activities on α-glucosidase
2021 / Natural Product Research
Cladosporine A (1), a new indole diterpenoid alkaloid, was isolated from the extract of a fungal strain Cladosporium sp. JNU17DTH12-9-01.… Continue reading Cladosporine A, a new indole diterpenoid alkaloid with antimicrobial activities from Cladosporium sp.
