2021 / Phytochemistry Letters
Five new galloyl glucosides of 2-C-methyl-D-erythriol (1–4) and homogentisic acid (5) were isolated from the aerial parts of Saxifraga spinulosa.… Continue reading Anti-piroplasma activity of 2-methylbutane galloyl glycosides from Saxifraga spinulosa
2021 / Bioorganic Chemistry
Neuroinflammation is emerging as a crucial reason of major neurodegenerative diseases in recent years. Increasingly evidences have supported that bioactive… Continue reading Neuroprotective and anti-inflammatory phenylethanoid glycosides from the fruits of Forsythia suspensa
2021 / Fitoterpia
Four new alkaloids, nonialkaloids A–D (1–4) and six known analogues (5–10) were isolated from the noni juice. Among the new… Continue reading New alkaloids from the noni juice with potential α-glucosidase inhibitory activity
2021 / Fitoterpia
Phytochemical study on a non-medicinal part of a plant material for herbal medicine, the roots of Schisandra chinensis, was conducted… Continue reading Studies on non-medicinal parts of plant materials: Triterpenes from the roots of Schisandra chinensis
2021 / Archives of Pharmacal Research
Ginkgo biloba (Ginkgoaceae), commonly known as “ginkgo”, is called a living fossil, and it has been cultivated early in human… Continue reading Ginkwanghols A and B, osteogenic coumaric acid-aliphatic alcohol hybrids from the leaves of Ginkgo biloba
2021 / Amino Acids
Nα-2-thiophenoyl-d-phenylalanine-2-morpholinoanilide (MMV688845, IUPAC: N-(1-((2-morpholinophenyl)amino)-1-oxo-3-phenylpropan-2-yl)thiophene-2-carboxamide) from the Pathogen Box® library (Medicines for Malaria Ventures, MMV) is a promising lead compound for… Continue reading Racemization-free synthesis of Nα-2-thiophenoyl-phenylalanine-2-morpholinoanilide enantiomers and their antimycobacterial activity
2021 / Fitoterpia
A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition,… Continue reading Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line
2021 / Planta
Sorghum (Kaoliang) grain is an important crop with high economic value and several applications. In Taiwan, sorghum has been used… Continue reading Bioactive polyketides from the pathogenic fungus of Epicoccum sorghinum
2021 / Fitoterapia
The first phytochemical investigation from the stems of Croton krabas resulted in the isolation of three new ent-clerodane diterpenoids, crotonkrabases… Continue reading ent-Clerodane diterpenoids from the stems of Croton krabas
2021 / Fitoterapia
Two new daphnane-type diterpenoids fischerianin A (1) and fischerianin B (2), as well as two known ones langduin A (3)… Continue reading Daphnane-type diterpenoids from Euphorbia fischeriana Steud and their cytotoxic activities
2021 / Bioorganic chemistry
Two new tetrahydrobenzannulated 5,5-spiroketal sesquiterpenes (1 and 2) and three novel benzannulated 5,5-spiroketal sesquiterpenes (3–5) namely angepubesins A-E, together with… Continue reading Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica Pubescens
2021 / Phytochemistry Letters
Three new flavonoids, including a new prenylated aurone, 7,2′,5′-trihydroxy-8-prenylaurone (1), and two new flavanones, 2(S)-4′-hydroxy-6-methoxy-7-(2”-hydroxy-3”-methybult-3”-enyl)flavanone (2) and 2(S)-4′-hydroxy-7-methoxy-6-(1”,2”-epoxy-3”-hydroxy-dimethyl)flavanone (3), together… Continue reading Flavonoids from the seeds of Psoralea corylifolia inhibit diacylglycerol acyltransferase
2021 / Fitoterapia
Four previously unreported sesquiterpenoid diasteromers, arteannoides U–X (1–4), together with one new norsesquiterpenoid 5 (arteannoide Y) and one undescribed rearranged… Continue reading Arteannoides U–Z: Six undescribed sesquiterpenoids with anti-inflammatory activities from the aerial parts of Artemisia annua (Qinghao)
2021 / Fitoterapia
Eight new stilbene dimer xylosides (1–8) and one new flavanol (9), along with seven known ones (10–16) were isolated from… Continue reading Stilbene dimer xylosides and flavanols from the roots of Lysidice rhodostegia and their antioxidant activities
2021 / Biomolecules
Natural products have been fundamental materials in drug discovery. Traditional strategies for observing natural products with novel structure and/or biological… Continue reading Dilignans with a Chromanol Motif Discovered by Molecular Networking from the Stem Barks of Magnolia obovata and Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activity
2021 / Scientific Report
Wild ginseng (Panax ginseng) adventitious root cultures were prepared by elicitation using methyl jasmonate and investigated further to find new… Continue reading Curcubinoyl flavonoids from wild ginseng adventitious root cultures
2021 / Fitoterapia
Phytochemical investigation on the aerial parts of a Lamiaceous medicinal plant Perovskia scrophulariifolia collected in Uzbekistan resulted in the isolation… Continue reading Diterpenes from an Uzbek medicinal plant Perovskia scrophulariifolia: Their structures and anti-neuroinflammatory activity
2021 / Photochemistry Letters
Chaperones Tapasin and TAP-binding protein related (TAPBPR) perform the important functions of stabilizing nascent MHC-I molecules (chaperoning) and selecting high-affinity… Continue reading New compounds from the aerial parts of Calligonum mongolicum
2021 / Nature Communications
Stereoselective halogenation is a highly useful organic transformation for multistep syntheses because the resulting chiral organohalides can serve as precursors… Continue reading Enantioselective decarboxylative chlorination of β-ketocarboxylic acids
2021 / Scientific Report
Two-pore channel 2 (TPC2) resides in endolysosomal membranes but also in lysosome-related organelles such as the melanin producing melanosomes. Gain-of-function… Continue reading Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2
